Tissue Engineering and Regenerative Medicine

Inflammatory Agonists Modulate the Host Response to Type 2 ECM scaffold Immune Environment and Long-Term Remodeling After Severe Traumatic Injury

This study evaluates how inflammatory adjuvants modulate the immune response and long-term remodeling of ECM scaffolds in a murine injury model.

A simple technique to create pre-vascularised delivery scaffolds for organoid therapies

The paper develops a low-cost method to create pre-vascularised scaffolds for organoid therapies, optimising parameters like porosity, lactide-to-glycolide ratio, and cell seeding density using PLGA and R-VECs.

Uniaxial tensile tests and Digital Image Correlation analysis for the mechanical characterization of human Fascia Lata under different decellularization treatments

This study evaluates the mechanical properties of human Fascia Lata after decellularization with three detergents, finding no significant deterioration and highlighting strain inhomogeneity using Digital Image Correlation.

Tissue Engineered Elastic Cartilage-Mimetic Auricular Grafts for Ear Reconstruction

Bioprinted auricular grafts develop native-like elastic cartilage and advance towards a durable therapy for children with microtia.

Exogenous ECM in an environmentally-mediated in vitro model for cardiac fibrosis

This paper develops an in vitro cardiac fibrosis model using exogenous ECM to study how extracellular environment affects tissue formation and cell behavior.

Off-the-Shelf Engineered Liver Tissue Reverses Acute Liver Failure Without Immunosuppression

This paper describes engineered liver tissue that reverses acute liver failure in mice without immunosuppression, demonstrating potential for clinical translation.

A matrix-mimicking bioadhesive epicardium for tunable modulation of biomechanics in the acutely infarcted heart

This paper introduces a bioadhesive epicardium platform that modulates cardiac biomechanics after myocardial infarction in rats.

Decellularized Meniscus (MEND) as a biomaterial that supports stem cell invasion and chondrogenesis

This study develops a decellularized meniscus biomaterial (MEND) that supports stem cell invasion and chondrogenesis, showing comparable performance to existing tissue engineering materials.

Investigation of region-specific effects of pepsin-digested decellularized meniscus on human adipose-derived stromal cells within alginate hydrogels

This study investigates how region-specific decellularized meniscus ECM affects human adipose-derived stromal cell viability and differentiation in alginate hydrogels.

An extracellular matrix coating similar to articular cartilage inhibits the differentiation of myofibroblasts and limits the development of implant-induced fibrosis

This study shows that an extracellular matrix coating similar to articular cartilage reduces myofibroblast differentiation and fibrosis in both in vitro and in vivo models.

Enhanced Kidney Targeting and Distribution of Tubuloids During Normothermic Perfusion

The paper compares methods for delivering tubuloids to kidneys, finding that normothermic perfusion is more effective than in vivo injection for integration and differentiation.

Bioengineered iPSC Vessels Recapitulate Human Vascular Physiological Function and Aging Phenotypes

This paper develops a human vascular model using iPSC-derived cells that mimics vascular aging phenotypes and responds to vasoactive stimuli, showing potential for aging research and drug discovery.

Coaxially Electrospun Myocardial dECM-based Nanofibrous Scaffolds Demonstrate Enhanced Cardiomyocyte Adhesion and Function

This paper develops myocardial dECM-based nanofibrous scaffolds that enhance cardiomyocyte adhesion and function by mimicking native ECM properties.

Evaluation of Tissue-Engineered Blood Vessels as Three-Dimensional In Vitro Testing System in Cardiovascular Research and Device Approval

This study evaluates tissue-engineered blood vessels (TEBVs) as an in vitro model for studying intimal hyperplasia and testing stent designs, finding that endothelialization affects vessel wall thickness and stent performance.

APOE knockout attenuates vascular graft fibrosis by limiting profibrotic macrophage formation through low-density lipoprotein receptor related protein 1

This study shows that APOE knockout reduces vascular graft fibrosis by limiting profibrotic macrophage formation through LRP1, improving aortic compliance and reducing ECM deposition.

The safety and efficacy of Ultrasound Histotripsy and human pluripotent stem cell-derived hepatic spheroid implantation as a potential therapy for treatment of congenital metabolic liver disease: assessment in an immunocompetent rodent model.

