Ion Channels and Receptors

The paper shows that ER morphology affects neuronal bursting by controlling Ca2+ refill rates, linking ER structure to neuronal activity and neurodegeneration.

This study shows that basal cytoplasmic calcium levels regulate C. elegans germ stem cell proliferation through the GON-2 calcium channel and other calcium transport mechanisms.

The paper shows that all extravasating cells form Ca²⁺-dependent membrane blebs, but the source of Ca²⁺ varies by lineage, highlighting distinct regulatory mechanisms.

This study identifies molecular changes in the naked mole-rat that enhance cold sensing through expanded TRPM8 expression and alternative cold detection mechanisms.

This study reveals a structural mechanism for thermosensing in TRPV3 channels, showing that extreme thermosensitivity arises from protein unfolding and dynamic changes rather than localized sensors.

This study presents cryo-EM structures and functional analyses of TRPM8 activation by cold and menthol, revealing mechanisms of cold sensing and menthol specificity.

The paper develops a method to study calcium flux in primary human airway tissue at single-cell resolution using live imaging and machine learning analysis.

This study shows that WS-23, a synthetic coolant in e-cigarettes, disrupts human embryonic cell development by inhibiting pluripotency and inducing endoderm differentiation at nanomolar concentrations.

The paper shows temperature experience modulates transcription and trafficking of thermoreceptors in C. elegans AFD neurons to regulate response plasticity.

The paper identifies a tricellular niche in the cornea involving macrophages, nerves, and Schwann cells that supports Piezo2-mediated touch sensation.

This study shows TNBC cells activate sensory neurons via TRPV1, driving nerve outgrowth and tumor progression, with TRPV1 knockout reducing tumor growth and metastasis.

This study identifies TRPC6 channels as mediators of neuropeptide-induced calcium signaling in VTA-DA neurons, showing state-dependent regulation of reward valuation and consummatory behavior.

The paper identifies two synthetic peptides that potently and selectively modulate ASIC3 activity, showing similar effects but differing in washout kinetics.

This study presents cryo-EM structures of TRPC5 bound to (-)-englerin A, revealing its binding site and mechanism of activation.

The paper identifies a functional interaction between ASIC1a and MCT1 that modulates proton sensitivity and desensitization, showing its role in glioblastoma cell survival and mouse lifespan.

This study shows that Mycobacterium tuberculosis sulfolipid-1 (SL-1) increases TRPV1-positive sensory neuron excitability through Gq/11 pathway activation and intracellular Ca2+ release.

The paper develops a multiscale model showing that increased entropy production in inflamed tissue lowers TRPV1 channel activation temperature, linking thermodynamics to sensory excitability.

The paper identifies a zinc-binding site in the luminal domain of STIM1 that promotes clustering and is essential for calcium influx activation.

The paper investigates the role of TRPV4 and PIEZO2 in axolotl limb regeneration, finding that TRPV4 inhibition reduces limb length without affecting cartilage differentiation.

This study uses cryo-EM and HDX-MS to reveal structural changes in TRPM8 channels that underlie cold sensitivity and menthol activation.

This study shows that Drosophila larval epidermal cells, not nociceptors, mediate heat-induced sensitization to noxious stimuli through thermosensitive calcium responses involving Orai and Stim.

This study shows TRPV4 modulates substrate stiffness sensing and transcellular pore formation in Schlemm's canal cells, with implications for glaucoma treatment.

This study identifies four weak restraints that regulate STIM1 activity to control store-operated calcium entry, showing their concerted action prevents spontaneous activity and enables reversible activation.

This study identifies alternative splicing of TRPA1 as a key mechanism driving reduced electrophile sensitivity in S. flava, enabling adaptation to toxic Brassicales plants.

The paper investigates the cell-specific role of CaV2.2 channels in Trpv1-lineage neurons using Cacna1b gene inactivation and shows their involvement in heat hypersensitivity.

This study shows that calpain cleaves TRPV1's carboxyl terminus, reducing its membrane localization and increasing resistance to tachyphylaxis during repeated capsaicin exposure.

The paper investigates how sensory fibers encode thermal and mechanical nociceptive input in mice, finding that modality separation dominates in the innocuous range while polymodality predominates in the noxious range.

This study identifies a TRPC6 mutation that protects mice from acute lung injury by promoting endothelial regeneration and preventing vascular injury.

This study identifies TRPV4 as the dominant mechanosensor for shear-induced traction responses in endothelial cells, surpassing Piezo1 in both initial traction rise and long-term relaxation.