Muscle Physiology and Disorders

Differential Equation Modeling of Cell Population Dynamics in Skeletal Muscle Regeneration from Single-Cell Transcriptomic Data

The paper develops a non-linear ODE model of skeletal muscle regeneration using scRNA-seq data to capture cell population dynamics and regulatory interactions.

Protocol for muscle fiber type and cross-sectional areaanalysis in cryosections of whole lower mouse hindlimbs

This paper describes a protocol for analyzing muscle fiber type and cross-sectional area in cryosections of whole lower mouse hindlimbs using immunofluorescence and histochemistry.

Investigating the effects of prednisolone on behavior in mouse models of Duchenne muscular dystrophy

This study examines the effects of prednisolone on behavior in DMD mouse models, finding limited improvements in anxiety but no changes in social interaction or spatial learning.

Suppressing PDGFRβ Signaling Enhances Myocyte Fusion to Promote Skeletal Muscle Regeneration

This study identifies PDGFRβ signaling as a regulator of myocyte fusion and muscle regeneration, showing that its suppression enhances muscle repair and myofiber size.

Postsynaptic BMP signaling regulates myonuclear properties in Drosophila larval muscles

The paper identifies how BMP signaling regulates myonuclear properties at the Drosophila larval neuromuscular junction, affecting size, ploidy, and gene expression.

A novel ex vivo model of nerve-induced skeletal muscle contraction

The paper develops an ex vivo model of nerve-induced skeletal muscle contraction to study its endocrine and paracrine responses and effects on cell types.

Deregulation of multiple mechanisms shapes the onset of LAMA2-congenital muscular dystrophy

This study investigates the early molecular changes in LAMA2-CMD using a mouse model, identifying gene expression, cytoskeletal, and DNA repair defects at disease onset.

Structural variation in nebulin and its implications on phenotype and inheritance: establishing a dominant distal phenotype caused by large deletions

The paper identifies structural variants in the NEB gene across 35 families, showing large deletions cause dominant distal myopathy while recessive variants show no severity correlation.

A post-mitotic in vitro murine as a model of muscle damage and repair

The paper develops an in vitro murine model of sarcopenia by differentiating C2C12 myoblasts, showing similarity to human myotubes and recapitulating sarcopenia features under nutrient deprivation and dexamethasone treatment.

Network-based modelling reveals cell-type enriched patterns of non-coding RNA regulation during human skeletal muscle remodelling

The paper identifies ncRNA genes regulated during skeletal muscle hypertrophy in 144 individuals using transcriptomic analysis and network modelling.

Changes in Myofibril Size, Shape, and Network Connectivity in Aging Muscle

This study examines changes in myofibril size, shape, and connectivity in aging muscle across mice and humans, finding increased connectivity and variable size/shape changes depending on muscle type.

Submaximal eccentric resistance training increases serial sarcomere number and improves dynamic muscle performance in old rats

Branched actin polymerization drives invasive protrusion formation to promote myoblast fusion during skeletal muscle regeneration

This study identifies branched actin polymerization as essential for myoblast fusion during skeletal muscle regeneration, showing its role in forming invasive protrusions for fusion.

Differential inclusion of NEB exons 143 and 144 provides insight into NEB-related myopathy variant interpretation and disease manifestation

The paper reports two patients with NEB-related congenital myopathy and describes how differential inclusion of NEB exons 143 and 144 affects disease manifestation and MRI patterns.

The androgen receptor in mesenchymal progenitors regulates skeletal muscle mass via Igf1 expression in male mice.

This study shows that androgen receptor in mesenchymal progenitors regulates skeletal muscle mass via Igf1 expression in male mice, with effects seen in adult but not young or aged mice.

The Drosophila myogenic inhibitor Him gene is essential for adult muscle function and muscle stem cell maintenance

This paper identifies Him as a marker for Drosophila adult muscle stem cells and shows its role in maintaining muscle stem cell numbers and flight ability during aging.

