S. Jiang

Engineered retrovirus-like nanocarriers for messenger RNA delivery into neurons

This paper develops engineered retrovirus-like nanocarriers for efficient mRNA delivery into neurons by modifying extracellular vesicles with Arc protein capsids and RNA elements.

An mTOR-independent Macroautophagy Activator Ameliorates Tauopathy and Prionopathy Neurodegeneration Phenotypes

The paper identifies CCT020312, an mTOR-independent autophagy activator, which reduces tauopathy and prionopathy neurodegeneration phenotypes by enhancing autophagy flux and clearing protein aggregates.

Targeted degradation of microtubule-associated protein tau using an engineered nanobody-E3 ubiquitin ligase adapter fusion

This paper demonstrates that an engineered nanobody-E3 ubiquitin ligase adapter fusion can effectively degrade tau in mouse neurons by leveraging nuclear proteasomal activity.

Enhancer Reprogramming in Melanoma Immune Checkpoint Therapy Resistance

The paper identifies enhancer-based biomarkers of resistance to anti-PD-1 therapy in melanoma and suggests enhancer blockade combined with ICB as a potential strategy to improve treatment responses.

The porcine cGAS-STING pathway exerts an unusual antiviral function independent of IFN and autophagy

This study shows porcine STING has antiviral activity independent of IFN and autophagy, and also triggers apoptosis to resist viral infections.

Using NAMs to characterize chemical bioactivity at the transcriptomic, proteomic and phosphoproteomic levels

This paper integrates multi-omic data to characterize chemical bioactivity at transcriptomic, proteomic, and phosphoproteomic levels, showing how early phosphoproteomic changes drive downstream effects.

Eating in a losing cause: limited benefit of modified macronutrient consumption following infection in the oriental cockroach Blatta orientalis

This study investigates how bacterial infection affects macronutrient consumption and immunity in Blatta orientalis cockroaches, finding limited immune benefits from dietary shifts.

Cardiac patch treatment alleviates ischemic cardiomyopathy correlated with reverting Piezo1/2 expression by unloading left ventricular myocardium

This study shows cardiac patches reduce ischemic cardiomyopathy by lowering mechanical load and reverting Piezo1/2 expression in the left ventricle.

Development of a Novel Peptide Aptamer that Interacts with the eIF4E Capped-mRNA Binding Site using Peptide Epitope Linker Evolution (PELE).

This paper develops a novel peptide aptamer that binds eIF4E's cap-binding site using PELE, showing nanomolar affinity and intracellular function modulation.

Observing noncovalent interactions in experimental electron density for macromolecular systems: A novel perspective for protein-ligand interaction research

The paper introduces a database of non-covalent interactions in protein-ligand complexes using experimental electron density data and demonstrates its application in studying amide-pi interactions.

Metagenomics revealing molecular profiling of microbial community structure and metabolic capacity in Bamucuo, Tibet

This study uses metagenomics to characterize microbial community structure and metabolic capacity in Bamucuo, Tibet, identifying new species and metabolic pathways.

Broad neutralization of SARS-CoV-2 variants by an inhalable bispecific single-domain antibody

This paper identifies two conserved regions on the Omicron RBD recognized by broadly neutralizing antibodies and develops an inhalable bispecific antibody with broad neutralization and therapeutic efficacy in mice.

Homologous or Heterologous Booster of Inactivated Vaccine Reduces SARS-CoV-2 Omicron Variant Escape from Neutralizing Antibodies

This study shows that homologous or heterologous boosters of inactivated vaccines increase neutralizing antibodies against SARS-CoV-2 Omicron, reducing escape from neutralization.

Identification of a promiscuous conserved CTL epitope within the SARS-CoV-2 spike protein

The paper identifies a conserved CTL epitope in the SARS-CoV-2 spike protein that is compatible with most HLA alleles and suitable for evaluating CD8+ T cell responses.

Aldehyde dehydrogenase 3A1 deficiency leads to mitochondrial dysfunction and impacts salivary gland stem cell self-renewal, differentiation and survival

This study shows that ALDH3A1 deficiency causes mitochondrial dysfunction and impairs salivary gland stem cell self-renewal, differentiation, and survival.

