Carcinogens and Genotoxicity Assessment

Genotoxicity and 90-day oral toxicity of a monk fruit (Siraitia grosvenorii) mogroside preparation (>=95% mogrosides) produced by microbial fermentation

This study evaluates the genotoxicity and 90-day oral toxicity of a high-purity mogroside preparation from monk fruit, finding it non-mutagenic and non-clastogenic with no adverse effects at the highest tested dose.

Assessment of variability in the human urinary nucleic acid adductome

This study assesses biological variability in the human urinary nucleic acid adductome, showing stable adduct profiles across time and identifying age and sex-related differences.

Direct CDK1 engagement underlies carbaryl-induced genotoxic cell cycle arrest

This study identifies CDK1 as a direct target of carbaryl, explaining its genotoxic effects and tissue-specific cytotoxicity in renal and cervical cells.

Identification of co-expressed gene sets for major molecular initiating events in rodent liver carcinogenesis using wild type and knock out rats

The paper identifies co-expressed gene sets linked to molecular initiating events in rodent liver carcinogenesis by comparing wild-type and knockout rats exposed to chemical activators.

From TD50 to Benchmark Dose in Nitrosamine Risk Assessment: Evidence from N-Nitrosotrimetazidine Carcinogenicity and TGR Mutation Data.

This paper evaluates the carcinogenic risk of N-Nitrosotrimetazidine using in vitro and in vivo studies, deriving a benchmark dose and tumor dose to refine acceptable intake limits.

Hazard characterization of Alternaria toxins - filling data gaps on in vitro genotoxicity.

This study assesses the in vitro genotoxicity of Alternaria toxins using OECD-aligned assays, finding mutagenicity and chromosomal damage for several toxins.

Cytotoxicity of Pelargonic Acid and Its Commercial Formulation Roundup NL (Glyphosate-Free Roundup)

This study assesses the cytotoxicity of pelargonic acid and its commercial formulation Roundup NL, finding that Roundup NL is more toxic than pelargonic acid and induces oxidative stress and protein damage.

Molecular Dosimetry of DNA Adducts in Mice Exposed to Ethylene Oxide

This study quantifies DNA adduct formation in mice exposed to ethylene oxide, showing dose-dependent differences between two adducts and their implications for cancer risk assessment.

MutAIverse: An AI-Powered, Mechanism-backed Platform for Discovering Novel DNA Adducts and their precursor Genotoxins

MutAIverse detects known and novel DNA adducts and their precursor genotoxins using an AI-driven platform with mechanistic modeling and spectral mapping.

INVESTIGATION OF ETHYLENE OXIDE GENOTOXICITY DOSE-RESPONSE TO INFORM CANCER RISK ASSESSMENT

This study investigates the dose-response relationship of ethylene oxide-induced genetic damage in mice to assess its potential carcinogenicity through a mutagenic mechanism.

The UV potentiated mutational signature of clinical stage G-quadruplex binder CX5461.

The paper investigates the mutational signature of CX5461, a photosensitiser, when combined with UVA light, showing increased SNV burden only in co-exposed cells.

Mutagenic and carcinogenic potency determinations for NDMA support the cumulative dose assumption underpinning the less-than-lifetime Threshold of Toxicological Concern

The paper applies BMD modeling to NDMA datasets to support the cumulative dose assumption in the LTL-TTC framework, showing short-term assays can predict long-term carcinogenicity.

A METHOD TO CALIBRATE CHEMICAL AGNOSTIC QUANTITATIVE ADVERSE OUTCOME PATHWAYS ON MULTIPLE CHEMICAL DATA

This paper introduces a method to calibrate chemical-agnostic quantitative adverse outcome pathways (qAOPs) by separating chemical-specific heterogeneity from pathway effects, improving their reliability across multiple chemicals.

Persistent interferon signaling and clonal expansion mark early events in DNA methylation damage-induced liver cancer

This study identifies persistent interferon signaling and clonal expansion as early events in NDMA-induced liver cancer by analyzing molecular changes in mice.

Defining mutational signatures of lung cancer-associated carcinogens through in vitro exposure of human airway epithelial cells

This study uses in vitro exposure of human airway epithelial cells to genotoxic carcinogens to define mutational signatures associated with lung cancer.

