Muscle Physiology and Disorders

RNAi screen in Tribolium reveals involvement of F-BAR proteins in myoblast fusion and visceral muscle morphogenesis in insects

The paper identifies F-BAR proteins as critical for myoblast fusion and midgut morphogenesis in insects through RNAi screening in Tribolium.

Dissection of the cellular function of the ZBED6 transcription factor in mouse myoblast cells using gene editing, RNAseq and proteomics

This study investigates ZBED6's role in mouse myoblasts using gene editing, RNAseq, and proteomics, showing ZBED6 regulates IGF2 through a specific binding site, affecting mitochondrial activity and myogenesis.

Consecutive signaling pathways are activated in progression of Duchenne muscular dystrophy in C. elegans

The paper analyzes dystrophin-deficient muscle transcriptomes in C. elegans to identify signaling pathway changes during Duchenne muscular dystrophy progression and develops a screening method for genetic partners of dystrophin.

Quantitative proteomics reveals key roles for post-transcriptional gene regulation in the molecular pathology of FSHD

The paper quantifies proteomic changes in DUX4-expressing cells, revealing post-transcriptional dysregulation in FSHD pathology.

The LIM-Only Protein FHL2 is Involved in Autophagy to Regulate the Development of Skeletal Muscle

This study shows that FHL2 interacts with LC3- to regulate autophagy in muscle differentiation, affecting myogenesis and cell survival.

High-throughput data-driven analysis of myofiber composition reveals muscle-specific disease and age-associated patterns

The paper develops a high-throughput method to analyze myofiber composition and identifies age- and muscle-specific patterns and disease-related changes.

Plum is a novel regulator of synaptic function and muscle size in D. melanogaster

The paper identifies Plum as a regulator of neuromuscular function and muscle size in Drosophila by modulating Myoglianin activity.

L-tyrosine supplementation is not therapeutic for skeletal muscle dysfunction in zebrafish and mouse models of dominant skeletal muscle α-actin nemaline myopathy.

This study shows L-tyrosine supplementation does not improve skeletal muscle function in zebrafish and mouse models of nemaline myopathy caused by ACTA1 mutations.

Intracellular calcium dysregulation precedes muscle decline in C. elegans modeling Duchenne muscular dystrophy

This study shows that sarcoplasmic calcium dysregulation occurs before structural muscle damage in C. elegans modeling Duchenne muscular dystrophy and that increased activity can improve some muscular parameters but not longevity.

Rbfox splicing factors maintain skeletal muscle mass by regulating calpain3 and proteostasis

This study shows Rbfox1/2 regulate proteostasis in skeletal muscle by controlling calpain3 and autophagy, preventing muscle mass loss in adult mice.

Systematic transcriptomics reveals a biphasic mode of sarcomere morphogenesis in flight muscles regulated by Spalt

The paper identifies a biphasic mode of sarcomere development in Drosophila flight muscles, regulated by Spalt major, with distinct phases of assembly and maturation.

Transcriptional profiling reveals extraordinary diversity among skeletal muscle tissues

The paper profiles transcriptional diversity across skeletal, smooth, and cardiac muscles in mice and rats, revealing extensive gene expression differences and disease associations.

Tissue-specific activities of the Fat1 cadherin cooperate to control neuromuscular morphogenesis

This study shows Fat1 cadherin has distinct roles in muscle progenitors, mesenchymal cells, and motor neurons to coordinate neuromuscular morphogenesis during development.

Lipid utilization in skeletal muscle cells is modulated in vitro and in vivo by specific miRNAs

The paper identifies miR-27a-3p and miR-142-3p as key regulators of lipid utilization in skeletal muscle by analyzing single-cell mRNA and miRNA signatures.

New insights in Tibial muscular dystrophy revealed by protein-protein interaction networks

The paper investigates Tibial muscular dystrophy using protein-protein interaction networks to identify potential disease-related interactions.

Abelson tyrosine-protein kinase 2 Regulates Myoblast Proliferation and Controls Muscle Fiber Length

This paper shows that Abl2 regulates myoblast proliferation and myofiber length, leading to longer fibers and reduced stamina in mutant mice.

Single-cell quantitative analysis of skeletal muscle cell population dynamicsduring regeneration and ageing

This study uses single-cell mass cytometry to analyze skeletal muscle cell dynamics during regeneration and ageing, revealing population heterogeneity and responses to perturbations.

Identification and Functional Characterization of Muscle SatelliteCells in Drosophila

The paper identifies and characterizes muscle satellite cells in Drosophila, showing they function similarly to vertebrate satellite cells in muscle regeneration.

Myotome adaptability confers developmental robustness to somitic myogenesis in response to fibre number alteration.

The paper shows that zebrafish muscle stem cells adjust their numbers and behavior in response to changes in fibre number, maintaining muscle size through homeostatic mechanisms.

Myomerger Induces Fusion Of Non-Fusogenic Cells And Is Required For Myoblast Fusion

The paper identifies myomerger as a critical protein required for myoblast fusion and demonstrates its role in inducing fusogenicity in non-fusogenic cells.

Epigenetic Regulators Modulate Muscle Damage In Duchenne Muscular Dystrophy Model

This study investigates the role of epigenetic regulators in Duchenne muscular dystrophy by testing HAT and HDAC modulation in zebrafish models, finding that CBP/p300 and HDAC inhibitors prevent early muscle damage independently of known mechanisms.

P53 is not necessary for DUX4 pathology

This study shows that DUX4 causes cell death and pathology in both in vitro and mouse models independent of p53, challenging the idea that p53 is central to DUX4's pathogenicity.