Parkinson's Disease Mechanisms and Treatments

Profiling peripheral immune cells in Parkinsons disease: A Scoping Review

This review synthesizes findings on peripheral immune cell changes in Parkinson's disease, identifying common immune signatures and methodological inconsistencies across studies.

"Plasma Membrane Calcium ATPase Downregulation in Dopaminergic Neurons Induces Presynaptic Dysfunction and Neuronal Vulnerability In Vivo and In Vitro"

This study shows that PMCA downregulation in dopaminergic neurons causes calcium dysregulation, presynaptic dysfunction, and increased neuronal vulnerability in Drosophila without overt neurodegeneration.

A 'brain-first' mouse model of progressive alpha-synuclein pathology via intranasal rotenone administration

This study develops a mouse model of Parkinson's disease by intranasal rotenone administration, showing progressive alpha-synuclein pathology from the olfactory bulb to other brain regions.

Axonal dysfunction precedes axonal degeneration in a mouse model of progressive parkinsonism

The paper investigates early axonal dysfunction in a mouse model of Parkinson's disease, finding reduced calcium signals and impaired action potential propagation before axonal degeneration.

Intrinsic dimensionality of deep learning representations reveals cell death-associated heterogeneity in Parkinsons disease iPSC-derived neurons

The paper uses deep learning to identify cell death-related heterogeneity in Parkinson's disease iPSC-derived neurons by analyzing intrinsic dimensionality.

Integrating dorsolateral prefrontal cortex multi-omics and GWAS summary data enhances gene-mapping of Parkinson's disease

This study integrates multi-omics data from DLPFC with GWAS summary data to identify PD risk genes, finding significant overlaps between bulk and cell-type-aware TWAS and PWAS results.

Hyperexcitable primary somatosensory cortex in the MitoPark mouse model of Parkinson's disease

The paper investigates somatosensory cortex changes in MitoPark mice, finding hyperexcitability in regular-spiking neurons and desynchronization in fast-spiking neurons linked to dopamine neuron degeneration.

Altered Striatal Acetylcholine Dynamics in a Model of Parkinson Disease and L-DOPA-induced Dyskinesia

This study investigates how dopamine depletion and L-DOPA treatment alter acetylcholine dynamics in the striatum of a Parkinson's disease model, revealing state-dependent changes in temporal organization of cholinergic signaling.

Selective nigrosome vulnerability in Parkinson's disease revealed by histology-anchored ultra-high-field quantitative MRI

This study uses MRI to show that nigrosomes in Parkinson's patients show specific magnetic properties changes, indicating vulnerability without direct neuronal loss.

Spontaneous eye behavior is an objective marker of parkinsonian severity

The paper shows that spontaneous eye behavior in a nonhuman primate PD model correlates with disease severity and beta oscillatory activity, suggesting it as a potential biomarker.

Peripheral Immune Alterations and T Cell Clonal Dynamics Across the Parkinson's Disease Spectrum

This study uses single-cell RNA sequencing and TCR profiling to analyze immune changes in Parkinson's disease across different stages and identifies sex-dependent immune alterations and TCR diversity.

Cross-species molecular stratification enables T cell receptor diagnosis of Parkinson's disease

This paper stratifies Parkinson's disease patients using T-cell receptor repertoires and develops classifiers that achieve high AUC for subtype diagnosis.

Signed Dopaminergic Asymmetry Tracks Contralateral Motor Laterality in Parkinsons Disease

The paper shows that signed dopaminergic asymmetry correlates with contralateral motor laterality in Parkinson's disease, distinguishing mirror-image and conflicting states from mean-only summaries.

Repeated exposure to viral and bacterial danger signals in Parkin deficient mice induces inflammation but fails to trigger parkinsonism

This study shows that repeated exposure to viral and bacterial danger signals in Parkin-deficient mice induces inflammation but does not cause dopaminergic denervation or motor dysfunction.

Phosphorylation and lipid droplets drive the irreversible phase transition of α-Synuclein in living cells

This study uses an optogenetic system to show that phosphorylation and lipid droplets drive the irreversible phase transition of α-synuclein in cells, leading to neurotoxic aggregates linked to Parkinson's disease.

