Cannabis and Cannabinoid Research

Cannabis use, depression and self-harm: phenotypic and genetic relationships

The paper examines phenotypic and genetic relationships between cannabis use, depression, and self-harm using UK Biobank and consortium data, finding associations and genetic correlations.

DMSO potentiates the suppressive effect of dronabinol, a cannabinoid, on sleep apnea and REM sleep

The paper tests if DMSO enhances dronabinol's effects on sleep apnea and REM sleep in rats, finding DMSO potentiates some effects but not others.

Top-down control of water intake by the endocannabinoid system

The paper identifies a circuit involving endocannabinoid modulation of excitatory projections from the anterior cingulate cortex to the basolateral amygdala that promotes water intake.

Patterns and perceptions of cannabis use with physical activity

This study surveys cannabis use patterns among physically active individuals, finding that most use cannabis before exercise and believe it enhances performance.

The C-terminal Helix 9 motif regulates cannabinoid receptor type 1 trafficking and surface expression

This study identifies the C-terminal Helix 9 domain of CB1R as critical for its axonal surface polarity, stability, and signaling efficiency.

Cue-reactivity in the ventral striatum characterizes heavy cannabis use, whereas reactivity in the dorsal striatum mediates dependent use

This study examines cue-reactivity in striatal regions of heavy cannabis users to differentiate between addiction-related and exposure-related adaptations.

Δ9-tetrahydrocannabinol Attenuates Oxycodone Self-Administration Under Extended Access Conditions

This study investigates whether THC reduces oxycodone self-administration in rats under extended access conditions and finds additive antinociceptive effects when THC and oxycodone are combined.

Research grade marijuana supplied by the National Institute on Drug Abuse is genetically divergent from commercially available Cannabis

This study finds that NIDA-supplied research grade marijuana is genetically distinct from most commercial Cannabis, grouping more with hemp and a small subset of commercial drug-type Cannabis.

Genetic, epigenetic and pharmacological influences modulating tissue specific regulation of the cannabinoid receptor -1 (CB1) gene; implications for cannabinoid pharmacogenetics.

The paper investigates genetic and epigenetic factors influencing CB1 gene regulation and their impact on cannabinoid pharmacogenetics through cell-specific functional studies.

Sex differences in the behavioral and synaptic consequences of a single exposure to cannabinoid at puberty and adulthood

This study examines sex differences in behavioral and synaptic effects of a single cannabinoid exposure at puberty and adulthood in rats.

Dual mechanism of TRKB activation by anandamide through CB1 and TRPV1 receptors

This study shows anandamide activates TRKB through CB1 and TRPV1 receptors, influencing neuronal migration and behavior in rat cortical cells.

Cannabis Use in Youth is Associated with Limited Alterations in Brain Structure

This study finds no significant differences in brain structure between adolescent and young adult cannabis users and non-users using high-resolution MRI scans.

Impaired cognitive performance under psycho-social stress in cannabis-dependent males is mediated by attenuated precuneus activity

This study finds that cannabis-dependent males show impaired cognitive performance under psycho-social stress, linked to reduced precuneus activity and altered connectivity with the dorsal medial prefrontal cortex.

Altered Reward Processing in Abstinent Dependent Cannabis Users: Social Context Matters

This study shows that cannabis dependence in men reduces reward experience during female social interaction compared to male interaction, with neural changes linked to cannabis exposure.

A comparative analysis of cannabis and tobacco smoke exposure on human airway epithelial cell gene expression, immune phenotype, and response to formoterol and budesonide treatment

This study compares the effects of cannabis and tobacco smoke on human airway epithelial cells, showing similar impairments in barrier function and antiviral responses, with no benefit from formoterol/budesonide treatment.

Δ9-tetrahydrocannabinol negatively regulates neurite outgrowth and Akt signaling in hiPSC-derived cortical neurons.

This study shows that Δ9-THC inhibits neurite outgrowth and Akt signaling in hiPSC-derived cortical neurons via CB1R activation.

A complete Cannabis chromosome assembly and adaptive admixture for elevated cannabidiol (CBD) content

Nanopore chromosome assembly of high-CBDA cultivar CBDRx places cannabinoid synthase genes in three linked chromosome 9 regions; CBDA synthase and the THC/CBD QTL sit in hemp-derived sequence.

Sex specific endophenotypes of in-utero cannabinoid exposure

This study investigates sex-specific behavioral and neuronal deficits in adult rats exposed to prenatal cannabinoids, finding differences in social interaction, synaptic plasticity, and receptor expression between males and females.

Tolerance to hypothermic and antinoceptive effects of∆9-tetrahydrocannabinol (THC) vapor inhalation in rats

This study investigates tolerance to THC's hypothermic and antinociceptive effects in rats through repeated vapor inhalation, finding gender differences in tolerance development.

Maternal cannabinoid exposure during lactation alters the developmental trajectory of prefrontal cortex GABA-currents in offspring

This study shows that maternal cannabinoid exposure during lactation delays the GABA switch in prefrontal cortex neurons of rat offspring via a CB1R-dependent mechanism.

Selective and context-dependent social and behavioral effects of Δ9-tetrahydrocannabinol in weakly electric fish

This study investigates the context-dependent effects of THC on social and behavioral traits in weakly electric fish using various behavioral paradigms.

Rare genetic variants in the endocannabinoid system genes CNR1 and DAGLA are associated with neurological phenotypes in humans

The paper identifies rare variants in CNR1 and DAGLA genes linked to neurological phenotypes in humans, with CNR1 variants associated with pain, sleep, and memory issues, and DAGLA variants linked to seizures and developmental disorders.