Carcinogens and Genotoxicity Assessment

Assessment of variability in the human urinary nucleic acid adductome

This study assesses biological variability in the human urinary nucleic acid adductome, showing stable adduct profiles across time and identifying age and sex-related differences.

Direct CDK1 engagement underlies carbaryl-induced genotoxic cell cycle arrest

This study identifies CDK1 as a direct target of carbaryl, explaining its genotoxic effects and tissue-specific cytotoxicity in renal and cervical cells.

Identification of co-expressed gene sets for major molecular initiating events in rodent liver carcinogenesis using wild type and knock out rats

The paper identifies co-expressed gene sets linked to molecular initiating events in rodent liver carcinogenesis by comparing wild-type and knockout rats exposed to chemical activators.

From TD50 to Benchmark Dose in Nitrosamine Risk Assessment: Evidence from N-Nitrosotrimetazidine Carcinogenicity and TGR Mutation Data.

This paper evaluates the carcinogenic risk of N-Nitrosotrimetazidine using in vitro and in vivo studies, deriving a benchmark dose and tumor dose to refine acceptable intake limits.

Hazard characterization of Alternaria toxins - filling data gaps on in vitro genotoxicity.

This study assesses the in vitro genotoxicity of Alternaria toxins using OECD-aligned assays, finding mutagenicity and chromosomal damage for several toxins.

Cytotoxicity of Pelargonic Acid and Its Commercial Formulation Roundup NL (Glyphosate-Free Roundup)

This study assesses the cytotoxicity of pelargonic acid and its commercial formulation Roundup NL, finding that Roundup NL is more toxic than pelargonic acid and induces oxidative stress and protein damage.

The UV potentiated mutational signature of clinical stage G-quadruplex binder CX5461.

The paper investigates the mutational signature of CX5461, a photosensitiser, when combined with UVA light, showing increased SNV burden only in co-exposed cells.

Defining mutational signatures of lung cancer-associated carcinogens through in vitro exposure of human airway epithelial cells

This study uses in vitro exposure of human airway epithelial cells to genotoxic carcinogens to define mutational signatures associated with lung cancer.

Comprehensive Genotoxicity and Subchronic Oral Toxicity Evaluation of Kumamolisin from Bacillus sp. MN-32 for Human Use

The paper evaluates the genotoxicity and subchronic oral toxicity of Kumamolisin from Bacillus sp. MN-32, finding no genotoxicity and no safety concerns at the highest tested dose.

Genome-scale multi-organ analysis of mutagenic effects of ethanol and acetaldehyde in Sprague Dawley rats

This study examines the mutagenic effects of ethanol and acetaldehyde in rats, finding exposure-specific mutational signatures and suggesting inflammation or oxidative damage as key factors in alcohol-related cancers.

An evaluation of genotoxicity and 90-day repeated-dose toxicity in rats of a Dracocephalum moldavica powdered extract

This study evaluates the genotoxicity and 90-day repeated-dose toxicity of a Dracocephalum moldavica extract in rats, finding no mutagenic or clastogenic effects and no adverse effects at the highest dose.

Effects of Maleic Hydrazide on Germination, Radicle Growth and Mitotic Division of Trigonella foenum-graecum L. and Allium cepa L.

This paper investigates the effects of maleic hydrazide on germination, root growth, mitotic division, and chromosomal abnormalities in fenugreek and onion plants.

Sex and Alkyladenine DNA Glycosylase Expression are Key Susceptibility Factors for NDMA-induced Mutations, Toxicity, and Cancer

This study investigates sex differences in susceptibility to NDMA-induced mutations, toxicity, and cancer in mice, finding males are more prone to cancer while Aag overexpression increases toxicity, particularly in females.

Protocol for assessing DNA damage levels in vivo in rodent testicular germ cells in the Alkaline Comet Assay

This paper presents a protocol to measure DNA damage in rodent testicular germ cells using a modified alkaline comet assay, enabling assessment of genotoxic effects on spermatids and primary spermatocytes.

Investigating BPDE-induced embryonic toxicity employing hiPSC-based models

This study examines BPDE toxicity in hiPSCs and NPCs, revealing hiPSCs are more sensitive to BPDE with enhanced p53-mediated DNA damage response, and NBS patient cells show reduced apoptosis.

N-Acetyl-2-Aminofluorene (AAF): In vivo temporal expression patterns of growth cycle-dependent macromolecular binding constants KD are revealed by primary cultures of premalignant hepatocytes derived from a multi-cyclic hepatocarcinogenic feeding regimen

The paper investigates how macromolecular binding constants of AAF change during hepatocarcinogenesis using primary cultures of premalignant hepatocytes.

Systematic analysis of gut bacterial carcinogen metabolism and its functional consequences

The paper systematically analyzes gut bacterial metabolism of carcinogens and shows bidirectional interactions with host metabolism, highlighting the microbiome's role in tumorigenesis.

Error-corrected Duplex Sequencing enables direct detection and quantification of mutations in human TK6 cells with remarkable inter-laboratory consistency

This study demonstrates that error-corrected Duplex Sequencing reliably detects and quantifies mutations in human TK6 cells across different laboratories and time points.

Statistical notes on false positive and negative error rates in the evaluation of long-term carcinogenicity bioassays

The paper examines false positive and negative error rates in long-term carcinogenicity bioassays, focusing on their dependence on analysis methods and dose-response design.

Robust statistical evaluation of tumor incidences in long-term rodent carcinogenicity studies: the reformulated poly-k trend test

The paper reformulates the poly-k trend test to evaluate tumor incidences in rodent carcinogenicity studies by considering multiple dose-response shapes and statistical models.

Genotoxicity evaluation of levonorgestrel-releasing intrauterine system (LNG-IUS) in exfoliated cervical cells using the micronucleus (MN) test

This study evaluates the genotoxicity of LNG-IUS by analyzing micronuclei and other nuclear anomalies in cervical cells before and after insertion, finding no significant increase in micronuclei but increased cytotoxicity-related changes.