Pancreatic function and diabetes

The paper identifies an inflammatory phenotype in aging human alpha cells and shows calorie restriction reduces inflammation in mice.

This study shows that the SOS1-RAS inhibitor BI-3406 promotes β-cell proliferation and reverses diabetic hyperglycemia in mice.

The paper investigates two unstudied strategies for treating type 1 diabetes using in silico analysis of insulin and insulin-like growth factor 2 expression and function.

This study maps dynamic changes in murine pancreatic islet cell composition and transcriptional states during hyperglycaemia progression using single-cell multi-omics data.

The paper identifies positive selection in insulin, insulin receptor, and inceptor genes in hystricognath rodents, suggesting adaptive changes in the insulin signaling pathway.

This study shows that the α-cell mitochondrial PEP cycle senses amino acids and regulates Ca2+ levels without affecting glucagon secretion.

This study shows that genetic background affects disease penetrance in MafAS64F/+ male mice, with C57 background preventing dysglycemia while mixed background leads to diabetes and beta-cell senescence.

This study shows that de novo ceramide synthesis in beta-cells is essential for normal insulin production and glucose tolerance, as its inhibition leads to reduced beta-cell mass and impaired glucose regulation.

This study shows that GPER signaling maintains β cell identity in female mice, and its loss during menopause may contribute to β cell dysfunction and T2D risk.

The paper shows that Myt3 translation is deregulated in β-cells under obesity-induced stress, leading to β-cell dysfunction and glucose intolerance.

This study shows that enteropancreatic neurons expressing NTSR1 mediate olive oil's effect on glucose tolerance by stimulating insulin release.

The paper identifies senescent β-cell subpopulations in humans and mice that induce pathologic dysfunction through paracrine signaling and shows JAK inhibitors can reverse this effect.

This study investigates how GLP-1R signaling shapes β-cell heterogeneity by analyzing calcium dynamics in islets from different mouse models and humanized KO mice.

This paper presents a method to image insulin secretion and granule dynamics in live pancreatic islets using Zn2+-binding dyes and TIRF microscopy, revealing distinct secretion behaviors of different insulin granule pools.

The paper develops a scalable hydrogel-based vascularized endocrine construct for diabetes treatment, showing sustained glycemic control in preclinical models.

Image analysis of 262,832 pancreatic endocrine objects across 220 donors reveals that small beta-cell-only clusters are abundant in early childhood but virtually absent in type 1 diabetes.

This study shows that intestinal fructose metabolism increases GLP-1 secretion, which enhances insulin release and prevents hyperglycaemia, with this effect being impaired in obese diabetic mice.

The paper uses single nucleus multiomics to study early inflammatory responses in mouse pancreatic islets under high-fat diet, finding proinflammatory gene activation and reduced beta-cell identity.

This study monitors beta cell function in vivo over time, showing hyperglycemia disrupts Ca2+ dynamics and hub cells, while GLP1R agonism restores them.

This paper develops a method to efficiently transduce pancreas tissue slices with CaMPARI2 for analyzing calcium responses, finding size-dependent differences in glucose-induced activity between isolated and slice-islets.

This paper demonstrates that azo-HU308, a light-activatable cannabinoid, optically controls Ca2+ influx in pancreatic β-cells via TRPC channels, not CB2 receptors.

This study identifies MIR192 as a regulator of GLP-1 receptor expression, showing it improves statin-induced impairment of insulin secretion.

The paper introduces an optogenetic tool called the Optopus Box to study pancreatic islet cell communication in a drug-free environment.

This study compares the efficacy of melatonin and GABA monotherapies to their combination in treating T1D and T2D in mouse models, finding monotherapies equally effective.

This study characterizes native human pancreatic mesenchymal stromal cells (npMSCs) in type 1 diabetes, finding increased npMSC density around insulin-containing islets and reduced density around insulin-deficient islets in diabetic individuals.

This study shows lysine enhances insulin secretion through AASS-dependent catabolism, which regulates GABA content and mitochondrial function in beta cells.

This study investigates how arginine vasopressin (AVP) modulates alpha and beta cell activity in pancreatic tissue slices in a glucose-dependent manner, revealing bell-shaped concentration responses and receptor-specific effects.

This study shows ShenQi Compound improves diabetes in GK rats by enhancing mitochondrial energy metabolism and reducing oxidative stress.

The paper shows that glucagon dysfunction in the liver leads to PP cell hyperplasia and the emergence of GCG+ PP+ double-positive cells through hyperaminoacidemia and mTOR signaling.

The paper develops mathematical models of T2D progression using longitudinal data, improving upon the Topp model by incorporating biological mechanisms and nonlinear mixed-effect modeling.