A. Sharma

Human iPSC-Derived Cardiomyocytes are Susceptible to SARS-CoV-2 Infection

This study shows SARS-CoV-2 can infect human iPSC-derived cardiomyocytes in vitro, causing apoptosis and loss of beating, and establishes a model for studying infection mechanisms and drug screening.

A Novel Model of Pancreatic Cancer Dormancy Reveals Mechanistic Insights and a Dormancy Gene Signature with Human Relevance

This study introduces a novel pancreatic cancer dormancy model, identifies a dormancy gene signature, and reveals mechanisms including chromatin remodeling and CCL5 as a novel marker.

Spatial segregation and cooperation in radially expanding microbial colonies under antibiotic stress

This study shows that antibiotic resistance in microbial colonies can be cooperative, with sensitive cells surviving in the presence of resistant cells under antibiotic stress.

Short chain fatty acid butyrate promotes virus infection by repressing interferon stimulated genes

This study shows butyrate promotes virus infection by repressing interferon stimulated genes without disrupting IFN signaling.

Multi-Object Tracking in Heterogeneous environments (MOTHe) for animal video recordings

MOTHe is an open-source tool for tracking multiple animals in natural habitats using a convolutional neural network, demonstrating effectiveness on videos of wasps and antelope.

Membrane constriction and thinning by sequential ESCRT-III polymerization

This study determines the structures of ESCRT-III filaments to show how sequential polymerization by CHMP1B and IST1 drives membrane tubulation, constriction, and thinning.

Non-genetic intra-tumor heterogeneity is a major predictor of phenotypic heterogeneity and ongoing evolutionary dynamics in lung tumors

The paper examines non-genetic intra-tumor heterogeneity in lung tumors, finding it significantly influences phenotypic diversity and evolutionary dynamics beyond genetic factors.

A conserved role of the insulin-like signaling pathway in uric acid pathologies revealed in Drosophila melanogaster

This study shows that the insulin-like signaling pathway influences uric acid metabolism in Drosophila, with conserved effects in humans, and identifies potential therapeutic targets for gout and kidney stones.

Sex differences in seizure at presentation in glioma population

This study examines the association between tumor location and seizure risk in male and female glioma patients.

Sex Differences in Predictors of Seizure in Contrast-Enhancing Gliomas at Clinical Presentation: A Network Approach

The paper uses a machine learning model to predict seizure risk in glioma patients at presentation, finding sex, tumor size, and age as significant predictors.

miRNA-encoded peptide, miPEP858, regulates plant growth and development in Arabidopsis

The paper identifies miPEP858a, a peptide encoded by pri-miR858a, and shows it regulates plant growth, development, and flavonoid biosynthesis through modulation of miR858a and its target genes.

Single-cell analysis of EphA clustering phenotypes to probe cancer cell heterogeneity

The paper develops a single-cell assay to analyze EphA receptor clustering in cancer cells, revealing its persistence through division and association with migration and drug resistance.

Soil salinity inhibits plant shade avoidance

This study shows that soil salinity inhibits plant shade avoidance by interfering with ABA and BR signaling pathways, suppressing PIF function.

Iron nanoparticle-labeled murine mesenchymal stromal cells in an osteoarthritic model persists and demonstrates anti-inflammatory mechanism of action

This study tracks iron nanoparticle-labeled MSCs in an OA model, showing they persist in joints and increase homeostatic macrophages, reducing inflammation.

Multiple human adipocyte subtypes and mechanisms of their development

The paper identifies four human adipocyte subtypes through single-cell transcriptomics and describes their developmental mechanisms and functional roles.

A tunable microfluidic device enables cargo encapsulation by cell- or organelle-sized lipid vesicles comprising asymmetric lipid monolayers

This paper introduces a microfluidic device for creating lipid vesicles with tunable sizes and asymmetric lipid monolayers, capable of encapsulating cargo and supporting membrane processes.

Machine learning enables detection of early-stage colorectal cancer by whole-genome sequencing of plasma cell-free DNA

This paper uses machine learning on whole-genome sequencing of plasma cell-free DNA to detect early-stage colorectal cancer with high sensitivity and specificity.

Gut microbial features can predict host phenotype response to protein deficiency

The paper investigates how gut microbiota differences predict nitrogen balance and growth responses to protein deficiency in mice.

Structural basis for cholesterol transport-like activity of the Hedgehog receptor Patched

This study presents a cryo-EM structure of Patched, revealing its structural similarity to RND transporters and suggesting a role in cholesterol transport.

The maternal effect gene Wds controls Wolbachia titer in Nasonia

The paper identifies a maternal effect gene, Wds, that suppresses Wolbachia titer in Nasonia wasps through genetic and transcriptomic analysis.

Engagement rules that underpin DBL-DARC interactions for ingress of Plasmodium knowlesi and Plasmodium vivax into human erythrocytes

This study provides a structural model of how P. knowlesi and P. vivax DBL proteins interact with human DARC to facilitate red blood cell invasion.