Research on Leishmaniasis Studies

Genetic introgression and transcriptomic plasticity are associated with enhanced Leishmania infantum pathogenicity causing human cutaneous leishmaniasis in Tunisia

The paper identifies hybridization between Leishmania species as a driver of pathogenicity shift in Leishmania infantum causing cutaneous leishmaniasis.

MALDI-ToF detection of Leishmania infantum infection in Lutzomyia longipalpis and Nyssomyia neivai

This study uses MALDI-ToF MS to detect Leishmania infantum infection in sandflies, showing that machine learning can accurately distinguish infected from uninfected specimens.

Multi-drug tolerance in Leishmania persister-like cells

The paper identifies persister-like cells in Leishmania that survive antimony treatment and show cross-tolerance to other drugs.

Chemical degradation identified Human p38-MAPK as a host target to combat parasitic infections

This study shows that degrading host p38-MAPK with NR-7h reduces parasite load in Leishmania and Plasmodium infections and enhances antiparasitic therapy when combined with Amphotericin B.

Acriflavine treatment attenuates inflammatory pathology in cutaneous leishmaniasis independently of parasite control

This study shows acriflavine reduces cutaneous leishmaniasis lesion size in mice without affecting parasite burden, by suppressing dendritic cell activation and IFN-gamma-driven immunopathology.

Active transcriptome remodeling and epigenetic adaptations underlie persistence in Leishmania parasites

This study identifies active transcriptome remodeling and epigenetic adaptations in Leishmania persisters, revealing a sophisticated survival strategy rather than passive dormancy.

p1/s1, a 3'-nucleotidase/nuclease, allows Leishmania major to circumvent host innate immune response mechanisms

This study identifies p1/s1, a 3'-nucleotidase/nuclease in Leishmania major, which helps the parasite evade host immune responses by generating adenosine and degrading neutrophil extracellular traps.

microRNA-721 is a host regulator of TNF-IRF1 axis in Leishmania infected macrophage

This study identifies miR-721 as a host regulator that suppresses the TNF-IRF1 axis in Leishmania-infected macrophages, promoting parasite persistence.

Chemical genetics reveals Leishmania KKT2 and CRK9 kinase activity is required for cell cycle progression

This study identifies KKT2 and CRK9 as essential kinases for Leishmania cell cycle progression using chemical genetics and CRISPR-Cas9.

Human sand fly challenge elicits saliva-specific innate and type 1-polarized immunity that promotes Leishmania killing

This study shows that repeated sand fly bites induce immune responses to salivary proteins that enhance Leishmania killing in macrophages.

Cryptic Sex in Leishmania Depends on SPO11 Paralogs

This study identifies the roles of SPO11 paralogs in Leishmania hybridization, showing they are essential for efficient mating and genome segregation.

Genomic Characterization of a Locally Transmitted Leishmania mexicana Isolate from Texas

This study reports the first whole-genome sequence of Leishmania mexicana from a locally transmitted case in Texas, identifying genetic variations and SNPs with potential functional impacts.

Pinus sp. leaf extracts exert antileishmanial effects against Leishmania donovani by targeting trypanothione reductase

This study evaluates the antileishmanial activity of Pinus sp. leaf extracts against Leishmania donovani and identifies compounds that inhibit trypanothione reductase with low cytotoxicity.

Leishmania amazonensis amastigotes invade non-phagocytic cells via highly localized parasite-induced actin remodeling.

This study shows Leishmania amazonensis amastigotes invade non-phagocytic cells through localized actin remodeling and Rho GTPase-driven processes, distinct from promastigote mechanisms.

Glycosomal Aquaglyceroporin 1 Dual Role in Iron Homeostasis and Antimony Susceptibility in Leishmania amazonensis

This study identifies AQP1 in L. amazonensis as a glycosomal protein critical for iron homeostasis, osmoregulation, and antimony susceptibility, with distinct roles compared to other Leishmania species.

