Neonatal Respiratory Health Research

Inflammatory blockade prevents injury to the developing pulmonary gas exchange surface in preterm primates

This study shows that blocking inflammation in preterm primates prevents lung injury, preserving alveolar structure and function similar to chronic lung disease in newborns.

Characterization of alveolar epithelial lineage heterogeneity during the late pseudoglandular stage of mouse lung development

This study investigates Fgfr2b signaling's role in alveolar epithelial lineage commitment during mouse lung development and injury repair, identifying key regulatory genes and lineage contributions.

Embigin deficiency leads to delayed embryonic lung development and high neonatal mortality

The paper shows that Embigin deficiency causes delayed embryonic lung development and high neonatal mortality in mice.

Acquisition of alveolar fate and differentiation competence by human fetal lung epithelial progenitor cells

This study identifies a human fetal lung progenitor cell population with alveolar fate potential and develops an organoid system to study alveolar development mechanisms.

Lung mesenchymal cell diversity rapidly increases at birth and is profoundly altered by hyperoxia

The paper uses single-cell transcriptomics and in-situ imaging to study lung mesenchymal cell diversity during development and hyperoxia, finding delayed diversity and emergence of Acta1+ cells under hyperoxic conditions.

Developmental diversity and unique sensitivity to injury of lung endothelial subtypes during a period of rapid postnatal growth

The paper profiles the transcriptional development and injury sensitivity of lung endothelial subtypes during postnatal growth, revealing distinct transcriptomic changes and differential responses to hyperoxia.

Characterization in mice of the stromal niche maintaining AT2 stem cell self-renewal in homeostasis and disease

This study identifies rMC-Sca1PosFgf10Pos cells as a functional population critical for maintaining AT2 stem cell self-renewal and differentiation in mice, with implications for fibrosis and COVID-19 pathogenesis.

Lymphocyte-Specific Biomarkers Associated with Preterm Birth and Bronchopulmonary Dysplasia

The paper identifies gene expression patterns in CD8+ T cells associated with BPD and PRD in preterm infants using transcriptomic data from the PROP cohort.

The involvement of HDAC3-mediated inhibition of microRNA cluster 17-92 in hyperoxia-mediated impairment of lung development in neonatal rats

This study investigates how HDAC3 regulates alveolarization and angiogenesis in BPD by modulating the miR-17-92 cluster and the EZH1-p65-Pgf axis.

3D cell culture models demonstrate a role for FGF and WNT signaling in regulation of lung epithelial cell fate and morphogenesis

This study uses 3D cell culture models to investigate the role of FGF and WNT signaling in lung epithelial cell fate and morphogenesis, revealing their effects on organoid formation and differentiation.

Developmental Expression of Transforming Growth Factor Induced Protein Promotes NF-Kappa-B Mediated Angiogenesis During Postnatal Lung Development

The paper identifies TGFBI as a protein promoting NF-kappa-B mediated angiogenesis during early lung development by enhancing nitric oxide production.

A smooth muscle-like niche facilitates lung epithelial regeneration

This study identifies a repair-supportive mesenchymal cell population critical for lung epithelial regeneration through single-cell RNA sequencing and lineage tracing.

Myh10 deficiency leads to defective extracellular matrix remodeling and pulmonary disease

This study identifies Myh10 as critical for alveolar development and ECM remodeling, linking its deficiency to pulmonary disease and emphysema.

Ancestry and Genetic Associations with Bronchopulmonary Dysplasia in Preterm Infants

This study identifies genetic variants and pathways associated with reduced risk of bronchopulmonary dysplasia in preterm infants, highlighting racial/ethnic differences in response to nitric oxide treatment.

On growth and form of the distal air exchange surfaces within the lung.

The paper uses novel imaging and computational approaches to deduce how distal air exchange surfaces in the lung form through epithelial buckling and extrusion, stabilized by elastin and collagen rings.