Wound Healing and Treatments

Zebrafish larval GPR132b differentially influences wound repair and infection control

This study shows that GPR132b in zebrafish affects wound healing and infection resistance by modulating macrophage activity and lipid signaling pathways.

Development of a 3D in vitro wound healing model to assess the effect of ADSC-EVs on vascularisation

This study develops a 3D multicellular in vitro model to assess ADSC-EVs' impact on vascularisation and wound healing, finding enhanced vessel formation and macrophage co-localisation with EV treatment.

Accelerating Wound Healing Through Deep Reinforcement Learning: A Data-Driven Approach to Optimal Treatment

This paper develops a deep reinforcement learning framework for real-time wound healing treatment optimization, showing 17.71% acceleration in in silico experiments and 40% in vivo.

HERITABLE TISSUE-SPECIFIC GENE EXPRESSION ASSOCIATES WITH CHRONIC WOUND MICROBIAL SPECIES

The paper investigates how genetic regulation of tissue expression influences chronic wound microbiome composition through a microbiome-transcriptome-wide association study.

ECM-Focused Proteomic Analysis of Ear Punch Regeneration in Acomys cahirinus

This study compares ECM proteomic changes during ear punch regeneration in Acomys cahirinus and Mus musculus, identifying differences in ECM proteins, crosslinking enzymes, and CD206 expression.

Xylazine and fentanyl co-administration delays wound healing in mice

This study shows that xylazine and fentanyl co-administration in mice delays wound healing, while neither drug alone does so at tested doses.

Skin Resident T Cell Interactions with NPY1R+ Neurons During Wound Repair Are Impaired by Obesity

This study shows that γδ T cells interact with NPY1R+ neurons in skin during wound repair, and obesity impairs these interactions, suggesting a neuroimmune disruption in wound healing.

Topical Delivery of 4-Aminopyridine Enhances Skin Regeneration in Burn Wounds

This study shows that topical 4-aminopyridine delivered via a gel formulation accelerates burn wound healing by enhancing re-epithelialization, hair follicle regeneration, and fibroblast to myofibroblast transformation.

A microphysiological system of sterile injury demonstrates neutrophil reverse migration via macrophage-derived extracellular vesicle crosstalk.

This paper develops a human microphysiological system to study neutrophil reverse migration mediated by macrophage-derived extracellular vesicles in sterile injury.

Remote-Controlled Wireless Bioelectronics for Fluoxetine Therapy to Promote Wound Healing in a Porcine Model

This paper develops a remote-controlled wireless bioelectronic system for delivering fluoxetine to promote wound healing in pigs, showing improved re-epithelialization and reduced inflammation.

Preprint: Triggered sequential viral-transduction from collagen-based scaffolds for tissue regeneration

The paper develops a collagen-GAG scaffold with ultrasound-triggered sequential release of AAV vectors to promote chronic wound healing.

TGF-β expressed by M2 macrophages promotes wound healing by inhibiting TSG-6 expression by mesenchymal stem cells

This study shows that TGF-β from M2 macrophages inhibits TSG-6 expression in mesenchymal stem cells, promoting wound healing by reducing anti-fibrotic effects.

Senescence-induced reparative fibroblasts enable scarless wound healing in aged murine skin.

This study identifies reparative fibroblasts in aged mice that enhance scarless wound healing through EREG signaling, showing their role in regenerative outcomes.

Modelling the spatiotemporal dynamics of senescent cells in wound healing, chronic wounds, and fibrosis

The paper develops a multi-scale computational model of wound healing that simulates senescent cell dynamics and SASP profiles to understand their role in tissue repair and disease states.

Reactive Oxygen Species Counteract Wound Contraction and Promote Wound Healing

This study shows ROS inhibit myosin phosphorylation to counteract wound contraction, delay closure, and impair regrowth, while chronic ROS depletion alters tissue stiffness and impairs healing.

Reconstituted high-density lipoproteins rescue diabetes-impaired endothelial cell metabolic reprograming and angiogenic responses to hypoxia

This study shows that reconstituted high-density lipoproteins (rHDL) restore impaired PDK4/PDC axis activity and angiogenic responses in diabetic endothelial cells under hypoxia.

Understanding the regulation of chronic wounds by tissue inhibitors of matrix metalloproteinases through mathematical modelling

The paper develops a mathematical model of wound healing dynamics to show that deregulated apoptosis and low TIMP production lead to chronic wounds, and that TIMP-containing hydrogels can reverse them.

Keratinocyte Arginase1 Deficiency Impairs Healing and Antimicrobial Defence against Pseudomonas aeruginosa Infection

This study shows that keratinocyte arginase1 deficiency impairs wound healing and antimicrobial defense against Pseudomonas aeruginosa by reducing epithelial proliferation and anti-microbial peptide production.

Spatial transcriptomic profiling reveals distinct signatures in acute versus chronic wounds through hypergraph modelling and transcriptomic entropy analysis.

This paper uses spatial transcriptomics and hypergraph analysis to identify distinct transcriptomic signatures in acute versus chronic wounds, revealing pathway differences and entropy patterns.

Platelet endocytosis and α-granule cargo packaging are essential for normal skin wound healing

This study shows that platelet granule cargo packaging and endocytosis are essential for proper skin wound healing in mice, affecting multiple phases of the healing process.

Melanization regulates wound healing by limiting polyploid cell growth in the Drosophila epithelium post injury

This study shows that melanization limits polyploid cell growth during wound healing in Drosophila, ensuring efficient wound closure.

Systemic effects of oral tolerance improve the healing of several and concomitant wounds in different body parts

This study shows that oral tolerance to ovalbumin reduces inflammation and improves healing in multiple wounds across different body parts in mice.

A new product containing secretome purified from bovine colostrum, Purasomes IRC100+, in the treatment of vaginal atrophy: in vitro study to evaluate safety and effectiveness

This study evaluates the safety and effectiveness of Purasomes IRC100+, a bovine colostrum secretome product, on vaginal epithelial and fibroblast cells in vitro, showing improved cell viability and migration.

Design and Validation of a Wearable Imaging System for Automated Wound Monitoring in Porcine Model

The paper presents a wearable imaging system for automated wound monitoring in pigs, validated to capture and analyze wound progression using machine learning.

Isotonic medium treatment limits burn wound microbial colonization and improves tissue repair

The paper shows isotonic medium treatment reduces epithelial damage spread and microbial colonization in burn wounds in larval zebrafish and human skin.

Deregulation of epigenetic factor, KDM6A, is involved during Candida albicans mediated delayed wound healing

The paper investigates how KDM6A deregulation contributes to delayed wound healing caused by Candida albicans infection, highlighting its role in modulating metalloproteinase expression.

Alteration of skin fibroblast steady state contributes to healing outcomes

This study identifies pro-regenerative features in TSP2-deficient fibroblasts through single-cell analysis and functional assays, showing enhanced migration, proliferation, and neurogenesis.

Hyaluronic Acid and Emergent Tissue Mechanics Orchestrate Digit Tip Regeneration

This study identifies how tissue mechanics and hyaluronic acid regulate digit tip regeneration by modulating ECM composition and cell behavior.

Deep skin fibroblast-mediated macrophage recruitment supports acute wound healing

The paper identifies deep skin fibroblasts as a source of pro-inflammatory factors that drive macrophage recruitment and support wound healing in mice.

Dermatopontin-expressing fibroblasts mediate an essential skin macrophage niche

This study identifies Dpt+ fibroblasts as essential for maintaining a Csf1-dependent macrophage niche in skin, with implications for wound healing and scleroderma.