Cannabis and Cannabinoid Research

An unconventional GABAergic circuit differently controls pyramidal neuron activity in two visual cortical areas via endocannabinoids

The paper identifies a differential role of CB1-expressing interneurons in controlling pyramidal neuron activity in primary and secondary visual cortical areas through distinct endocannabinoid mechanisms.

Explainable Machine Learning Analysis Reveals Gender Differences in the Phenotypic and Neurobiological Markers of Cannabis Use Disorder

The paper uses explainable machine learning to identify gender-specific risk factors for cannabis use disorder, finding stronger environmental influences in women and individual factors in men.

Genetic modulation of initial sensitivity to Δ9-tetrahydrocannabinol (THC) among the BXD family of mice

The paper quantifies heritability of THC responses in BXD mice strains and identifies candidate genes associated with variation in initial sensitivity to THC effects.

Genomic and Chemical Diversity of Commercially Available Industrial Hemp Accessions

The paper assesses the genetic and chemical consistency of CBD hemp accessions, finding significant variability and reliability issues in commercial varieties.

Deep learning and cross-species analysis identify the influences of sex and cannabinoidsignaling on cerebellar vermis morphology

The paper uses deep learning to analyze cerebellar morphology across species, finding sex and cannabinoid signaling influence folding patterns.

Prediction of Essential Binding Domains for the Endocannabinoid N-Arachidonoylethanolamine (AEA) in the Brain Cannabinoid CB1 receptor

The paper predicts essential binding domains of AEA in the CB1 receptor using molecular dynamics simulations, identifying the hydrophobic channel and H2/H3 region as critical for AEA binding.

A low repeated dose of Δ9-tetrahydrocannabinol affects memory performance through serotonergic signalling in mice

This study shows that repeated low-dose THC impairs memory in mice through serotonergic signaling via 5-HT2ARs, as evidenced by increased CB1R/5-HT2AR heterodimers and reduced LTP.

Cnr2 is important for Ribbon Synapse Maturation and Function in Hair Cells and Photoreceptors

This study shows that cnr2 is critical for ribbon synapse maturation and function in hair cells and photoreceptors, affecting synaptic structure and behavior in zebrafish larvae.

Cannabinoid signaling promotes the reprogramming of Muller glia into proliferating progenitor cells.

This study investigates the role of the endocannabinoid system in reprogramming Muller glia into progenitor cells in the retina, showing that eCB signaling promotes this process while suppressing NFkB activity in mouse Muller glia.

Endocannabinoids and dopamine balance basal ganglia output

This study shows that endocannabinoids and dopamine interact to modulate long-term plasticity in the entopeduncular nucleus, influencing the balance of direct and indirect output dominance.

Targeting Diacylglycerol Lipase to Reduce AlcoholConsumption

This study shows that inhibiting diacylglycerol lipase reduces alcohol consumption in preclinical models and prevents ethanol-induced suppression of GABAergic transmission without causing anxiety or depression.

Cannabidiol effects on cocaine-seeking behaviour and incubation of craving in mice.

This paper develops a mouse model to study cocaine-seeking behavior and incubation of craving, finding that cannabidiol reduces cocaine self-administration but not craving incubation, depending on administration timing.

Individual and combined effects of Cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC) on striato-cortical connectivity in the human brain

This study examines how CBD and THC affect striato-cortical connectivity in the human brain using fMRI, finding THC disrupts connectivity while CBD mitigates some effects and has mixed impacts when used alone.

CB1R Regulates Soluble Leptin Receptor Levels via CHOP, Contributing to Hepatic Leptin Resistance

This study shows that hepatic CB1R regulates soluble leptin receptor (sOb-R) levels through CHOP, contributing to leptin resistance in diet-induced obesity.

Testing The Role Of Δ9-Tetrahydrocannabinol During Adolescence As A Gateway Drug: Behavioural, Brain Imaging And Transcriptomic Studies

This study examines the effects of adolescent THC exposure on behavior, brain structure, and gene expression in rats, finding altered psychological and brain development but no clear support for the Gateway Hypothesis.

