Research on Leishmaniasis Studies

Distinct neutrophil effector functions in response to different isolates of Leishmania aethiopica

The paper investigates how different Leishmania aethiopica isolates affect neutrophil effector functions in vitro, finding that long-term cultured isolates induce more ROS production and distinct neutrophil populations.

Malnutrition disrupts adaptive immunity during visceral leishmaniasis by enhancing IL-10 production

This study shows malnutrition worsens visceral leishmaniasis by impairing IFN-γ immunity and boosting IL-10, which is reversed by IL-10R blockade.

Mechanism of host cell invasion by Leishmania through KMP-11 mediated cholesterol-transport and membrane phase transition

This paper identifies KMP-11 as a key Leishmania protein that mediates host cell invasion via cholesterol transport and membrane phase transition.

The global dispersal of visceral leishmaniasis occurred within human history

This study shows that the Leishmania donovani species complex dispersed globally within the last 2,000 years, aligning with human migration and colonization.

Scrutinized lipid utilization disrupts Amphotericin-B responsiveness in clinical isolates of Leishmania donovani

This study shows that drug-resistant Leishmania donovani strains exploit host lipids through enhanced endocytosis and lipid droplet accumulation, reducing their responsiveness to Amphotericin-B.

Exploring the Potential of Malvidin and Echiodinin as Probable Antileishmanial Agents Through In Silico Analysis And In Vitro Efficacy

This study evaluates Malvidin and Echioidinin as antileishmanial agents through in vitro and in silico analyses, finding Malvidin more potent and less toxic than Echioidinin and Amphotericin B.

An inhibitor targeting glycosome membrane biogenesis kills Leishmania parasites

This study identifies an FDA-approved inhibitor that targets glycosome membrane biogenesis in Leishmania parasites, effectively killing them including amastigote forms.

Using machine learning to dissect host kinases required for Leishmania internalization and development

This study uses a kinase inhibitor screen to identify host kinases involved in Leishmania uptake and survival in macrophages, revealing both known and novel regulators.

Synthesis and in vitro evaluation shows disquaramide compounds are a promising class of anti-leishmanial drugs

The paper synthesizes and evaluates 24 disquaramide compounds against Leishmania major, finding six significantly reduce parasite numbers without host toxicity.

Measuring the Immune Memory Response of In Vitro Polarized Th1, Th2, and Th17 Cells in the Face of OVA Transgenic Leishmania major in Mouse Model

This study shows that in vitro polarized Th1, Th2, and Th17 cells retain their cytokine profiles when challenged with OVA-expressing Leishmania major, indicating resilience to antigen manipulation.

Proteome profiling of cutaneous leishmaniasis lesions due to dermotropic Leishmania donovani in Sri Lanka

This study uses proteomic profiling to identify 67 differentially expressed proteins in cutaneous leishmaniasis lesions compared to healthy skin, highlighting the integrated endoplasmic reticulum stress response as a key pathway.

Repurposing approved protein kinase inhibitors as potent anti-leishmanials targeting Leishmania MAP kinases

This study identifies sorafenib and imatinib as potential anti-leishmanial drugs by targeting Leishmania MAP kinases, showing anti-proliferative effects and reduced parasitic burden.

A short noncoding RNA modulates gene expression and affects stress response and parasite differentiation in Leishmania braziliensis

This study identifies and functionally characterizes a noncoding RNA in Leishmania braziliensis that influences stress response and parasite differentiation.

Rapid detection, quantification and speciation of Leishmania using real-time PCR and DNA sequencing at the rRNA Internal Transcribed Spacer 2

This study develops PCR and sequencing methods to rapidly detect and differentiate Leishmania species causing human infections.

Integrated surveillance of sandflies as vectors of leishmaniasis reveals the presence of a new Leishmania species with possible implication in human health in Europe

The paper reports the discovery of a new Leishmania species, L. adleri, in sandflies in Spain, highlighting the need for broader surveillance to improve diagnosis and understanding of leishmaniasis in Europe.

