Muscle Physiology and Disorders

Regionalisation of muscle nucleus heterogeneity in foetal skeletal muscle

The paper identifies transcriptionally distinct muscle nuclei in fetal chicken limb muscles, showing tip and central domain identities and signaling roles in muscle development.

LEUTX mediates amplification of DUX4 signaling and aberrant myotube differentiation in facioscapulohumeral muscular dystrophy

This study identifies LEUTX as a key amplifier of DUX4 signaling in FSHD, showing its role in disrupting myotube differentiation and promoting aberrant gene expression.

IFNγ-CXCL9-CXCR3 axis links T cell recruitment to skeletal muscle remodelling in human physical frailty

This paper identifies an IFNγ-CXCL9-CXCR3 axis linking T cell recruitment to skeletal muscle remodelling in human physical frailty, showing its association with fibrosis and potential therapeutic targets.

Distinct patterns of skeletal muscle wasting and mitochondrial changes following hypoxia and inflammation: associations with physiological phenotype

This study examines how hypoxia and inflammation affect skeletal muscle mitochondrial function and protein turnover in different muscle types, finding muscle-specific responses and physiological variability.

Phosphorylation of CARM1 at Ser572 preserves muscle stem cell self-renewal by restricting premature myogenic commitment

This study shows that phosphorylation of CARM1 at Ser572 is essential for maintaining muscle stem cell self-renewal by preventing premature myogenic commitment.

Spatial transcriptomics maps region and isoform specific brain alterations in mdx and mdx4cv models of Duchenne muscular dystrophy

This study uses spatial transcriptomics to compare gene expression changes in brain regions of mdx and mdx4cv DMD mouse models, revealing distinct patterns linked to dystrophin isoform loss.

The interferon-gamma response pathway is a targetable driver of FSHD muscular dystrophy progression

This study identifies the IFN-gamma pathway as a therapeutic target for FSHD by showing its role in driving inflammation and disease progression.

Cross-species transcriptomic atlas of X-linked Myotubular Myopathy identifies unique, treatment responsive myofiber populations

This study identifies unique myofiber populations in XLMTM using transcriptomics and shows they respond to therapeutic interventions across species.

N-terminal truncation diversifies USP18 function during early myogenesis

This study shows that the N-terminal truncation of USP18 generates a short isoform (SF) with distinct functions in muscle differentiation compared to the long isoform (LF).

NAD+ limitation and α-ketoglutarate depletion define cancer induced muscle atrophy

This study identifies NAD+ limitation and α-ketoglutarate depletion as mechanisms by which pancreatic cancer cells induce muscle atrophy through metabolic rewiring and redox imbalance.

Matrix Metalloproteinase Response to Acute Resistance Exercise is Altered in Osteoarthritic Adults with Increased Muscle Collagen and PDGFRα+ Mesenchymal Cells

This study examines how MMPs respond to resistance exercise in knee OA patients, finding impaired ECM remodeling and altered PDGFR+ mesenchymal and satellite cell dynamics.

Continuous Large Maf Activity Maintains Fast Myofiber Identity and Multicellular Homeostasis in Adult Skeletal Muscle

Plakoglobin supports length-dependent force generation and cardiac resistance to fasting

This study shows plakoglobin supports force generation in skeletal muscle and protects cardiac muscle from fasting-induced atrophy by maintaining anabolic signaling and sarcolemmal complexes.

Integrative Multi-omics Analysis of the Human Skeletal Muscle Response to Endurance or Resistance Exercise: Findings from the Molecular Transducers of Physical Activity Consortium (MoTrPAC)

In 174 sedentary adults, resistance exercise changed more muscle molecular features than endurance exercise across omes and time points; network analysis nominates MEF2A and NFIC as regulatory hubs.

Contraction type dependence of serial sarcomere addition following resistance training

This study examines how different contraction types during resistance training affect serial sarcomere addition in rats, finding that isometric and eccentric training drive sarcomerogenesis more than concentric training.

