Neurogenesis and neuroplasticity mechanisms

This study identifies temporally divergent regulatory mechanisms in neuronal development and maturation across mouse and marmoset neocortex.

The paper investigates how different neuron types in the mouse visual cortex adapt myelination in response to sensory experience, finding that only inhibitory interneurons undergo experience-dependent myelin remodeling.

The paper characterizes molecular markers during in vitro adult neurogenesis in Alzheimer's disease by analyzing gene expression changes in neural progenitor cells exposed to Aβ1-42.

The paper shows that Arhgap11a mRNA localization and local translation in radial glial cells control cortical development by regulating RGC morphology and neuron positioning.

This study shows that IUGR in mice leads to accelerated DG neurogenesis and NSPC depletion, associated with memory deficits and reduced Wnt pathway activity.

This study identifies miR6236 as a microRNA suppressed by anisotropic nanodiamond surfaces that regulates neuronal development and regeneration.

This study shows that PAK3 kinase activity regulates the switch from tangential to radial migration in cortical interneurons by affecting cell shape and polarity.

This study identifies miR-19b's role in regulating proliferation and neuronal specification in the avian forebrain, highlighting similarities with mammalian neocortex development.

This study identifies CROCCP2 as a human-specific gene that enhances cortical progenitor expansion by modulating cilia dynamics and mTOR signalling.

This study investigates the effect of choline alphoscerate on cognitive function and neurogenesis in rats subjected to dual stress, finding improved memory and increased neuroblast expression in treated animals.

This study investigates how increased adult hippocampal neurogenesis affects stress-related behavior and brain network connectivity in mice exposed to chronic stress.

This study shows that Cyfip1 haploinsufficiency disrupts hippocampal neurogenesis by affecting microglial apoptosis and actin dynamics in adult-born neurons.

The paper shows that doublecortin (DCX) expression does not linearly correlate with adult hippocampal neurogenesis (AHN) in various models, highlighting the need for caution in using DCX as a proxy for AHN.

The paper estimates cell density of neurogenesis-modulating secretory cell types in the dorsal dentate gyrus of adult mice using stereological methods and immunohistochemical markers.

This study shows that OPC proliferation is required for differentiation during CNS remyelination, revealing a link between proliferation and differentiation in OPCs.

The paper identifies CSF-delivered Semaphorin complexes that regulate apical progenitor dynamics in the developing neocortex through distinct signaling pathways.

The paper identifies Pou3f1 as a marker for a previously unrecognized subtype of glutamatergic cerebellar nuclear neurons that follow a distinct transcriptional program compared to the canonical Atoh1-Pax6-Tbr1 pathway.

This study shows that MET receptor tyrosine kinase is essential for the development of laryngeal motor neurons and their function in ultrasonic vocalization in mice.

This study compares the role of adolescent- and adult-born dentate granule neurons in spatial learning and finds that their ontogenetic stage determines their involvement in memory processes.

This study shows that primary cilia regulate direct versus indirect neurogenesis in the developing cerebral cortex, with Inpp5e mutations causing increased direct neurogenesis and layer V neuron overproduction.

The paper develops genetic tools to dissect glutamatergic neuron subpopulations and their developmental trajectories in the cerebral cortex.

The paper shows that aggregated spatio-temporal division patterns in zebrafish neural stem cells arise from re-dividing cells, not random activity or population feedback.

This study identifies miR-132 deficiency as a cause of impaired adult hippocampal neurogenesis in Alzheimer's disease and shows that restoring miR-132 levels can reverse these deficits and memory issues.

This study shows that the insulin receptor is essential for maintaining adult neural stem cells and inhibiting glioblastoma stem cell self-renewal.

This study shows that human endothelial cells enhance proliferation and astrocytic differentiation of PDGFR-positive glial progenitor cells in co-culture.

This study shows that DHA enhances stem cell function in the SVZ and restores olfactory neurogenesis and function in aged mice through EGF receptor and PI3K/AKT pathway activation.