Obsessive-Compulsive Spectrum Disorders

A cross-species assessment of behavioral flexibility in compulsive disorders

This study assesses behavioral flexibility in compulsive disorders across species, finding no consistent link between compulsive behaviors and reduced flexibility, but identifying a subgroup with increased response lability.

Synaptic processes and immune-related pathways implicated in Tourette Syndrome

This study identifies gene sets associated with Tourette Syndrome using genome-wide data, highlighting synaptic and immune-related pathways.

Reduced axon caliber in the associative striatum of the Sapap3 knockout mouse

The study finds reduced axon caliber in the associative striatum of Sapap3-KO mice, affecting signal conduction but not the sensorimotor striatum.

Longitudinal alterations in fronto-striatal glutamate are associated with functioning during inhibitory control in autism spectrum disorder and obsessive compulsive disorder

The paper examines longitudinal changes in fronto-striatal glutamate and its relationship with inhibitory control functioning in ASD and OCD across a one-year period.

Cognitive performance in children and adolescents at high-risk for obsessive-compulsive disorder

The paper investigates cognitive performance in children and adolescents at high-risk for OCD compared to healthy controls, finding impairments in processing speed and IQ discrepancy.

Ketamine increases activity of a fronto-striatal projection that regulates compulsive behavior

The paper shows ketamine increases fronto-striatal circuit activity, reducing compulsive grooming in a mouse model of OCD.

Hippocampal volume in Provisional Tic Disorder predicts tic severity at 12-month follow-up

This study finds that baseline hippocampal volume in children with Provisional Tic Disorder predicts tic severity at 12-month follow-up.

Shared genetic etiology between obsessive-compulsive disorder, obsessive-compulsive symptoms in the population, and insulin signaling

The paper identifies shared genetic risk factors between OCD, population-based OCS, and insulin signaling traits, suggesting a common etiological mechanism.

Central norepinephrine transmission is required for stress-induced repetitive behavior in two rodent models of obsessive-compulsive disorder

The paper investigates the role of norepinephrine in stress-induced repetitive behaviors in OCD models, finding that NE deficiency reduces compulsive behaviors and that restoring NE rescues these behaviors.

Deep brain stimulation modulates directional frontolimbic connectivity in obsessive-compulsive disorder

Deep brain stimulation improves mood and anxiety in obsessive-compulsive disorder by altering connectivity between the amygdala, insula and prefrontal cortex.

The effect of acute stress on the balance between goal-directed and habit networks in obsessive-compulsive disorder.

This study examines how acute stress affects neural network balance in OCD patients, finding blunted connectivity changes in the caudate nucleus linked to compulsivity.

Transdiagnostic phenotyping reveals a range of metacognitive deficits associated with compulsivity

The paper uses a transdiagnostic approach to identify metacognitive deficits linked to compulsivity across psychiatric symptoms.

Not only compulsivity: The SAPAP3-KO mouse reconsidered as a comorbid model expressing a spectrum of pathological repetitive behaviors.

This paper re-evaluates the Sapap3-KO mouse model, revealing a spectrum of pathological repetitive behaviors beyond compulsivity, including tic-like movements and aberrant scratching.

Genetic meta-analysis of obsessive-compulsive disorder and self-report compulsive symptoms.

This paper investigates genetic correlations between compulsive symptoms and OCD using GWAS and finds novel genes and increased enrichment for brain-related genes when combining symptom data with case-control studies.

Increased expression of genetically-regulated FLT3 implicated in Tourette Syndrome

The paper identifies increased FLT3 expression in the dorsolateral prefrontal cortex as associated with Tourette Syndrome through transcriptome-wide association study.

The urge to blink in Tourette syndrome

This study develops a subject-specific model to better interpret blink suppression fMRI data in Tourette syndrome by analyzing blink timing and discomfort during suppression trials.

Transdiagnostic variations in impulsivity and compulsivity in obsessive-compulsive disorder and gambling disorder correlate with effective connectivity in cortical-striatal-thalamic-cortical circuits.

The paper examines how impulsivity and compulsivity dimensions in OCD and GD correlate with CSTC circuit connectivity, finding continuous distributions and shared connectivity patterns across disorders.

Atypical functional connectivity in Tourette syndrome differs between children and adults

This study identifies age-specific functional connectivity differences in Tourette syndrome between children and adults using MRI, showing altered developmental trajectories in affected brain networks.

Dopaminergic drug treatment remediates exaggerated cingulate prediction error responses in obsessive-compulsive disorder

This study investigates dopaminergic modulation of prediction error responses in OCD using fMRI and computational modeling, finding bidirectional remediation of exaggerated cingulate signaling with dopamine agonists and antagonists.

Genome-wide analyses indirectly implicate miRNA regulatory mechanisms in Obsessive-compulsive Disorder psychopathology

The paper investigates miRNA regulatory mechanisms in OCD by analyzing genetic variants from a meta-analysis and identifies potential indirect miRNA targets associated with OCD risk.

Fractionation of impulsive and compulsive trans-diagnostic phenotypes and their longitudinal associations

This study identifies a bi-factor model to fractionate impulsive and compulsive problem behaviors in young adults and finds distinct antecedents for each phenotype.

Concordance Of Genetic Variation That Increases Risk For Tourette Syndrome And That Influences Its Underlying Neurocircuitry

This study identifies genetic overlaps between Tourette Syndrome risk and subcortical brain volumes using GWAS and pleiotropy analysis.

Sex differences in the genetic architecture of obsessive-compulsive disorder

This study investigates sex differences in the genetic architecture of OCD using large-scale genomic data and finds evidence for sex-specific regulatory variant enrichment without genome-wide associations.

Relation between executive functions and polymorphisms in COMT, MAO-A, HTTLPR, SLC1A1 and HT2A in a sample of children with Obsessive Compulsive Disorder

The paper investigates associations between five polymorphisms and executive function tests in children with OCD compared to controls.

Action-outcome knowledge dissociates from behavior in obsessive-compulsive disorder following contingency degradation

This study investigates whether actions in OCD are goal-directed or habitual by manipulating action-outcome contingency, finding that OCD patients show dissociation between explicit knowledge and behavior.

Patterns and predictors of tic suppressibility in youth with tic disorders

This study examines patterns and predictors of tic suppressibility in youth with tic disorders using a pooled dataset, finding that age and tic frequency are associated with better suppression.

Factor Structure and Heritability of Obsessive-Compulsive Traits in Children and Adolescents in the General Population

The paper investigates the factor structure and heritability of obsessive-compulsive traits in children and adolescents using the TOCS, identifying six dimensions and estimating heritability ranges.

De novo damaging coding mutations are strongly associated with obsessive-compulsive disorder and overlap with autism

The paper identifies de novo damaging mutations in OCD and finds overlap with autism genes, suggesting shared genetic risk.

Metacognitive impairments extend perceptual decision making weaknesses in compulsivity

This study shows that compulsivity is linked to reduced metacognitive ability and slower perceptual decision making.

Evolutionary and functional data power search for obsessive-compulsive disorder genes

The paper identifies OCD-associated genes by combining evolutionary and functional data with targeted sequencing in humans and animal models.