Alzheimer's disease research and treatments

This study identifies cell-type-specific and shared gene regulatory networks modulating APOE expression in microglia and astrocytes using single-cell RNA sequencing data from AD patients.

The paper investigates proSAAS's role in homeostatic scaling and its effect on amyloid plaques in 5xFAD mice, finding increased secretion and reduced plaque size with proSAAS overexpression.

This study investigates the role of 10 VEGF genes in Alzheimer's disease using single-nucleus RNA sequencing, finding altered expression and associations with disease endophenotypes.

This study shows ACSS2-mediated histone acetylation is critical for learning and memory in a mouse AD model, with acetate supplementation rescuing deficits.

This study compares two VLP-based vaccines targeting different pTau epitopes, finding that the PHF1 vaccine reduces tau pathology and restores cognition better than the AT8 vaccine in a mouse model.

This study identifies PTPσ as a critical regulator of Alzheimer-related pathologies by modulating APP proteolytic metabolism and downstream pathogenic processes.

This study uses AI simulations to examine how APOE genotypes influence Alzheimer's progression in virtual patients, identifying early biomarkers and disease patterns.

This study shows APOE regulates GM1 transport, which influences Aβ aggregation, linking APOE to Alzheimer's disease etiology.

The paper reports that tau filaments in vacuolar tauopathy with VCP mutation D395G have the CTE fold, similar to environmentally induced diseases.

The paper shows that circular RNAs targeting PKR reduce neuroinflammation and amyloid-beta plaques in AD mouse models.

This study identifies oncogenic MET signaling activation in aged Sgo1-/+ mice brains, linking it to Alzheimer's Disease pathology and suggesting potential drug repurposing.

The paper shows a D-peptide disassembles AD-tau fibrils via a strain-relief mechanism involving oppositely twisted fibrils.

The paper examines how tau-pathology disrupts hippocampal neural activity patterns in mice, revealing structural disarray in spike trains and oscillatory fields that correlates with age and spatial navigation deficits.

This study uses transgenic porcine models to show that APP and its AICD domain modulate AD-related gene networks through interactions with signaling proteins.

The paper identifies three tobacco-derived compounds with neuroprotective effects against Alzheimer's disease using a genetic engineering approach with neural progenitor cells.

This study examines how extracellular tau aggregates affect mitochondrial function in neurons and astrocytes, revealing cell-specific responses and potential therapeutic targets.

The paper identifies immune signatures predicting changes in neural circuit activity in a mouse Alzheimer's model.

This study shows that lowering glucose increases Aβ levels in mouse brain slices and human cells, likely via BACE1 activation, but not in hypoxia conditions.

The paper examines molecular and pathological changes in the suprachiasmatic nucleus across Alzheimer's disease stages, finding SCN-specific tau pathology and immune dysregulation.

This study examines the effects of dietary methionine restriction on cognitive and behavioral phenotypes in a mouse model of frontotemporal dementia, finding improvements in motor function and memory in aged mice.

This study identifies genetic comorbidities and potential biomarkers for Alzheimer's disease through pleiotropy analysis and functional network studies.

The paper examines increased P2X7R levels in Alzheimer's disease hippocampi, correlating with amyloid and tau pathologies, and identifies its potential as a neuroinflammation marker.

This study shows that Oolonghomobisflavans reduce tau fibrils and improve health in Alzheimer's models.

The paper analyzes bulk RNA-seq data from diverse ethnic groups to identify differentially expressed genes and pathways in Alzheimer's Disease, highlighting cross-ethnic and ethnic-specific findings.

This study shows that reducing Fshr expression in Alzheimer's mice improves spatial memory, with gene-dose-dependent effects, and links low FSH levels to better memory retrieval.

The paper identifies six genetic loci associated with Alzheimer's disease in Hispanics, showing both genetic and epigenetic risks, with some downstream effects on mRNA expression being ethnicity-specific.

This study shows that boosting mitochondrial bioenergetics enhances autophagy and clears pathological tau in tauopathy neurons, suggesting a new therapeutic approach for Alzheimer's and other tauopathies.

This study identifies APP's role in extracellular disposal of nuclear waste, showing its impairment in Alzheimer's disease and suggesting it as a therapeutic target.

This study shows Src kinase is upregulated and phosphorylated in Alzheimer's disease, interacts with Tau, and may be a therapeutic target.

This study compares the effects of Aducanumab and Lecanemab on intraneuronal Aβ42 and phosphorylated Tau in Alzheimer's Disease using human neurons derived from patient fibroblasts.