Developmental Biology and Gene Regulation

The paper analyzes transcriptomes of somatic cell populations in Drosophila testis to link metabolism and stemness, identifying gene expression patterns and signaling pathway differences.

This study shows that Notch dimerization is critical for intestinal homeostasis and immune responses, with mite infestation worsening related phenotypes and triggering lymphoma in mutant mice.

The paper shows that Escargot regulates antennal and labial disc development in Drosophila through two distinct pathways involving DE-cadherin and Dpp.

This study shows Foxg1 is essential for upper jaw development by repressing lower jaw fate, regulating apoptosis, and organizing the cephalic ectoderm.

The paper identifies Tailless as a master regulator maintaining neuroblast identity and shows its inactivation stabilizes intermediate progenitor commitment during neurogenesis.

This study shows HIF-2α regulates neural crest stemness and development, with implications for neuroblastoma.

The paper shows zebrafish primordial germ cells use germ plasm in two phases to regulate transcriptome divergence from somatic cells through post-transcriptional mechanisms and chromatin changes.

The paper identifies new gene expression domains in butterfly venation patterning genes and proposes evolutionary mechanisms for simplified venation in Drosophila.

This study generates a Waddington epigenetic landscape for the early C. elegans embryo, identifying key genes involved in shaping developmental trajectories.

The paper shows that slower human embryonic development compared to mice is due to higher protein stability and longer cell cycle duration in human cells.

This study shows that the Drosophila transcription factor broad regulates leg disc morphogenesis by controlling ECM remodeling, cell shape changes, and metabolic activity during metamorphosis.

The paper introduces a CDK sensor to distinguish cycling cells from terminally differentiated cells in C. elegans and zebrafish, revealing commitment points and stochasticity in cell cycle control.

The paper identifies integrin-alpha-6+ stem cells as essential for whole body regeneration in the invertebrate chordate Botrylloides diegensis.

The paper investigates the distinct developmental roles of MLL3 and MLL4 in mice, finding MLL4 is critical for early embryonic migration while MLL3 is needed for lung maturation.

This study uses cell-based simulations to show that Notch signalling in developing pancreatic tissue is influenced by geometric effects and ligand expression changes, leading to distinct cell differentiation patterns.

The paper shows that NODAL-SMAD2/3 signaling levels determine gene transcription by modulating SNON degradation via Arkadia, leading to level-specific cell-fate decisions.

The paper identifies damage-responsive, maturity-silenced enhancers that control regenerative capacity in Drosophila imaginal discs and shows their regulation by chromatin factors.

The paper shows that egg activation triggers the degradation of maternally deposited RNA binding proteins via the ubiquitin-proteasome system, mediated by Kondo and CTLH ligase.

This study compares molecular and morphological signatures in two developmental pathways of tunicates, finding distinct molecular programs but shared stem cell profiles.

This study shows that dynamic changes in cell size during early zebrafish development are critical for proper gastrulation, with altered cell sizes leading to migration defects and embryonic abnormalities.

The paper shows Shh signaling drives tissue shear and cell rearrangements in the presomitic mesoderm, contributing to boundary formation.

The paper measures the effect of Roscovitine on mPSM explants using a real-time reporter, finding increased oscillator period and differentiation rate, consistent with the clock and wavefront model requiring increased wavefront velocity.

The paper identifies two LIN-29 isoforms that regulate distinct aspects of the juvenile-to-adult transition in C. elegans through differential spatiotemporal expression and regulatory control by LIN-28, LIN-41, and HBL-1.

The paper identifies genes controlling limb skeletal proportion differences between mouse and jerboa by comparing transcriptomes of growth cartilages and finding species-specific expression patterns.

The paper shows that polarity protein distribution in Drosophila embryos regulates hexagon dominance in plasma membrane organization during syncytial division cycles.

The paper shows that zebrafish embryos can break symmetry autonomously when isolated, indicating that extra-embryonic tissues are not strictly required for early patterning.

This study develops a computational framework to reconstruct phase dynamics of the somitogenesis clock oscillator using empirical mode decomposition and validates it with synthetic data and real-time reporter signals.

This study identifies desmogon as essential for vacuolated cell shape and notochord morphology in Medaka, revealing developmental heterogeneity and injury sensing mechanisms.

The paper demonstrates that the Dorsal/NF-κB morphogen gradient in Drosophila embryos is established via shuttling by Cactus/IκB, enabling viability of embryos with one maternal copy of dorsal.

The paper investigates dynamic feedback between tissue growth and neural crest cell migration during chick head morphogenesis using time-lapse imaging, modeling, and perturbations, revealing its role in robust craniofacial development.