Obsessive-Compulsive Spectrum Disorders

Genome-Wide Association Study of Obsessive-Compulsive Symptoms including 33,943 individuals from the general population

This paper conducts a GWAS of subclinical obsessive-compulsive symptoms (OCS) in 33,943 individuals, finding polygenic risk and genetic overlap with OCD.

Mice lacking Ptprd exhibit deficits in goal-directed behavior and female-specific impairments in sensorimotor gating

This study shows that Ptprd knockout mice exhibit deficits in goal-directed behavior and female-specific impairments in sensorimotor gating, suggesting a role for Ptprd in OCD-related traits.

Memory Trace Imbalance in Reinforcement and Punishment Systems Can Reinforce Implicit Choices Leading to Obsessive-Compulsive Behavior

This study models OCD as implicitly learned maladaptive behaviors in reinforcement learning, showing imbalanced memory traces for positive and negative prediction errors, and links this imbalance to OCD symptoms and therapeutic responses.

The rostral zona incerta: a subcortical integrative hub and potential DBS target for OCD

The paper identifies the rostral zona incerta as a subcortical hub with dense connections to cognitive control areas and the lateral habenula, suggesting it as a potential target for deep brain stimulation in OCD.

A cadherin mutation in Celsr3 linked to Tourette Disorder affects dendritic patterning and excitability of cholinergic interneurons

This study shows a CELSR3 mutation linked to Tourette disorder alters dendritic patterning and excitability of cholinergic interneurons in mice without overt behavioral symptoms.

Non-synaptic alterations in striatal excitability and cholinergic modulation in a SAPAP3 mouse model of compulsive motor behavior

This study investigates how SAPAP3 deletion affects striatal circuit function in a mouse model of compulsive motor behavior, revealing non-synaptic and pathway-specific changes.

Closed-loop recruitment of striatal parvalbumin interneurons prevents the onset of compulsive behaviors

The paper shows that activating striatal parvalbumin interneurons at the start of compulsive behaviors reduces these behaviors efficiently using closed-loop optogenetics.

Genome-wide Association Study identifies two novel loci for Gilles de la Tourette Syndrome

This study identifies two novel genetic loci associated with Tourette Syndrome through a genome-wide meta-analysis and integrates functional data to implicate specific genes.

Oligogenic risk model for Gilles de la Tourette syndrome reveals a genetic continuum of tic disorders

The paper constructs an oligogenic risk model for tic disorders using whole-genome sequencing data, revealing a genetic continuum from healthy individuals to severe Gilles de la Tourette syndrome cases.

Independent and distinct patterns of abnormal lateral orbitofrontal cortex activity during compulsive grooming and reversal learning normalize after fluoxetine

The paper investigates LOFC activity during compulsive grooming and reversal learning in OCD models, finding distinct neural patterns that normalize with fluoxetine treatment.

Impaired differential learning of fear versus safety signs in obsessive-compulsive disorder

This study investigates differential learning of fear and safety signs in OCD using Pavlovian conditioning, finding impaired learning during acquisition but not reversal.

A functional network target for tic reduction during thalamic stimulation for Tourette Syndrome

This study identifies functional connectivity patterns associated with tic reduction in Tourette Syndrome patients undergoing thalamic deep brain stimulation.

Investigation of gene-environment interactions in relation to tic severity

The paper investigates gene-environment interactions related to tic severity by analyzing SNPs from GWASs of Tourette syndrome and related disorders in interaction with pre- and perinatal adversity.

Temporal discounting in adolescents and adults with Tourette syndrome

This study investigates temporal discounting in adolescents and adults with Tourette syndrome, finding reduced impulsive choice in adolescents but no differences in adults.

Action inhibition revisited: a new method identifiescompromised reactive but intact proactive control inTourette disorder

This paper introduces a new method to assess inhibitory control in Tourette disorder, finding compromised reactive but intact proactive control.

Model-based learning deficits in compulsivity are linked to faulty representations of task structure

This study links model-based learning deficits in compulsivity to impaired task structure representations, showing weaker action-outcome associations and reduced cognitive control in high-compulsivity individuals.

Parallel valence processing alterations associated with compulsive behavior in SAPAP3 knockout mice and human OCD

The paper assesses valence processing in OCD patients and SAPAP3 knockout mice, finding similar impairments in negative and positive valence processing.

The Development of Cognitive Control in Children with Autism Spectrum Disorders or Obsessive-Compulsive Disorder: A Longitudinal fMRI study

This study uses longitudinal fMRI to examine cognitive control development in children with ASD or OCD and typically developing children, finding similar cognitive control development despite some neural differences in OCD.

Lost in translation: No effect of repeated optogenetic cortico-striatal stimulation on compulsivity in rats

This study failed to replicate compulsive behavior in rats following optogenetic stimulation of the OFC-VMS circuit, unlike previous findings in mice.

Polygenic and environmental determinants of tics in the Avon Longitudinal Study of Parents and Children cohort

The paper investigates how polygenic risk scores and environmental factors contribute to tic occurrence in a cohort study, finding additive and mediated effects.

Examining the neural antecedents of tics in Tourette syndrome using electroencephalography

This study uses EEG to examine neural activity before tics and voluntary movements in individuals with Tourette syndrome, finding differences in mu and beta band oscillations that suggest impaired neuronal inhibition.

Disruption of prepulse inhibition is associated with severity of compulsive behavior and nucleus accumbens dopamine system changes in Sapap3 knockout mice

This study examines the relationship between sensorimotor gating disruption, compulsive behavior, and dopamine receptor levels in Sapap3 knockout mice, finding a correlation between PPI disruption and severe compulsive grooming.

Visuomotor Activation of Inhibition-Processing in Pediatric Obsessive Compulsive Disorder: A Magnetoencephalography Study

This study uses MEG to examine neural activity during a Go/No-Go task in medication-naive OCD youth and typically developing controls, finding altered motor and orbitofrontal cortex responses.

Perseverative behavior under uncertainty is enhanced by tryptophan depletion but diminished with subclinical obsessive-compulsive symptoms

The paper was withdrawn due to substantial changes in results and interpretation after further analysis.

Dissociation of tic expression from its neuronal encoding in the striatum during sleep

This study shows that motor tic expression decreases during sleep in a rat model of chronic tic disorders, while macro-level neural correlates persist and micro-level activity is reduced.

The role of the cingulate cortex in the generation of motor tics and the experience of the premonitory urge-to-tic in Tourette syndrome

This study investigates the role of the cingulate cortex in motor tics and premonitory urges in Tourette syndrome using structural brain imaging.

White Matter Microstructure and its Relation to Clinical Features of Obsessive-Compulsive Disorder: Findings from the ENIGMA OCD Working Group

This study identifies white matter microstructural alterations in adult OCD patients and links them to clinical features, while finding no such abnormalities in pediatric patients.

Transcriptome alterations are enriched for synapse-associated genes in the striatum of subjects with obsessive-compulsive disorder

The paper identifies differentially expressed transcripts in OCD patients' striatum and OFC, showing enrichment for synapse-associated genes and changes in cell type fractions.

Enhanced habit formation in Tourette syndrome : dopamine release and striatal disinhibition modulate shortcut connections in a hierarchical model of cortico-basal ganglia loops

This paper uses a hierarchical neuro-computational model to explore how dopamine and striatal disinhibition contribute to enhanced habit formation in Tourette syndrome.

Genome-wide Association Study of Pediatric Obsessive-Compulsive Traits: Shared Genetic Risk between Traits and Disorder

This study identifies a genome-wide significant variant for OC traits and shows shared genetic risk between OC traits and OCD.