Mosquito-borne diseases and control

JEV helicase targets host MTOC and participates in the organization of pericentriolar viroplasm

This study identifies JEV helicase's role in targeting host MTOCs and forming pericentriolar viroplasm, revealing centrosome-cytoskeleton interactions in viral infection.

From Bird Viremia to Bird Surveillance: Identifiability in a Multiscale Vector-Borne Model of Usutu Virus Infection

This study develops a multiscale vector-borne model of Usutu virus infection and validates it using laboratory and surveillance data, showing improved parameter identifiability through multiscale fitting.

An Eco-Evolutionary Modelling Framework for Mosquito Host Specialisation

This paper develops an eco-evolutionary model to explain mosquito host specialisation, showing it is environmentally gated and influenced by resource availability and seasonality.

Vector Competence of Temperate and Tropical Mosquito Species for Babanki virus

This study assesses the vector competence of temperate and tropical mosquito species for Babanki virus, finding high infection and dissemination rates in multiple species.

Orthoflaviviruses use diverse binding modes to engage LDLR family receptors

This study determines cryo-EM structures of orthoflaviviruses bound to LDLR family receptors, revealing distinct binding modes and receptor engagement mechanisms.

Mosquito population control by aquatic predators: a global meta-analysis of predation efficacy by fish and odonate naiads

This paper evaluates global mosquito predation by aquatic predators, finding that dietary specialization, not taxonomy, predicts predation efficacy, and that body size and experimental duration significantly affect consumption rates.

Integrated Clinical and Proteomic Precision Subgrouping for Severe Dengue Endotype Signature

The paper identifies molecular signatures and endotypes in severe dengue by integrating clinical and proteomic data, revealing immune pathways associated with severe disease.

Enhanced early IgG-mediated complement deposition in the development of chronic chikungunya virus disease

The paper investigates IgG-mediated complement deposition in chronic chikungunya virus disease and finds enhanced complement activation correlates with disease progression.

Efficacy of an attractive lethal ovitrap to reduce populations of Aedes mosquitoes: a controlled trial in Iquitos, Peru

This study evaluates an attractive lethal ovitrap (ALOT) to reduce Aedes aegypti populations and dengue incidence in Iquitos, Peru, showing a 56% reduction in symptomatic dengue cases.

Drought dynamics explain once in a century yellow fever virus outbreak in Brazil with implications for climate change

This study links a drought-driven yellow fever virus outbreak in Brazil to changes in mosquito and primate behavior, showing that multiple interventions were key to ending the epidemic.

pr-independent biogenesis of infectious mature Zika virus particles

This study shows that Zika virus particles can form without the prM protein and proteolytic activation, and M-E vaccines induce neutralizing antibodies regardless of maturation state.

Species-specific susceptibility and low transmission of the historical Japanese encephalitis virus Nakayama strain in North American Culex mosquitoes

This study assesses the vector competence of North American Culex mosquitoes for the JEV Nakayama strain across temperatures, finding low but non-zero transmission potential with Cx. pipiens as the most permissive species.

Nuclear activities and interactome of the NS5 protein of Tick-Borne Encephalitis Virus

This study identifies the nuclear localization and interactome of TBEV NS5 protein, revealing its role in modulating viral replication through interactions with nuclear factors.

Spondweni virus infection in pregnant rhesus macaques causes placental pathology without apparent fetal harm

This study infects pregnant rhesus macaques with Spondweni virus and finds placental pathology without fetal harm, contrasting with ZIKV-DAK-induced fetal demise.

Thermal fertility limits reveal underestimated climatic suitability for Aedes aegypti in temperate regions

This study shows that thermal fertility limits in Aedes aegypti are more restrictive than lethal temperature limits, affecting climatic suitability predictions for mosquito distribution and disease risk.

Mosquito infection-mediated trait variation alters temperature-dependent transmission of West Nile virus

The paper examines how WNV infection and temperature interact to affect mosquito traits and transmission potential, finding infection alters thermal performance and reduces estimated transmission intensity.

The extrinsic incubation period for Zika virus: a Bayesian time delay modelling study

This paper estimates the temperature-dependent extrinsic incubation period (EIP) for Zika virus using Bayesian models, finding non-linear declines in EIP with increasing temperature and longer EIPs in Ae. albopictus than Ae. aegypti.

End-of-outbreak determination under seasonal transmission

This study develops a seasonal transmission model to determine when it is safe to relax interventions at the end of an outbreak, showing that incorporating seasonality allows for earlier intervention relaxation.

The Effects of Mean Temperature and Diurnal Temperature Range on West Nile Virus Transmission

This study shows that fluctuating temperatures affect West Nile virus transmission dynamics differently than constant temperatures, with implications for epidemiological modeling.

A pro-apoptotic selection strategy enables CRISPR screening in mosquitoes and identifies Lachesin as a chikungunya virus entry factor

The paper uses a pro-apoptotic CRISPR screening strategy in mosquito cells to identify Lachesin as a critical CHIKV entry factor.

Not all West Nile virus lineages behave alike: vector competence and minimum infectious dose differences between lineages 1 and 2

This study compares transmission efficiency and infectious dose requirements of West Nile virus lineages 1 and 2 in different mosquito species.

Sequence Homology and Tissue Tropism Determine Superinfection Exclusion of Zika virus in Aedes aegypti Mediated by an insect-specific Binjari-Zika Virus Chimera

Aedes albopictus and dengue transmission risk in France over the 21st century

This study assesses how climate change affects Aedes albopictus distribution and dengue transmission risk in France through 2100 using climate models and demographic scenarios.

Molecular Analysis and Computational Modeling Reveal Temporally Separable Responses triggered by DENV-Induced Soluble Factors in Endothelial Cells

The paper investigates CMDV-induced changes in endothelial cells using molecular analysis and computational modeling, identifying key genes and pathways involved in endothelial dysfunction during severe Dengue.

Molecular basis for chikungunya virus recognition of a mosquito-specific receptor

This study identifies the molecular basis of chikungunya virus recognition of the mosquito-specific receptor Lachesin using cryo-EM structures and shows a Lachesin polymorphism that blocks virus entry.

Zika virus NS3 drives the assembly of a viroplasm-like structure

This paper shows that ZIKV NS3 can drive the formation of a viroplasm-like structure in human cells, with the helicase domain being critical for this process.

Passive copper release from ornamental rain chains is harmful to mosquito larvae and deters egg-laying

This study shows that copper from rain chains harms mosquito larvae and deters egg-laying in both field and lab settings.

Lachesin is a mosquito receptor for multiple arthritogenic alphaviruses

This study identifies Lachesin as a mosquito receptor for multiple arthritogenic alphaviruses using CRISPR screening in Aedes albopictus cells.

Serotypes of Dengue Virus and Kdr Mutations F1534C, S989P, V410L, V1016I, and V1016G in Aedes aegypti and Aedes albopictus Mosquitoes from the commune of AbomeyCalavi, Southern Benin

This study identifies dengue virus serotypes and kdr mutations in Aedes mosquitoes from Abomey-Calavi, Benin, finding DENV-3 as the most common serotype and multiple kdr mutations, though no association with dengue infection was observed.

Highly Conserved Core Residues Define Old-World Alphaviruses and Trace Early Evolutionary Divergence

The paper identifies conserved residues in Old-World alphaviruses that govern capsid structure and traces their evolutionary divergence, suggesting reduced assembly efficiency in New-World lineages may contribute to attenuation.