Differential Effectiveness of Poloxamer 188 in Dystrophic Cardiomyopathy Reveals Complex Pathophysiology.

This study evaluates the effectiveness of poloxamer 188 in protecting against myocardial damage in dystrophic mouse models, revealing sex and genotype-specific responses.

Myosin ATPase inhibition fails to rescue the metabolically dysregulated proteome of nebulin-deficient muscle

This study tests Mavacamten's ability to rescue metabolic dysregulation in nebulin-deficient muscle, finding it effective in vitro but ineffective in vivo for reversing the proteome changes.

Expert Panel Curation of 31 Genes in Relation to Limb Girdle Muscular Dystrophy

The paper curates 31 genes associated with limb girdle muscular dystrophy (LGMD) using an expert panel and clinical validity framework, identifying 35 gene-disease relationships with varying levels of evidence.

In dystrophic mdx hindlimb muscles where fibrosis is limited versican haploinsufficiency transiently improves contractile function without decreasing inflammation

This study shows that reducing versican in dystrophic mdx hindlimb muscles improves contractile function in juvenile mice without reducing inflammation, but these benefits are lost in adults.

A mechanically regulated liquid-liquid phase separation of the transcriptional regulator Tono instructs muscle development

This study identifies Tono as a mechanically responsive transcriptional regulator that controls sarcomere maturation through liquid-liquid phase separation in Drosophila muscle development.

Quantifying anti-DUX4 therapy for facioscapulohumeral muscular dystrophy

This paper develops a mathematical model to evaluate anti-DUX4 therapies for FSHD, finding that reducing DUX4 diffusion is more effective than reducing apoptosis, and that combining strategies yields better results.

Development of a Novel Japanese Eel Myoblast Cell Line for Application in Cultured Meat Production

This paper isolates and characterizes a Japanese eel myoblast cell line, JEM1129, which shows robust myogenic differentiation and potential for cultured meat production.

Age-related differences in the loss and recovery of serial sarcomere number following disuse atrophy in rats

This study compares age-related differences in serial sarcomere number recovery and muscle function after disuse in young and old rats, finding older rats recover longitudinal morphology better than parallel morphology.

Integrating in silico predictions with an engineered tissue assay identifies Perlecan as an age-perturbed re-quiescence cue for muscle stem cells

The paper identifies Perlecan as a factor that influences muscle stem cell re-quiescence, showing its age-related changes and therapeutic potential.

A novel c.515delC HSPB8-multisystem proteinopathy associated with inclusion body myopathy with cardiomyopathy

The paper reports a novel HSPB8 mutation causing multisystem proteinopathy with inclusion body myopathy and cardiomyopathy, highlighting sex differences in disease severity and onset.

Mature adipocytes inhibit differentiation of myogenic cells but stimulate proliferation of fibro-adipogenic precursors derived from trout muscle in vitro.

This study shows that trout adipocytes promote fibro-adipogenic precursor proliferation while inhibiting myogenic cell differentiation in vitro.

Moderate-term dimethyl fumarate treatment reduces pathology of dystrophic skeletal and cardiac muscle in a mouse model

This study shows that moderate-term dimethyl fumarate treatment reduces dystrophic muscle pathology in a mouse model of Duchenne muscular dystrophy, with anti-inflammatory, anti-fibrotic, and anti-lipogenic effects.

Spatial and mechanical environments regulate the heterogeneity of myonuclei

The paper investigates how spatial and mechanical environments influence myonucleus heterogeneity in muscle development, finding that 2D cultures and paralyzed muscles lose regionalized molecular signatures and cellular diversity.

Gene expression differences associated with intrinsic hindfoot muscle loss in the jerboa, Jaculus jaculus

The paper identifies gene expression differences in jerboa hindfoot muscle loss by comparing intra- and inter-species muscle data, revealing pathways linked to muscle atrophy and potential parallels with human muscle disorders.