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intDesc-AbMut: Describing and understanding how antibody mutations impact their environmental interactions

The paper introduces intDesc-AbMut, a tool to automate the analysis of antibody mutations' effects on environmental interactions, achieving high accuracy in predicting crystal-like environments.

De novo design of Ras isoform selective binders

This study designs Ras isoform-specific binders using deep learning to target the C-termini of Ras proteins, enabling specific inhibition and study of their roles in biology and disease.

Low-Cost, Rapid Fabrication of Customizable Polyethylene Glycol-Based Cell Culture Devices

This paper develops a low-cost, rapid method for fabricating PEG-based cell culture devices using 3D printing and PDMS molds, enabling customizable microphysiological systems for tissue engineering.

Comparative proteomic analysis of skin wound healing responses to biomaterial treatments identifies key pathways which govern differential regenerative outcomes

This study compares proteomic responses to three biomaterials during wound healing, identifying key pathways that explain differences in regenerative outcomes.

A Deep Learning-Based Scoring Framework for Large-Scale Multi-Donor Cardiotoxicity Screening

This paper develops a deep learning framework to screen for cardiotoxicity using hiPSC-derived cardiomyocytes, identifying compounds with high toxicity scores and inter-donor variability.

Enzyme-powered DNA origami nanostructures for enhanced mucosal diffusion

This study demonstrates DNA origami nanostructures that use enzymes to enhance mucosal diffusion, showing improved mobility in mucus through controlled enzyme placement.

Vaginal Tissue Engineering via Gelatin-Elastin Fiber-Reinforced Hydrogels

This paper develops and characterizes gelatin-elastin fiber-reinforced hydrogels for vaginal tissue engineering, showing they mimic vaginal mechanical properties and support cell viability in acidic conditions.

Vertically Integrated System for Tracking and Assessing cell-cycle aware phenotypes under confinement

This paper introduces a system to simultaneously track cell migration and cell-cycle phases under confinement, revealing CC-migration correlations and confinement effects on cell behavior.

A Hybrid Modeling Framework for Predictive Digital Twins of CHO Cell Culture

The paper develops a hybrid modeling framework for predicting CHO cell culture digital twins by integrating ODE models, metabolic constraints, and machine learning trained on Bayesian-estimated metabolic rates.

pH-Sensitive Optical Nanocomposites Using Polymer-Coated Gold Nanorods

This paper synthesizes pH-responsive nanocomposites using polymer-coated gold nanorods and demonstrates their optical property changes with pH.

Poly(acrylamido) PEG-alternatives Enhance mRNA-LNP Efficacy in Immune Cells and Evade anti-PEG Antibodies During Repeated Dosing

This study develops PAM-lipids as PEG alternatives for mRNA-LNPs, showing improved transfection in immune cells and evasion of anti-PEG antibodies during repeated dosing.

Endoluminal catheter pulsed field ablation for the treatment of atherosclerotic vascular disease

This paper demonstrates that pulsed field ablation can selectively ablate atherosclerotic plaques while preserving extracellular structure in ex vivo models.

Low-Background Cancer Imaging With a Bioorthogonal Fluorescence Probe and Engineered Reporter Enzyme Bearing a Targeting Moiety

The paper develops a bioorthogonal fluorescence probe and engineered enzyme for low-background cancer imaging in mouse models.

Tunable DNA Origami Nanosensors for Detection of Multiscale Spatial Ion Concentration Gradients

This paper introduces a DNA origami-based sensor (NanoDyn) capable of detecting Na+ ion gradients across multiple spatial scales, demonstrating tunable sensitivity and resolution.

IgA/IgM chromatographic depletion enables efficient 20-nm virus nanofiltration of mini-pool caprylic-acid IgG

This study shows that removing IgA and IgM via chromatography improves nanofiltration efficiency for virus-safe IgG production from plasma.

Evolvoid: A genetic algorithm for shaping optimal cellular constructs

Evolvoid uses genetic algorithms to optimize cellular construct morphology by balancing cell viability and surface energy through a fitness function based on biophysical laws.

Recapitulating Patient-to-Patient Colorectal Cancer Tumor Heterogeneity Using Patient-Derived Xenograft Cells in an Engineered Tissue Model

This study develops 3D-eCRC-PDX tissues to recapitulate patient-specific tumor heterogeneity, showing they maintain growth rates, cell subpopulations, mechanical stiffness, and gene expression profiles.

Induction of meningioma stem signature via hydrogel reprogramming and application of meningioma stem cell marker CXCR4 to pathological diagnosis and treatment.

The paper identifies CXCR4 as a meningioma stem cell marker induced by hydrogel reprogramming and demonstrates its potential for diagnostic and therapeutic applications.

Codon Deoptimization of Multispecific Biologics Reduces Mispairing During Transient Mammalian Protein Expression

This study shows that deoptimizing serine codons in multispecific biologics reduces mispairing and increases protein purity during transient mammalian expression.

Optimized parameters for Cas9 CRISPR interference library design

This study designs an optimized Cas9 CRISPRi library by improving on-target scoring and analyzing off-target effects using updated datasets and methods.