Microtubule and mitosis dynamics

Molecular basis for the assembly of the dynein transport machinery on microtubules

This study reveals structural insights into microtubule-mediated dynein-dynactin-adaptor complex assembly using cryo-electron microscopy.

Native molecular architectures of centrosomes in C. elegans embryos

The paper uses cryo-electron tomography to visualize centrosomes in C. elegans embryos, revealing structural features and differences in microtubule organization during the cell cycle.

Centromeric localization of KNL2 and CENP-C proteins in plants depends on their centromere-targeting domain and DNA-binding regions

AuroraB-kinase methylation by SETD6 regulates cytokinesis and protects cells from chromosomal instability

This study shows that SETD6 methylates Aurora-B kinase, regulating cytokinesis and preventing chromosomal instability, with implications for cancer.

The Chromosome Periphery is an Essential Compartment of Oocyte Chromosomes

This study investigates the role of the chromosome periphery in oocyte meiosis, showing its impact on chromosome structure and meiotic progression in human and mouse oocytes.

KIF18A in HCC Metastasis: Dual Role in Anoikis Resistance and Chromosome Instability

The paper investigates KIF18A's role in HCC metastasis, showing it promotes survival and metastasis through CIN and anoikis resistance mechanisms.

Ki-67 and CDK1 Control the Dynamic Association of Nuclear Lipids with Mitotic Chromosomes

This study shows Ki-67 and CDK1 regulate nuclear lipid distribution around chromosomes during mitosis, ensuring proper chromosome segregation and genome integrity.

Molecular basis for condensin enrichment at pericentromeres

This study identifies a molecular mechanism by which condensin is recruited to pericentromeres through a conserved interaction between Ycg1 and Sgo1, ensuring proper chromosome segregation.

Dual roles of IQCG, a novel microtubule nucleation factor rapidly evolving in humans

The paper identifies IQCG as a novel microtubule nucleation factor with dual roles in centrosomal organization and mitotic spindle formation, showing accelerated evolution in humans.

ARHGEF17/TEM4 regulates the cell cycle through control of G1 progression

This study shows TEM4 regulates the cell cycle by controlling G1 progression through modulation of p21waf1/cip1 and cyclin B levels.

Mitochondrial Signatures Shape Phenotype Switching and Apoptosis in Response to PLK1 and RSK Inhibitors in Melanoma

The paper identifies mitochondrial protein signatures that determine sensitivity to PLK1 inhibitors in melanoma, showing that mitochondrial DNA depletion and ABCD1 silencing enhance sensitivity and reduce pro-inflammatory responses.

Isolation and manipulation of meiotic spindles from mouse oocytes reveals migration regulated by pulling force during asymmetric division

This study isolates meiotic spindles from mouse oocytes to investigate migration forces during asymmetric division, finding a net tensile force of ~680 pN.

Model for chromosome congression based on motor proteins in microtubule overlaps

The paper introduces a physical model to explain chromosome congression by analyzing forces from motor proteins and passive crosslinkers in the mitotic spindle.

A novel SUN1-ALLAN complex coordinates segregation of the bipartite MTOC across the nuclear envelope during rapid closed mitosis in Plasmodium

This study identifies the SUN1-ALLAN complex as critical for coordinating nuclear envelope remodeling and bipartite MTOC segregation during rapid mitosis in Plasmodium male gametogenesis.

Secretory trafficking maintains the organelle band for spindle separation during Arabidopsis meiosis

The paper identifies PELE as a protein that balances vacuolar and secretory trafficking to maintain the organelle band for spindle separation during Arabidopsis meiosis.

Mechanisms of axoneme and centriole elimination in Naegleria gruberi

This study identifies mechanisms by which Naegleria gruberi eliminates axonemes and centrioles during life cycle reversion, revealing lysosomal and proteasome-dependent pathways and extracellular shedding.

Self-organized spatial targeting of contractile actomyosin rings for synthetic cell division

This study demonstrates the self-organized spatial targeting of contractile actomyosin rings in GUVs using the MinDE system, leading to membrane deformation and symmetry breaking.

Modulation of Microtubule Dynamics by Monovalent Ions

This study examines how four monovalent ions affect microtubule dynamics in vitro, revealing distinct effects with Na+ destabilizing and Ac- stabilizing microtubules.

Selective regulation of kinesin-5 function by β-tubulin carboxy-terminal tails

This study identifies a molecular mechanism by which β-tubulin tails selectively regulate kinesin-5 motors, ensuring proper mitotic spindle function in budding yeast.

Processivity of the monomeric KLP-6 kinesin and a Brownian ratchet model with symmetric potentials

This study shows that the monomeric kinesin-3 motor KLP-6 moves processively along microtubules via its tail domain, explained by a Brownian ratchet model involving conformational changes rather than asymmetric potentials.

A floor-field model of tau-taxol competition explains tau envelope dynamics on taxol-stabilized microtubules

This study uses a floor-field model to show that tau-taxol competition on microtubules explains tau envelope formation and stability without requiring tau-tau interactions.

Identification of the Polo-like kinase substrate required for homologous synapsis in C. elegans

This study identifies that Polo-like kinases phosphorylate SYP-5 and SYP-6 to mediate SC-axis interaction and homolog pairing in C. elegans.

Centromere-proximal crossovers disrupt proper homologous chromosome disjunction during meiosis

This study shows that increased centromere-proximal crossovers cause meiotic nondisjunction and biorientation in S. pombe, supporting the entanglement model and highlighting mechanisms of aneuploidy.

Molecular interplay between HURP and Kif18A in mitotic spindle regulation

This study investigates how HURP regulates Kif18A motility and microtubule dynamics during mitosis using single-molecule imaging and Cryo-EM.

HURP facilitates spindle assembly by stabilizing microtubules and working synergistically with TPX2

This study shows HURP stabilizes microtubules and works with TPX2 to promote branching microtubule nucleation during spindle assembly in Xenopus egg extract.

Active fluctuations of axoneme oscillations scale with number of dynein motors

The paper quantifies phase fluctuations in axonemes after dynein motor removal, showing increased oscillation precision with motor number and distinct roles for inner and outer arm dyneins.

Structuring Role of Tau-Tubulin Co-Condensates in Early Microtubule Organization

The paper investigates how tau-tubulin co-condensates organize microtubules through dynamic clustering and tubulin enrichment, revealing their role in network formation and adaptation.

VezA/vezatin facilitates proper assembly of the dynactin complex in vivo

This study identifies VezA/vezatin as a factor essential for dynactin complex assembly in Aspergillus nidulans, highlighting its role in connecting Arp1 mini-filament and pointed-end sub-complex.

Molecular Insights into AGS3's Role in Spindle Orientation: A Biochemical Perspective

This study investigates AGS3's role in spindle orientation, showing it differs from LGN due to structural differences and regulatory interactions with Insc.

Molecular details and phospho-regulation of the CENP-T-Mis12 complex interaction during mitosis in DT40 cells

The paper investigates the molecular details and phospho-regulation of the CENP-T-Mis12 complex interaction during mitosis in DT40 cells, showing dual phosphorylation ensures robust interaction and proper mitotic progression.