Neurogenesis and neuroplasticity mechanisms

This study shows that inhibiting or deleting calpain-2 increases MEIS2 levels and promotes neurogenesis in adult mice by enhancing dendritic spine maturation.

The paper characterizes the HNSC.100 neural stem cell line, showing its ability to differentiate into major neural cell types and providing gene expression data and markers for neurobiological research.

This study shows that S1PR1 regulates astrocyte morphogenesis and tiling in the developing murine cortex through competition and JAK-STAT3 signaling.

This study shows that glial cell adhesion molecules regulate neural stem cell proliferation by modulating mechanical forces and nuclear integrity in Drosophila.

This study investigates the role of Togaram1 in mammalian forebrain development using a mouse knockout, finding it crucial for forebrain size, morphology, and NSC primary cilia function.

This study shows that Tbx1 heterozygosity in the oligodendrocyte lineage causes a shift in myelinated axon composition in the mouse fimbria but not behavioral impairments.

The paper identifies intercellular signaling pathways post-ischemic stroke that regulate neural stem cell proliferation using spatial transcriptomics and computational analysis.

The paper identifies JUNB as a gene driving species-specific cortical features by comparing gene expression in mouse, human, and human cortical organoids.

The paper shows that ependymal cell cilia beating regulates neural stem cell quiescence through mechanical forces involving PKD1/2 and TRPM3.

This study shows adult-neurogenesis supports both stable and flexible odor representations in the olfactory system through experience-dependent mechanisms in different brain regions.

The paper investigates BLTP1's role in neocortical lamination by analyzing patients and mouse models, finding lipid transport defects cause structural brain abnormalities.

This study shows that temporal interference stimulation enhances neural progenitor cell maturation in vitro and promotes hippocampal neurogenesis in a mouse Alzheimer's model.

The paper identifies unique transcriptional profiles of immature neurons in aged human hippocampus across healthy, Alzheimer's disease, and resilient conditions, linking them to homeostasis and cognitive resilience.

The paper shows quiescent neural stem cells temporarily express neuronal genes to coordinate reactivation during CNS development.

This study investigates the evolutionary origins of Cajal-Retzius cells across vertebrates, finding they are conserved but gained specific transcriptomic features in amniotes.

This study identifies the role of the Asp protein in symmetrically dividing neural precursors, showing its necessity for brain growth and development in a fly model of microcephaly.

This study shows let-7 microRNA regulates both neuronal fate and migration in the neocortex through distinct pathways involving RBX2 and CRL5.

The paper quantifies neuronal birth and loss in the rat dentate gyrus across adulthood, finding that neurogenesis contributes to growth but is offset by neuronal turnover.

The paper uses connectomics to show that migrating neurons in the adult zebra finch striatum physically reshape mature circuits by creating tunnels through synapse-rich regions.

This study shows that Scd1 is required for oligodendrocyte development and myelination but not for maintaining mature myelin.

The paper shows that iPaD treatment and Prkag2 knockdown enhance neurogenesis and reduce amyloid-β in Alzheimer's disease model mice by activating AMP kinase signaling.

The paper identifies two neurogenic pathways, dNG-ETd and iNG-ETi, that differentially shape the organization and diversification of cortical output channels in mice.

The paper compiles a large transcriptomic dataset of neocortical development and uses joint matrix decomposition to identify conserved transcriptome dynamics across mammals and developmental stages.

The paper shows human-specific enhancer HAR1984 promotes neurogenesis by altering chromatin interactions and gene regulation in cortical organoids and mice.

This study shows that SOX2 phosphorylation and the PRKDC-dependent NHEJ pathway are essential for in vivo glia-to-neuron reprogramming, with p53 knockdown restoring reprogramming in PRKDC-deficient mice.

The paper measures Notch3 signaling in zebrafish adult neural stem cells and shows it correlates with quiescence and stemness, with jagged1b promoting stemness through lateral induction.

This study shows that constitutive β-Catenin activation in cortical hem progenitors disrupts CR cell identity by preventing the Tbr2+ stage.

This study shows that mTOR hyperactivity in STRADA-deficient brain organoids causes delayed neurogenesis and altered interneuron fate, which can be rescued by rapamycin.

This study shows MTCL2 links the Golgi to microtubules in cerebellar granule neurons, enabling the bipolar-to-multipolar transition of dendrite extension.