This study evaluates the safety and feasibility of combining ultrasound histotripsy with liver organoid implantation in rodents to treat congenital metabolic liver disease.

Vascularized Bioengineered Kidney Using Decellularized Scaffold Recellularized with human Placenta-Derived Angiogenic stem Cells and Kidney Organoids

This study creates a vascularized bioengineered kidney using decellularized scaffolds recellularized with human placenta-derived angiogenic stem cells and kidney organoids, showing successful vascular and renal reconstruction in vivo.

Sweet and sticky: increased cell adhesion through click-mediated functionalization of regenerative liver progenitor cells

This paper enhances cell adhesion and engraftment of hepatic progenitor cells using polysaccharide coatings, improving their interaction with extracellular matrix proteins and endothelial cells.

Uncovering the Regional and Cell Specific Bioactivity of Injectable Extracellular Matrix Biomaterials in Myocardial Infarction through Spatial and Single Nucleus Transcriptomics

This study uses spatial and single nucleus transcriptomics to analyze the regional and cell-specific effects of ECM hydrogel treatments in myocardial infarction, revealing differences in immune modulation and cardiac development between subacute and chronic administration.

Targeted pre-conditioning and cell transplantation in the murine lower respiratory tract

This study demonstrates that targeted pre-conditioning and bronchoscopic cell delivery can effectively regenerate airway epithelium in mice, with transplanted cells differentiating into functional lineages.

Breakthrough in Functional Muscle Regeneration: Biomimetic Collagen Scaffold Restores Abdominal Wall Defects in a VML-rabbit Model

A biomimetic collagen scaffold promotes functional muscle regeneration in a VML rabbit model, achieving complete degradation and tissue replacement without exogenous cells or growth factors.

Scaffold-free cryopreservable cartilage grafts obtained from hiPSC-derived chondroprogenitor cells for airway reconstruction with growth adaptability

This study develops scaffold-free, cryopreservable cartilage grafts from hiPSC-derived cells for tracheal reconstruction, showing growth adaptability and superior performance in animal models.

Neural organoids protect engineered heart tissues from glucolipotoxicity by transferring versican in a co-culture system

This study shows neural organoids protect engineered heart tissues from glucolipotoxicity by transferring versican, identified through co-culture experiments and functional assays.

Engineering Large-Scale and Innervated Functional Human Gut for Transplantation

This paper introduces a confined culture system to generate innervated human gut organoids that mature faster and support transplantation, enhancing engraftment and function.

Muscle-Specific ECM Fibers Made with Anchored Cell Sheet Engineering Support Tissue Regeneration in Rat Models of Volumetric Muscle Loss

This paper develops engineered ECM fibers using Anchored Cell Sheet Engineering to treat volumetric muscle loss in rats, showing improved tissue regeneration and preservation compared to commercial ECM.

Engineering assembloids to mimic graft-host skeletal muscle interaction

The paper develops a 3D in vitro model of graft-host skeletal muscle interaction using decellularized skeletal muscle constructs and neuromuscular organoids, showing functional neuromuscular junction formation and regeneration.

An animal component free bioprocess to synthesize 3D human matrix scaffolds using mesenchymal stromal cells

This paper shows that human mesenchymal stromal cells can produce functional basement membrane proteins without animal components, creating tissue-like scaffolds for bioengineering.

Biofabrication of Small Vascular Graft with Acellular Human Amniotic Membrane: A Proof-of-Concept Study in Pig

This study compares decellularized human amniotic membrane grafts with ePTFE grafts in pigs, finding DAM grafts have better patency, less inflammation, and reduced neointimal hyperplasia in small-diameter vascular surgeries.

Transplantation of bioengineered lung using decellularized mouse lungs and primary human endothelial cells.

This paper describes a method to create bioengineered mouse lungs using decellularized scaffolds and human endothelial cells, followed by orthotopic transplantation.

Volumetric 3D Printing and Melt-Electrowriting to Fabricate Implantable Reinforced Cardiac Tissue Patches

This paper develops a cardiac tissue patch (RCPatch) using 3D printing and melt-electrowriting that withstands mechanical stress and promotes hemodynamic recovery in animal trials.