Wnt/β-catenin signaling in development and cancer

The paper identifies spatial and temporal regulation of Wnt signaling pathway members in butterfly eyespot development and shows their functional roles.

The paper shows that WntA and Frizzled2 form a signaling axis that instructs butterfly color patterning, with Fz2 acting as a morphogen receptor and other Frizzleds having distinct roles in wing development.

The paper studies Wnt ligand dynamics in C. elegans embryos to show how diffusion enables long-range signaling and cell polarity.

The paper examines single-cell Wnt signaling responses in human embryonic stem cells and finds that Wnt target gene activation varies among cells, showing uncoupling in gene expression patterns.

The paper shows that β-catenin binds different genomic loci over time, leading to cell-type specific chromatin responses termed plastic or elastic during Wnt signaling.

The paper introduces a modified CUT&RUN protocol, LoV-U, to reliably profile β-catenin binding and identifies its tissue-specific target genes in human and mouse cells.

This paper models a human FZD2 variant in mice, identifies limb and cleft palate phenotypes, and shows DKK1 inhibition can normalize limb defects.

This study identifies Cachd1 as a novel Wnt receptor-interacting protein essential for left-right neuronal asymmetry in zebrafish.

The paper demonstrates that Wnt5b/Ror2 complexes are transported via cytonemes to trigger Wnt/PCP signaling in zebrafish gastrulation, independent of receptor expression.

This study identifies FOXQ1 as a bimodal activator of Wnt/β-catenin signalling, functioning through TCF/LEF factors and independent mechanisms.

This study shows Groucho and LSY-22/AES repress Wnt target genes in C. elegans asymmetric cell divisions, with Groucho regulating POP-1/TCF expression and LSY-22/AES acting as a TCF repressor.

The paper shows SOX transcription factors mediate WNT/{beta}-catenin transcription independently of TCFs during hPSC differentiation into DE and NMPs.

The paper identifies the spatial organisation and regulatory mechanisms of epithelial lineages at the gastroesophageal junction using multi-omics approaches and shows that Wnt microenvironments maintain homeostasis without lineage plasticity.

The paper constructs a Waddington landscape model to predict cell fate decisions during C. elegans mesoendoderm differentiation based on Wnt dynamics and mutant penetrance data.

The paper investigates how a COG4 mutation causes SWS by disrupting non-canonical Wnt signaling in zebrafish and fibroblasts, leading to developmental defects.

This study identifies FTO's role in regulating multiple WNT signaling pathways, revealing its impact on canonical and noncanonical WNT signaling through RNA demethylation and DKK1 upregulation.

The paper investigates how an oncogenic mutation in β-catenin affects the Wnt pathway by altering phosphorylation and degradation mechanisms.

This study shows Arf6 is required downstream of Armadillo/β-catenin stabilization for high-level Wingless signaling in Drosophila wing development.

The paper screens a chemical library to identify environmental chemicals that modulate Wnt signaling, finding diethanolamine as a stimulator with potential for prenatal exposure.

The paper shows that Sox2 levels determine how WNT signaling affects epiblast progenitors, influencing pluripotency and mesodermal differentiation through changes in chromatin occupancy and regulatory element selection.

This study investigates caspase cleavage of Drosophila Sgg-PD proteoforms, revealing their role in cytoskeletal and cell junction regulation and unexpected retention of cleaved N-terminal domains.

This study identifies a feedforward circuit between WSB1 and c-Myc that promotes cancer development through β-catenin signaling, suggesting a potential therapeutic target.

This study identifies HAS-7, an astacin proteinase, as a Wnt processing factor that regulates head formation in Hydra by controlling Wnt ligand activity and axis patterning.

The paper identifies Wnt/PCP-activated Lgr5+ intestinal stem cells that directly differentiate into enteroendocrine or Paneth cells, challenging previous models of multipotency.

This study uses genome engineering to fluorescently tag wild-type and mutant beta-catenin alleles in colorectal cancer cells, revealing distinct biophysical properties and showing how Wnt signaling modulates wild-type behavior to resemble the mutant form.

This study investigates whether Wnt ligands are required for planar cell polarity in Drosophila wing and notum, finding no evidence supporting their role.

This study shows that β-catenin signaling regulates chondrocyte-to-osteoblast transformation during fracture healing and identifies its role in stem cell generation for repair.

This paper shows that APC-/- tumors in Drosophila disrupt EGF feedback by inducing Rho in both neighboring and tumor cells, leading to chronic EGF signaling and cancerous overgrowth.

This study shows androgen signaling modulates canonical Wnt activity in prostate basal stem cells, maintaining their multipotency by suppressing Wnt-driven differentiation.

The paper identifies PI4K2β as a PAR-1 substrate that inhibits both canonical and non-canonical Wnt pathways, contrasting with PI4K2 which only affects canonical signalling.