Identification, expression and subcellular localization of Leishmania amazonensis and Leishmania infantum Phospholipases A1

This study identifies, characterizes, and localizes PLA1 in Leishmania amazonensis and Leishmania infantum, revealing its association with lipid droplets and suggesting a role in lipid metabolism and pathogenicity.

Targeting Leishmania donovani Sphingosine Kinase 1 using PF-543 enhances immune response and limits parasite load

This paper evaluates PF-543, a SphK1 inhibitor, against Leishmania donovani, showing reduced parasite load and enhanced immune response both in vitro and in vivo.

Leishmania exploits the macrophage endoplasmic reticulum-shaping protein CLIMP-63 to modulate mitochondrial biogenesis and bioenergetics

This study identifies CLIMP-63 as a host factor exploited by Leishmania to modulate mitochondrial biogenesis and bioenergetics during infection.

Ontogeny-independent expression of LPCAT2 in granuloma macrophages during experimental visceral leishmaniasis

The paper uses multimodal imaging and single-cell transcriptomics to identify LPCAT2-mediated membrane remodeling in granuloma macrophages during visceral leishmaniasis.

Human settlement drives population divergence of Leishmania guyanensis at the sylvatic-anthropogenic interface

The paper analyzes Leishmania guyanensis population genomics to show human-driven emergence of a city-proximal population distinct from ancestral sylvatic lineage.

The UTRs of Leishmania donovani vary in length and are enriched in potential regulatory structures

This study annotates UTRs in Leishmania donovani and finds they vary in length and are enriched in G-quadruplex structures, suggesting a key role in post-transcriptional regulation.

Platelet DKK1 promotes tolerogenic dendritic cells and non-healing responses in cutaneous leishmaniasis

This study shows that platelet-derived DKK1 promotes non-healing in cutaneous leishmaniasis by inducing tolerogenic dendritic cells and Th2/Th1-IL-10 responses.

Dynamic phosphoproteomics and proteomics uncover Leishmania donovani-driven ferritin hijacking, contributing to the control of iron homeostasis and iron-related oxidative stress

This study identifies how Leishmania donovani hijacks host ferritin to create an iron reservoir, protecting against oxidative stress and ferroptosis.

Multilocus microsatellite typing (MLMT) reveals high genetic diversity of Leishmania infantum strains causing tegumentary leishmaniasis in northern Italy

The paper uses MLMT to analyze genetic diversity of Leishmania infantum strains causing tegumentary leishmaniasis in northern Italy, revealing distinct genetic populations associated with different clinical forms.

CCL19-CCR7 mediated recruitment of T cells is associated with the leishmanin skin test in individuals with prior exposure to Leishmania parasites

The paper identifies CCL19-CCR7 as a key mediator of T cell recruitment in leishmanin skin test DTH responses using spatial transcriptomic analysis of skin biopsies.

RNA-binding proteins and regulatory networks involved in life-stage, stress temperature, and drug resistance in Leishmania parasites

This paper identifies RNA-binding proteins and regulatory networks in Leishmania parasites across multiple species and conditions, highlighting conserved and lineage-specific RBPs and their roles in life-stage, stress, and drug resistance.

Quantitative proteomics of infected macrophages reveals novel Leishmania virulence factors

This study identifies novel Leishmania virulence factors through proteomics of infected macrophages and presents a database for further research.

Adipose-Derived Extracellular Vesicles Mitigate Experimental Cutaneous Leishmaniasis Through an IL-10 Dependent Mechanism

This study shows that adipose-derived mesenchymal stem cell extracellular vesicles reduce cutaneous leishmaniasis severity through IL-10-dependent immunomodulation without affecting parasite load.

Functional dissection of Leishmania major membrane components in resistance to cholesterol-dependent cytolysins

This study investigates how Leishmania major resists cholesterol-dependent cytolysins by analyzing the role of membrane components in toxin binding and cytotoxicity.

Uptake and survival of Leishmania amazonensis in Acanthamoeba castellanii: An infection organism model?

This study investigates the interaction between Leishmania amazonensis and Acanthamoeba castellanii, showing that the parasite survives inside the amoeba and can be cleared over time, suggesting a potential model for studying leishmanicidal mechanisms.