Cross Dataset Transcriptomic Analysis Identifies Oxidative Stress Inflammation Gene Networks Modulated by Nutrigenomic Interventions in Parkinson Disease

The paper identifies oxidative stress and inflammation gene networks in Parkinson's disease through cross-dataset transcriptomic analysis and nutrigenomic integration, revealing candidate diet-gene associations.

α-Synuclein Seeding in Dopaminergic Neurons Transplanted into the Putamen of Parkinson's Disease Patients

The paper investigates whether α-synuclein seeding from host tissue contributes to Lewy pathology in dopaminergic neuron grafts in Parkinson's disease patients.

Probing the energy landscape of α-Synuclein amyloid fibril formation by systematic K-to-Q mutagenesis

This study uses systematic K-to-Q mutagenesis to probe the energy landscape of α-Synuclein aggregation, identifying core residue mutations that alter free energy pathways and fibril polymorphism.

An atfs-1 loss-of-function screen identifies novel regulators of a-synuclein toxicity in C. elegans dopaminergic neurons

State-selective inhibition of alpha-synuclein aggregation by de novo oligomer-binding proteins

This study designs de novo proteins that selectively inhibit alpha-synuclein aggregation by targeting specific intermediates, with one binder preferentially inhibiting oligomer formation and secondary nucleation.

Label-Free Proteomics of α-Synuclein-Expressing Caenorhabditis elegans Model Uncovers Conserved Pathophysiological Pathways in Parkinson's Disease

This study performs proteomic analysis of a C. elegans model expressing human α-synuclein, identifying conserved proteins linked to PD pathophysiology.

Phosphorylated -Synuclein shapes changes in brain structure, task-related activity and functional connectivity in M83 mice

This study shows that pS129 accumulation in M83 mice leads to structural atrophy, reduced functional connectivity, and hypoactivation in somatosensory areas.

Genomic Landscape of Early-Onset and Familial Latin American Parkinson's Patients

The paper screens variants in PD-related genes in Latin American EOPD and familial PD patients, identifying pathogenic variants and contributing to the genetic characterization of these conditions in the region.

The impact of alpha synuclein overexpression on nigrostriatal transmission

This study investigates how overexpression of wild type alpha synuclein affects nigrostriatal neurotransmission in Parkinson's disease, finding selective deficits in dopamine and glutamate release.

Challenging selective vulnerability in Parkinson's disease: a systematic review and meta-analysis

This paper challenges the assumption of selective vulnerability in Parkinson's disease by analyzing post-mortem data and finding substantial neuronal loss beyond dopaminergic and pigmented populations.

Cryo-EM Structures of Infectious Low-Twist α-Synuclein Filaments in Lewy Bodies

The paper determines cryo-EM structures of low-twist α-synuclein filaments from Lewy bodies and shows they share a structural core with high-twist forms.

Lysosomal polygenic risk score in Parkinson's disease across populations.

This study evaluates the performance of a lysosomal polygenic risk score (lyso-PRS) for Parkinson's disease risk across populations and its association with clinical outcomes in Europeans.

Exosomal miR-23a release coincides with astrocytic calcineurin activation, protects neurons from apoptosis by regulating NOXA in Parkinson's disease models and is enriched in the plasma of patients with Parkinson's disease

This study identifies exosomal miR-23a release from astrocytes as a neuroprotective mechanism in Parkinson's disease, linked to calcineurin activation and reduced neuronal apoptosis, with elevated levels observed in patient plasma.

Aβ42-Driven α-synuclein Fibril Polymorphism and Distinct Intracellular Aggregation

This study shows that Aβ42 monomers and preformed fibrils differentially affect α-synuclein fibril formation, structure, and neuronal toxicity.

Dopamine Agonists in Parkinson's Disease Decouple Risk-Taking from Reward-Paired Cues by Enhancing Risky Choice in Their Absence

This study shows that dopamine agonists combined with levodopa increase risky choices in Parkinson's patients even without reward-paired cues.