Meta-analysis of the pathogen Leishmania donovani transcriptome reveals multiple modes of regulation including two reciprocally regulated gene modules

This study uses meta-analysis of Leishmania donovani transcriptome data to identify co-regulated gene modules and reveals reciprocal regulation between two modules associated with different life phases.

Macrophage-derived developmental endothelial locus 1 (DEL-1) expression promotes an immunoprotective phenotype in experimental visceral leishmaniasis.

This study shows that DEL-1 expression in macrophages reduces parasite burden and granuloma formation in visceral leishmaniasis, promoting an immunoprotective response.

Parasite genetic variation and systemic immune responses are not associated with different clinical presentations of cutaneous leishmaniasis caused by Leishmania aethiopica

This study investigates whether parasite genetic variation or immune responses differ among clinical presentations of cutaneous leishmaniasis caused by Leishmania aethiopica, finding no significant associations.

A comparative genomics approach reveals a local genetic signature of Leishmania tropica in Morocco

The paper sequenced 14 Moroccan Leishmania tropica isolates to study genomic heterogeneity, identifying a core group and two divergent strains with distinct SNP profiles.

Targeting Leishmania infantum Mannosyl-oligosaccharide glucosidase with natural products: pH-dependent inhibition explored through computer-aided drug design.

The paper evaluates natural products for anti-leishmanial activity against Leishmania infantum MOGS using CADD, identifying Ocotillone and Subsessiline as promising candidates with pH-dependent inhibition and favorable ADMET profiles.

Single cell ATAC sequencing identifies sleepy macrophages during reciprocity of cytokines in L.major infection

The paper uses single cell ATAC sequencing to study cytokine reciprocity in L. major infected macrophages, identifying a transient state called sleepy macrophages regulated by NFAT5.

Leishmania parasite arginine deprivation response pathway influences the host macrophage lysosomal arginine sensing machinery

This study shows that Leishmania donovani activates the host SLC38A9 arginine sensing pathway in macrophages, which is critical for maintaining parasite arginine transporter LdAAP3 levels and intracellular growth.

The impact of knocking out the Leishmania major telomerase RNA (LeishTER): from altered cell proliferation to decreased parasite infectivity

This study investigates the role of Leishmania major telomerase RNA (LeishTER) by generating knockout parasites, showing reduced proliferation, telomere shortening, and decreased infectivity.

Ablation of telomerase reverse transcriptase in Leishmania major results in a senescent-like phenotype and loss of infectivity

This study shows that deleting TERT in Leishmania major causes senescent-like traits and reduced infectivity, suggesting it as a potential drug target.

Macrophage metallothioneins participate in the antileishmanial activity of antimonials

This study shows that macrophage metallothioneins (MTs) are involved in antileishmanial activity of antimonials by detoxifying xenobiotics and enhancing parasite killing.

Leishmania Ribosomal Protein (RP) paralogous genes compensate each others expression maintaining protein native levels

The paper investigates compensatory expression of Leishmania ribosomal protein paralogs, showing protein-level compensation without transcript-level changes.

Genomic and epidemiological evidence for the emergence of a putative L. donovani/L. infantum hybrid with unusual epidemiology in Northern Italy

The paper identifies genetic diversity in L. infantum isolates from Italy, revealing hybrid-like genotypes with unusual epidemiology.

Exploring Leishmania linear motifs directing protein secretion, sorting and autophagy

The paper explores Leishmania's protein targeting systems, showing divergence from host organisms and building predictive models for protein localization and function.

Introducing the CRISPR/Cas9 cytosine base editor toolbox "LeishBASEedit" - Gene editing and high-throughput screening in Leishmania without requiring DNA double-strand breaks, homologous recombination or donor DNA

Genome diversity of Leishmania aethiopica

This study analyzes the genome diversity of Leishmania aethiopica, identifying interspecific hybrids and revealing genetic diversity and recombination patterns.