C. Jiang

The basis of a more contagious 501Y.V1 variant of SARS-COV-2

This paper investigates the increased transmissibility of the SARS-CoV-2 501Y.V1 variant due to the N501Y mutation in the Spike protein's RBD and its impact on ACE2 binding and vaccine efficacy.

STING suppresses cancer pain via immune and neuronal modulation

This study shows STING agonists reduce cancer pain and bone destruction in mouse models by modulating neurons, immune cells, and osteoclasts.

The functions of SARS-CoV-2 neutralizing and infection-enhancing antibodies in vitro and in mice and nonhuman primates

This study examines SARS-CoV-2 neutralizing and infection-enhancing antibodies, showing in vitro enhancement does not always lead to in vivo disease enhancement, but can cause increased lung inflammation in monkeys.

Proteasome Regulation by Reversible Tyrosine Phosphorylation at the Membrane

This study identifies a novel mechanism where Src-mediated phosphorylation of Rpt2-Y439 regulates proteasome function at cellular membranes, impacting cancer therapy response.

Direct anabolic three carbon metabolism via propionate to a six carbon metabolite occurs in human heart and in vivo across mouse tissues

The paper confirms the in vivo synthesis of a six-carbon metabolite from propionate in human heart and mouse tissues through non-oxidative pathways.

Non-canonical glutamate-cysteine ligase activity protects against ferroptosis

This study identifies a non-canonical role of glutamate-cysteine ligase in preventing glutamate accumulation and ferroptosis under cystine starvation.

Glycyrrhizin inhibits LPS-induced inflammatory responses in goat ruminal epithelial cells in vitro

This study investigates glycyrrhizin's effect on LPS-induced inflammation in goat ruminal epithelial cells, finding it reduces inflammatory cytokines and protects cell structure.

Structural basis of bile acid receptor activation and Gs coupling

The paper reports cryo-EM structures of GPBAR-Gs complexes, revealing structural features of bile acid recognition, allosteric effects, and biased signaling.

Mechanochemical control of epidermal stem cell divisions by B-plexins

This study identifies B-plexins as critical for mechanosensing in epidermal stem cells, linking mechanical feedback to cell division control during development and in cancer.

Histone loaders CAF1 and HIRA restrict Epstein-Barr virus B-cell lytic reactivation

This study identifies CAF1 and HIRA as host histone chaperones essential for maintaining Epstein-Barr virus latency by restricting lytic reactivation in Burkitt cells.

Boron alters carboxyl group binding capacity and Al transport pathway to relieve Al toxicity

Boron reduces Al binding to pectin carboxyl groups, decreases cytoplasmic Al deposition, and compartmentalizes Al into vacuoles, thereby alleviating Al toxicity in plants.

Non-genetic intra-tumor heterogeneity is a major predictor of phenotypic heterogeneity and ongoing evolutionary dynamics in lung tumors

The paper examines non-genetic intra-tumor heterogeneity in lung tumors, finding it significantly influences phenotypic diversity and evolutionary dynamics beyond genetic factors.

Effects of different dietary NFC/NDF on rumen microbiomes of Karakul sheep based on Three Generations of Full-length Amplifiers sequencing

This study examines how varying levels of dietary NFC/NDF affect rumen microbiomes in Karakul sheep over four periods, finding reduced ruminal pH and bacterial counts with higher NFC/NDF, but no significant changes in dominant bacterial phyla or genera.

Leptin deficient rats develop nonalcoholic steatohepatitis with unique disease progression

This study characterizes LepΔI14/ΔI14 rats as a NASH model through long-term transcriptomic analysis, revealing unique disease progression and gene expression patterns.

iTALK: an R Package to Characterize and Illustrate Intercellular Communication

iTALK characterizes and illustrates intercellular communication in tumor microenvironments using single-cell RNA sequencing data.

Effects of sublethal concentrations and application concentration of SYP-9625 on Tetranychus cinnabarinus (Boisduval) and its natural enemy, Neoseiulus californicus (McGregor)

This study evaluates the sublethal effects of SYP-9625 on Tetranychus cinnabarinus and its impact on the predatory mite Neoseiulus californicus, showing reduced pest population growth and minimal effect on the predator.

Conserved Roles of C. elegans and Human MANFs in Sulfatide Binding and Cytoprotection

This study identifies C. elegans MANF orthologue, shows it binds sulfatide, and demonstrates sulfatide-dependent cytoprotection in both worms and mammalian cells.