SARS-CoV-2 infects human adipose tissue and elicits an inflammatory response consistent with severe COVID-19

This study shows SARS-CoV-2 infects human adipose tissue, causing inflammation linked to severe COVID-19 outcomes in obese individuals.

KMT2D Loss Promotes Head and Neck Squamous Cell Carcinoma Through Enhancer Reprogramming and Modulation of Immune Microenvironment

This study shows KMT2D loss in HNSCC leads to enhancer reprogramming and immune microenvironment changes, promoting tumor growth through interferon signaling disruption.

Comparison of Wild Type DNA Sequence of Spike Protein from SARS-CoV-2 with Optimized Sequence on The Induction of Protective Responses Against SARS-Cov-2 Challenge in Mouse Model

This study compares a wild-type SARS-CoV-2 spike protein DNA vaccine with an optimized sequence in a mouse model, showing enhanced immune responses and protection against viral challenge.

Spatial epitope barcoding reveals subclonaltumor patch behaviors

The paper develops a method to track subclonal tumor patch behaviors using spatial epitope barcoding and imaging, revealing emergent properties in cancer cell states.

Microbiota responses to different prebiotics are conserved within individuals and associated with habitual fiber intake

The paper investigates how gut microbiota respond to different prebiotics within individuals and links these responses to habitual fiber intake.

Ecological memory of prior nutrient exposure in the human gut microbiome

The paper shows the human gut microbiome retains a memory of past carbohydrate exposures, enhancing future metabolic responses through rapid transcriptional changes.

DCIS genomic signatures define biology and clinical outcome: Human Tumor Atlas Network (HTAN) analysis of TBCRC 038 and RAHBT cohorts

The paper develops a classifier for DCIS recurrence using genomic data from two cohorts and identifies pathways and stroma-specific signatures associated with progression to invasive cancer.

African swine fever virus structural protein p17 inhibits cGAS-STING signaling pathway through interacting with STING

This study identifies p17 as a viral protein that inhibits the cGAS-STING pathway by interacting with STING and disrupting TBK1 and IKKε recruitment.

The African swine fever virus protease pS273R inhibits DNA sensing cGAS-STING pathway by targeting IKKε

This study identifies pS273R as an ASFV protease that inhibits the cGAS-STING pathway by targeting IKKε, revealing a new immune evasion mechanism.

Virus-Dependent Immune Conditioning of Tissue Microenvironments

The paper develops PANINI-MIBI to analyze DNA, RNA, and protein in SIV-infected tissues, revealing IL10 upregulation and macrophage polarization linked to viral latency.

Subventricular zone/white matter microglia reconstitute the empty adult microglial niche in a dynamic wave

The paper depletes adult microglia using CSF1R inhibition and shows that subventricular zone/white matter myeloid cells dynamically repopulate the brain, exhibiting distinct phenotypes from endogenous microglia.

A Safe and Effective Mucosal RSV Vaccine Consisting of RSV Phosphoprotein and Flagellin Variant

This paper develops a mucosal RSV vaccine, P-KFD1, which protects mice against RSV infection without vaccine-enhanced disease and relies on CD4+ T cell responses mediated by IFN-γ or IL-17A.

Discovery and Functional Characterization of Pro-growth Enhancers in Human Cancer Cells

The paper identifies and characterizes pro-growth enhancers in cancer cells using CRISPR screens, finding lineage-specific enhancers associated with poor prognosis and potential therapeutic targets.

High-throughput functional characterization of visceral afferents by optical recordings from thoracolumbar and lumbosacral dorsal root ganglions

The paper develops a cost-effective microscopy system for high-throughput optical recordings of visceral afferent activity in mouse dorsal root ganglia.

Life-history dynamics: damping time, demographic dispersion and generation time

The paper analyzes damping time across 600+ species and finds it scales with generation time, independent of demographic dispersion, suggesting slow life-history species are more vulnerable to disturbances.