Neonatal Respiratory Health Research

Characterization of hyperoxia-induced senescent lung macrophages in neonatal mice

The paper characterizes hyperoxia-induced senescent lung macrophages in neonatal mice using scRNA-seq data, identifying distinct clusters with specific gene expression and metabolic features.

The identification and characterization of hillocks in the postnatal mouse and human airway

The paper identifies and characterizes hillocks in postnatal mouse and human airways, showing their presence from postnatal day 3 and functional maturation during development.

The homeobox transcription factor Cux1 coordinates postnatal epithelial developmental timing but is dispensable for lung organogenesis and regeneration

The paper investigates the role of Cux1 in postnatal epithelial development, finding that its loss causes transient developmental delays in multiple tissues without affecting organogenesis or regeneration.

Amniotic fluid stem cell extracellular vesicles promote lung development via TGF-beta modulation in a fetal rat model of oligohydramnios

This study shows that amniotic fluid stem cell extracellular vesicles improve lung development in a fetal rat model of oligohydramnios by modulating TGF-beta signaling through miR-93-5p.

PRDM3/16 Regulate Chromatin Accessibility Required for NKX2-1 Mediated Alveolar Epithelial Differentiation and Function

This study shows PRDM3 and PRDM16 regulate chromatin accessibility to support NKX2-1-driven alveolar epithelial differentiation and function, with loss leading to respiratory failure and lineage infidelity.

Bronchopulmonary Dysplasia with Pulmonary Hypertension Associates with Loss of Semaphorin Signaling and Functional Decrease in FOXF1 Expression

The paper identifies loss of semaphorin signaling and reduced FOXF1 expression in BPD and BPD+PH using single-cell RNA sequencing and validates findings in a murine model.

Inhibition of CELA1 Improves Septation in the Mouse Hyperoxia Model of Impaired Alveolar Development

Defective mesenchymal Bmpr1a-mediated BMP signaling causes congenital pulmonary cysts

This study identifies defective mesenchymal Bmpr1a-mediated BMP signaling as a cause of congenital pulmonary cysts by disrupting lung branching morphogenesis and airway structure.

CEBPA restricts alveolar type 2 cell plasticity during development and injury-repair

This study shows that CEBPA restricts alveolar type 2 cell plasticity in mice, with loss of CEBPA allowing reactivation of a progenitor program in neonatal cells and increased plasticity in mature cells after injury.

Endothelial deletion of p53 generates transitional endothelial cells and improves lung development during neonatal hyperoxia

The paper shows that deleting p53 in endothelial cells during hyperoxia generates transitional endothelial cells, improving lung development and reversing vascular damage in BPD.

Identification of a myofibroblast differentiation program during neonatal lung development

The paper identifies a myofibroblast differentiation program during neonatal lung development using single-cell RNA sequencing and lineage tracing in mice.

Macrophage Polarizations in the Placenta and Lung are Associated with Bronchopulmonary Dysplasia

This study investigates the relationship between placental and lung macrophage polarization and their role in the development of bronchopulmonary dysplasia.

Modulation of Recovery from Neonatal Hyperoxic Lung Injury by Sex as a Biological Variable

This study uses scRNA-seq to analyze sex-based differences in neonatal lung injury recovery in mice, identifying transcriptional changes and cell-cell communication patterns influenced by biological sex.

Opposing roles for TGFbeta and BMP-signaling during nascent alveolar differentiation in the developing human lung

This study identifies opposing roles for TGFbeta and BMP signaling in generating AT2-like cells from lung progenitors in vitro.

Epigenetic Regulation of Endothelial Extracellular Matrix Components is Critical for Murine Lung Development

This study shows that BRG1 and CHD4 regulate endothelial extracellular matrix components through epigenetic mechanisms, essential for proper lung development in mice.

Mitochondrial DNA Variations Modulate Alveolar Epithelial Mitochondrial Function and Oxidative Stress in Newborn Mice Exposed to Hyperoxia

This study shows that mtDNA variations affect mitochondrial function and oxidative stress in newborn mice exposed to hyperoxia, with implications for BPD risk in human infants.

Respiratory strategy at birth initiates distinct lung injury phenotypes in the preterm lamb lung

This study uses mass spectrometry to identify protein-based lung injury phenotypes in preterm lambs based on different ventilation strategies and their associated molecular and physiological outcomes.

ΔNp63 drives dysplastic alveolar remodeling and restricts epithelial plasticity upon severe lung injury

This study identifies ΔNp63 as a driver of dysplastic alveolar remodeling by restricting fate plasticity of p63+ progenitors in severe lung injury.

Alveolar cell fate selection and lifelong maintenance of AT2 cells by FGF signaling

This study identifies FGF signaling as critical for specifying and maintaining alveolar type 2 (AT2) cells, with implications for lung disease and cancer.

Remarkable Sex-Specific Differences at Single-Cell Resolution in Neonatal Hyperoxic Lung Injury

The paper investigates sex-specific and cell-type specific transcriptional changes in neonatal hyperoxic lung injury using single-cell RNA sequencing in mice.

Decoding the IGF1 Signaling Gene Regulatory Network Behind Alveologenesis from A Mouse Model of Bronchopulmonary Dysplasia

The paper constructs a gene regulatory network (GRN) for alveologenesis in a mouse model of BPD, revealing how IGF1 signaling regulates lung development and identifies potential therapeutic targets.

Epithelial Outgrowth Through Mesenchymal Rings Drives Alveologenesis

The paper observes alveoli formation through epithelial outgrowth and mesenchymal rings in live lung slices, challenging the existing model of airspace subdivision.

RTK signalling promotes epithelial columnar cell shape and apical junction maintenance in human lung progenitor cells

Alveolar epithelial progenitor cells drive lung regeneration via dynamic changes in chromatin topology modulated by lineage-specific Nkx2-1 activity

This study identifies Nkx2-1-driven chromatin topology changes in alveolar epithelial progenitor cells that regulate lung regeneration and differentiation.

Fetal maturation revealed by amniotic fluid cell-free transcriptome in rhesus macaques

The paper uses transcriptomic data from amniotic fluid and fetal tissues to identify biomarkers of fetal maturity in rhesus macaques, showing that cell-free RNA can predict lung compliance and gestational age.

Neonatal hyperoxia induces sex-dependent pulmonary cellular and transcriptomic changes in an experimental mouse model of bronchopulmonary dysplasia

This study investigates sex-dependent molecular and cellular changes in mouse lungs exposed to hyperoxia, identifying distinct progenitor and reparative responses in males and females.

R-SPONDIN2+ Mesenchymal Cells Form the Bud Tip Progenitor Niche During Human Lung Development

The paper identifies R-SPONDIN2-expressing mesenchymal cells as a niche for lung bud tip progenitors using single-cell RNA sequencing and functional experiments.

Matrix fibroblast function during alveolarization is dependent on GATA6

This study shows that GATA6 is essential for matrix fibroblast function during alveolarization, as its loss impairs alveolarization and disrupts AT1 cell differentiation.

Fgfr2b signaling is essential for the maintenance of the alveolar epithelial type 2 lineage during lung homeostasis in mice

This study shows Fgfr2b signaling is essential for maintaining AT2 cells in adult mouse lungs, with IAAPs acting as potential progenitors.

CLASP1 is essential for neonatal lung function and survival in mice

This study shows that CLASP1 is critical for neonatal lung function and survival in mice by regulating microtubule dynamics and lung development.