Variability and uncertainty of data from genotoxicity Test Guidelines: What we know and why it matters.

This review analyzes variability and uncertainty in genotoxicity test guideline data, highlighting challenges in integrating non-animal methods into regulatory frameworks.

Multiple Pesticides and their Mixtures Tested for Genotoxicity in the Micronucleus Assays on Intestinal Caco-2 Cells

This study tests the genotoxicity of ten pesticides and their mixtures on Caco-2 cells using micronucleus assays, finding genotoxic effects in several individual pesticides and some mixtures.

Comprehensive Genotoxicity and Subchronic Oral Toxicity Evaluation of Kumamolisin from Bacillus sp. MN-32 for Human Use

The paper evaluates the genotoxicity and subchronic oral toxicity of Kumamolisin from Bacillus sp. MN-32, finding no genotoxicity and no safety concerns at the highest tested dose.

Evaluation of the genotoxic potential of dietary metabolites to support the renewal of an active substance under European Commission Regulation (EC) 1107/2009 -- fludioxonil case study

This paper evaluates the genotoxic potential of three dietary metabolites of fludioxonil using a tiered approach involving (Q)SAR, read across, and various in vitro and in vivo genotoxicity assays, concluding they pose no genotoxic concern.

DNA Content and DNA Damage in Raw and Heat-processed Foods

The paper assesses DNA content and damage in raw and heat-processed foods, finding significant DNA damage increases from cooking and potential cytotoxic effects in human cells.

An LC-MS/MS method for the quantification of tobacco-specific carcinogen protein adducts.

The paper develops an LC-MS/MS method to quantify NNAL-specific protein adducts in biological samples to assess tobacco exposure and estimate NNAL bioactivation.

Genome-scale multi-organ analysis of mutagenic effects of ethanol and acetaldehyde in Sprague Dawley rats

This study examines the mutagenic effects of ethanol and acetaldehyde in rats, finding exposure-specific mutational signatures and suggesting inflammation or oxidative damage as key factors in alcohol-related cancers.

A Comprehensive Toxicological Safety Evaluation of Anaerostipes caccae

This study evaluates the genotoxic and toxicological safety of Anaerostipes caccae CLB101 in rats, finding no adverse effects at doses up to 1000 mg/kg bw/day.

Alignment between Duplex Sequencing and transgenic rodent mutation assay data in the assessment of in vivo NDMA-induced mutagenesis

This study aligns Duplex Sequencing with transgenic rodent mutation assay data to assess in vivo NDMA-induced mutagenesis, finding dose-dependent mutation frequency increases and concordant benchmark dose estimates.

An evaluation of genotoxicity and 90-day repeated-dose toxicity in rats of a Dracocephalum moldavica powdered extract

This study evaluates the genotoxicity and 90-day repeated-dose toxicity of a Dracocephalum moldavica extract in rats, finding no mutagenic or clastogenic effects and no adverse effects at the highest dose.

Effects of Maleic Hydrazide on Germination, Radicle Growth and Mitotic Division of Trigonella foenum-graecum L. and Allium cepa L.

This paper investigates the effects of maleic hydrazide on germination, root growth, mitotic division, and chromosomal abnormalities in fenugreek and onion plants.

Sex and Alkyladenine DNA Glycosylase Expression are Key Susceptibility Factors for NDMA-induced Mutations, Toxicity, and Cancer

This study investigates sex differences in susceptibility to NDMA-induced mutations, toxicity, and cancer in mice, finding males are more prone to cancer while Aag overexpression increases toxicity, particularly in females.

Exposure to complex mixtures of urban sediments containing Tyre and Road Wear Particles (TRWPs) increases the germ-line mutation rate in Chironomus riparius

This study shows exposure to urban sediments containing TRWPs increases mutation rates in Chironomus riparius by 50%, with mutational profiles similar to those caused by Benzo[a]Pyrene.

Single-egg Comet Assay: a protocol to quantify DNA damage in aquatic dormant stages

The paper introduces a protocol to quantify DNA damage in individual dormant eggs using the comet assay, showing its effectiveness for assessing DNA integrity in sedimentary archives.

Neutral lipids restrict the mobility of broken DNA molecules during comet assays

This study shows that neutral lipids in the nucleoid restrict DNA migration in comet assays and may regulate DNA dynamics in the nucleus.