Microtubule and mitosis dynamics

The paper identifies a non-autonomous role for somatic cells in maintaining germline incomplete cytokinesis through FGF signaling in Drosophila.

This study identifies the molecular mechanisms that distinguish meiotic cohesin paralogs from their mitotic counterparts in Schizosaccharomyces pombe, showing why mitotic proteins cannot fulfill meiotic functions.

This study identifies CAMSAP2 condensates as a γ-TuRC-independent mechanism for non-centrosomal microtubule nucleation through phase separation and tubulin organization.

This study identifies a critical segment in SKA3's C-terminus that mediates interaction between SKA and NDC80 complexes, essential for metaphase-to-anaphase transition in mitosis.

This study shows that kinetochore proteins in Drosophila and human cells support Golgi assembly and microtubule dynamics in quiescent neural stem cells.

The paper identifies the SKA complex as a mitotic vulnerability in chromosomally unstable cancers, showing its selective impact on these cells through prolonged mitosis.

The paper measures ATP gradients in motor-microtubule assemblies and shows they are sustained by energy consumption, with implications for cytoskeletal organization.

This study identifies structural switches in tubulin that Taxol exploits to stabilize microtubules by reverting them to a pre-hydrolysis state.

This study shows that KATANIN p60 is essential for forming complete preprophase bands in maize, which is necessary for proper division positioning of subsidiary mother cells.

The paper investigates how the P3018S mutation in dynein affects its function, revealing that the trailing motor in multi-dynein assemblies dictates ensemble velocity.

This study identifies Profilin 1 as a safeguard against genome doubling and polyploidy in cancer by showing its role in maintaining cell cycle fidelity and preventing therapeutic resistance.

This study identifies a non-centrosomal microtubule-organizing center (ncMTOC) in Drosophila oocytes that is essential for nuclear positioning during early oogenesis.

This study identifies a nucleotide-triggered mechanism that stabilizes the G-interface and enables NC-interface assembly in septins, revealing unidirectional allosteric signaling during filament formation.

This study shows SLD5/GINS4 regulates dynein-dependent centrosome maturation and identifies it as a potential therapeutic target in replication-driven cancers.

This study shows that age-related changes in cohesion strength in oocytes lead to different types of chromosome segregation errors in eggs from young and old females.

This paper identifies GSK3-dependent phosphorylation of SEPT9 as a mechanism regulating its partitioning between actin and microtubules, affecting neuronal polarization.

This study shows CAMSAP2 and Kif2a regulate midzone microtubule dynamics and cell abscission in human cells through their opposing roles in microtubule organization.

The paper identifies genetic suppressors of centrosome depletion sensitivity, revealing the AURKA-TPX2 axis as a critical pathway for spindle assembly under centrosome depletion.

This study models a MOPD II-associated Pericentrin variant in Drosophila, showing it disrupts dimerization and pericentriolar material recruitment, leading to developmental and cellular defects.

This study designs synthetic biomolecular condensates that control microtubule assembly through tunable material properties and interfacial rheology.

The paper shows that microtubule asters in C. elegans use a cellular analog of geometric optics to position pronuclei during cell division, with surface-anchored motors and dynamic terminator curves governing this process.

This paper develops a genetically encoded tool to manipulate microtubule bundling in cells and shows that bundling directly stabilizes microtubules and influences cellular processes.

This study identifies TACC3 as a vulnerability in MYC-overexpressing triple-negative breast cancers, showing that its inhibition induces cytotoxicity and inflammatory responses.

This study determines cryo-EM structures of dynein-dynactin complexes with five adaptors, revealing shared activation mechanisms and adaptor-specific structural features.

This study shows NPP-21/TPR is required for stronger spindle checkpoint in C. elegans germline cells through mechanisms involving PCH-2 concentration and Mad2 localization.

This study identifies Wdr62 as a regulator of acentrosomal microtubule organization in Drosophila oogenesis and shows its functional cooperation with Patronin and Katanin 80.

This study identifies the molecular mechanisms by which Ndc80 and Ska complexes cooperate to form stable kinetochore-microtubule attachments through structural and functional analyses.

This study identifies multiple pathways in yeast that coordinate meiosis I chromosome segregation with the meiotic spindle cycle through genetic screening and functional analysis.