The annexin A1 mimetic peptide Ac2-26 promotes inflammation-resolution and stimulates skeletal muscle regeneration in the mdx mouse model of Duchenne muscular dystrophy

This study shows that the ANXA1 mimetic peptide Ac2-26 reduces inflammation and improves skeletal muscle regeneration in mdx mice, offering a potential steroid-sparing therapy for DMD.

Transient 5-azacytidine exposure elicits persistent myogenic-like transcriptional remodeling in zebrafish fibroblasts: implications for cultivated seafood

The paper shows that zebrafish fibroblasts can undergo persistent myogenic-like transcriptional changes after transient 5-azacytidine exposure, suggesting potential for cultivated seafood applications.

Aging remodels the human muscle secretome, impairing stem cell via sphingolipid metabolism

This study identifies age-related changes in the muscle secretome that impair stem cell function through sphingolipid metabolism alterations.

Integrative Multi-Omics Analysis Reveals Molecular Signatures of Age-Related Decline in Vervet Leg Skeletal Muscle

The paper identifies a molecular signature of age-related decline in vervet monkey skeletal muscle through multi-omics analysis, highlighting miRNA and epigenetic changes associated with sarcopenia.

The androgen receptor polyglutamine tract sets the transcriptional balance between muscle growth and atrophy

This study identifies how the polyglutamine tract in the androgen receptor regulates muscle growth and atrophy by altering transcriptional activity and chromatin binding.

Snurportin-1 maintains muscle niche integrity and myogenic progenitor homeostasis

This study identifies Snurportin-1 as critical for skeletal muscle homeostasis by linking RNA processing to extracellular niche integrity and myogenic progenitor maintenance using a zebrafish model.

Fibro-adipogenic Progenitor and Macrophage Remodeling of the Aging Skeletal Muscle Niche During Exercise-Induced Hypertrophy

This study examines how exercise-induced hypertrophy in older adults alters fibro-adipogenic progenitors (FAPs) and macrophages in skeletal muscle, revealing phenotypic shifts and interactions that support muscle growth.

DEPP1 connects nutrient and oxygen availability to maintenance of muscle mass

This study identifies DEPP1 as a new atrogene that mediates muscle loss under nutrient or oxygen limitation by linking FoxO and HIF pathways.

Spatial Transcriptomics Identifies Muscle Inflammation Susceptibility as a Distinct Periarticular Skeletal Muscle Phenotype in End-Stage Knee Osteoarthritis

The Orai3 channel and AHNAK2 scaffold protein promote the activation of primary human muscle stem cells in vitro

This study identifies Orai3 and AHNAK2 as key regulators of human muscle stem cell activation, showing they act through distinct pathways to promote myoblast differentiation and RC activation.

Disrupted FAP-satellite cell communication contribute to maladaptive muscle remodeling in older women

This study identifies altered FAP-satellite cell communication and impaired myogenic function in older women during recovery from disuse atrophy, contributing to poor muscle remodeling.

Exercise preconditioning confers skeletal muscle myometaplasticity

The paper shows that exercise preconditioning enhances skeletal muscle hypertrophy through epigenetic and metabolic changes, specifically involving Smox and Wnt signaling.

Multiomics Characterization Identifies S1P-secreting USSHigh Skeletal Muscle Stem Cells as Essential Drivers of Niche Remodeling and Muscle Regeneration

The paper identifies a senescent-like muscle stem cell subpopulation that drives muscle regeneration through secretory activity and cell communication.

Transcriptome analysis reveals CCND2 promotes myogenic differentiation of pig skeletal muscle

The paper identifies differentially expressed genes and gene modules in pig skeletal muscle and shows CCND2 promotes myogenic differentiation.

Gut microbiota-dependent phenylpropanoic acid derivatives reduced in cancer cachexia protect against myotube atrophy

The paper identifies gut microbiota-derived metabolites that protect against muscle atrophy in cancer cachexia by restoring amino acid homeostasis through the serine biosynthesis pathway.