Cannabinoids modulate associative cerebellar learning via alterations in behavioral state

This study shows that CB1 receptor deletion affects cerebellar learning indirectly through altered behavioral state rather than direct synaptic plasticity effects.

Sex-specific maturational trajectory of endocannabinoid plasticity in the rat prefrontal cortex

This study identifies sex-specific developmental differences in endocannabinoid-mediated LTD in rat prefrontal cortex, showing distinct receptor usage and timing of eCB-LTD emergence between males and females.

Maternal exposure to the cannabinoid agonist WIN 55,12,2 during lactation induces lasting behavioral and synaptic alterations in the rat adult offspring of both sexes

Links between central CB1-receptor availability and peripheral endocannabinoids in patients with first episode psychosis

The paper investigates the relationship between central CB1-receptor availability and peripheral endocannabinoids in first-episode psychosis patients and healthy controls, finding dysregulated cross-talk between these systems.

Reelin deficiency contributes to long-term behavioral abnormalities induced by chronic adolescent exposure to Δ9-tetrahydrocannabinol in mice

This study shows that Reelin deficiency exacerbates long-term behavioral issues in mice exposed to THC during adolescence, including impaired social behavior and increased novelty seeking.

Effects of the cannabinoid receptor agonist CP-55,940 on incentive salience attribution

This study investigates how the cannabinoid agonist CP-55,940 affects sign-tracking and goal-tracking behaviors in rats, finding that it decreases sign-tracking and increases goal-tracking in a dose-dependent manner.

Perinatal THC Exposure via Lactation Induces Lasting Alterations to Social Behavior and Prefrontal Cortex Function in Rats at Adulthood

This study shows that THC exposure via lactation during early postnatal life leads to lasting behavioral and synaptic deficits in adult rats.

Long-Term Aberrations To Cerebellar Endocannabinoids Induced By Early-Life Stress

This study examines how early-life stress affects cerebellar endocannabinoid levels and behavior, revealing sex-specific differences and potential contributions to brain sexual differentiation.

Association of extent of cannabis use and psychotic like intoxication experiences in a multi-national sample of First Episode Psychosis patients and controls

This study examines whether cannabis use extent predicts psychotic-like and euphoric intoxication experiences in First Episode Psychosis patients and controls, finding a significant interaction between caseness and use frequency.

A new mutant mouse model lacking mitochondrial-associated CB1 receptor

The paper generates and characterizes a mutant mouse lacking mitochondrial-associated CB1 receptors to study their role in brain function and drug effects.

Single-cell Transcriptome Mapping Identifies Common and Cell-type Specific Genes Affected by Acute Delta9-tetrahydrocannabinol in Humans

This study identifies 294 genes affected by acute THC administration in human immune cells, including 69 common and 225 cell-type specific genes.

The effects of cannabidiol on cue- and stress-induced reinstatement of cocaine seeking behavior in mice are reverted by the CB1 receptor antagonist AM4113.

This study investigates cannabidiol's effects on cocaine seeking behavior in mice, finding it blocks cue-induced reinstatement but facilitates stress-induced reinstatement, with CB1 receptor involvement.

Vaporized cannabis extracts have reinforcing properties and support conditioned drug-seeking behavior in rats

This study shows that vaporized THC-rich cannabis extracts reinforce behavior and increase drug-seeking in rats, supporting their use as a preclinical model for cannabis research.

Reduced responsiveness of the reward system underlies tolerance to cannabis impairment in chronic users

This study shows chronic cannabis users show reduced reward system responsiveness to cannabis, leading to tolerance to its impairing effects.

Cell-type and endocannabinoid specific synapse connectivity in the adult nucleus accumbens core

The paper examines synaptic connectivity and plasticity in the adult mouse nucleus accumbens core, revealing pathway- and cell-type specific contributions of BLA, PFC, and vHipp inputs, and the role of endocannabinoid receptors.