Endometriosis Research and Treatment

Multi-ancestry genome-wide association study of endometriosis and its clinical manifestations in ~1.4 million women: translating gene discovery into pathogenic mechanisms and therapeutic targets

This study identifies 80 genome-wide significant associations for endometriosis and adenomyosis in 1.4 million women, uncovering novel loci and pathways involved in disease mechanisms.

The vaginal microbiome drives endometriosis pain

This study shows that vaginal microbiome dysbiosis in endometriosis mice causes pain, which can be reversed by antibiotics or microbiome transplants from healthy animals.

Analysis of menstrual effluent uncovers endometriosis-specific cell populations and impaired cellular pathway processes

The paper analyzes menstrual effluent from women with endometriosis to identify immune cell subpopulations and impaired clearance pathways associated with the disease.

Identification and Reproducibility of Novel Combinatorial Genetic Risk Factors for Endometriosis across UK and US Patient Cohorts

This paper identifies and validates novel combinatorial genetic risk factors for endometriosis in UK and US cohorts, showing high reproducibility across diverse populations.

Gene co-expression network reveals key hub genes associated with endometriosis using bulk RNA-seq

Mathematical modelling of macrophage and natural killer cell immune response during early stages of peritoneal endometriosis lesion onset

This study develops a mathematical model of immune responses in early endometriosis, showing reduced cytotoxicity and detection ability drive disease onset.

Single-Cell Profiling Reveals Altered Endometrial Cellular Features Across the Menstrual Cycle in Endometriosis Patients

The paper uses single-cell transcriptomics to analyze endometrial cells from endometriosis patients, revealing altered cellular features and immune communication networks across the menstrual cycle.

Matrix tropism influences endometriotic cell attachment patterns

The paper investigates how matrix tropism affects endometriotic cell attachment patterns on ovarian tissues.

Association Between Dietary Vitamin B1 and the Risk of Endometriosis: A Cross-Sectional Study Based on NHANES 2003-2006

This study examines the association between dietary vitamin B1 intake and endometriosis risk using NHANES 2003-2006 data, finding a significant protective effect at higher intakes.

A Fibronectin (FN)-Silk 3D Cell Culture Model as a Screening Tool for Repurposed Antifibrotic Drug Candidates for Endometriosis

This paper develops a 3D cell culture model using fibronectin-silk matrices to study endometriosis fibrosis and tests pirfenidone as a repurposed antifibrotic drug candidate.

Multiple lesion inductions intensify central sensitization driven by neuroinflammation in a mouse model of endometriosis.

This study shows that repeated endometriosis lesion inductions in mice increase neuroinflammation and central sensitization, leading to chronic pelvic pain.

Spatial Transcriptomic Analysis Identifies Epithelium-Macrophage Crosstalk in Endometriotic Lesions

This study uses spatial transcriptomics to identify increased epithelium-macrophage signaling in endometriotic lesions, highlighting a new role for Complement 3 in lesion inflammation.

Platelets as key cells in endometriosis patients: insights from small extracellular vesicles in peritoneal fluid and endometriotic lesions analysis

This study identifies platelet-derived small extracellular vesicles in endometriosis patients, showing increased platelet biomarker-positive EVs in peritoneal fluid.

Screening and identification of key biomarkers associated with endometriosis using bioinformatics and next generation sequencing data analysis

This study identifies key biomarkers for endometriosis using NGS data analysis, revealing 10 hub genes and potential miRNAs and TFs involved in the disease.

Identification and Diagnostic Potential of Pyroptosis-Related Genes in Endometriosis: A Novel Bioinformatics Analysis

This study identifies pyroptosis-related genes in endometriosis and develops a diagnostic model based on these genes.

Endometriotic lesions exhibit distinct metabolic signature compared to paired eutopic endometrium at the single-cell level

The paper uses single-cell RNA-sequencing to identify distinct metabolic signatures in endometriotic lesions compared to eutopic endometrium, highlighting altered pathways and steroidogenesis-related genes in specific cell types.

Preclinical testing of RRx-001 in mouse models of experimental endometriosis reveals promising therapeutic impacts

This study tests RRx-001 in mouse endometriosis models, showing lesion regression and pain reduction without fertility impact.

Tracing Endometriosis: Coupling deeply phenotyped, single-cell based Endometrial Differences and AI for disease pathology and prediction

The paper creates a large single-cell endometrial atlas and uses AI to identify gene expression and receptor-ligand changes associated with endometriosis, developing predictive models for disease severity.

N-Myc and STAT Interactor is an endometriosis suppressor.

This study identifies NMI as an endometriosis suppressor by showing its role in enhancing IFN-induced apoptosis and inhibiting proliferation and cell adhesion in endometrial cells.

The Association between Endometriosis and Immunological diseases

This study investigates the genetic and phenotypic associations between endometriosis and 31 immunological diseases using UK Biobank data, finding significant genetic correlations and a causal link with rheumatoid arthritis.

Kynurenine monooxygenase blockade reduces endometriosis-like lesions, improves visceral hyperalgesia, and rescues mice from a negative behavioural phenotype in experimental endometriosis.

This study shows that blocking Kynurenine monooxygenase (KMO) reduces endometriosis-like lesions, alleviates pain, and improves behavior in a mouse model of endometriosis.

Mechanophysiology of endometriosis: a non-dimensional physiomarker to detect retrograde flow

The paper proposes a non-dimensional physiomarker to detect retrograde flow in endometriosis by analyzing uterine and fallopian tube peristalsis.

Characterizing the extracellular matrix transcriptome of endometriosis

This study characterizes the matrisome gene expression in endometriosis using GEO datasets, showing its ability to stratify samples and identify significant gene networks.

Impaired bone morphogenetic protein signaling pathways disrupt decidualization in endometriosis

The paper identifies impaired BMP/SMAD signaling as a cause of defective decidualization in endometriosis using transcriptomic and genome-wide binding analyses.

Nociceptor to macrophage communication through CGRP/RAMP1 signaling drives endometriosis-associated pain and lesion growth

This study identifies CGRP/RAMP1 signaling as a driver of endometriosis pain and lesion growth, showing that blocking this pathway reduces pain and lesion size in mice.

Epigenetic age provides insight into tissue origin in endometriosis

The paper uses DNA methylation age to classify endometriosis subtypes by distinguishing between retrograde and non-retrograde origins.

Global Endometrial DNA Multi-omics Analysis Reveals Insights into mQTL Regulation and Associated Endometriosis Disease Risk

The paper analyzes endometrial DNA methylation and genetic variants to identify mQTLs and their association with endometriosis risk and menstrual cycle phases.

Single cell analysis of endometriosis reveals a coordinated transcriptional program driving immunotolerance and angiogenesis across eutopic and ectopic tissues.

This study uses single-cell transcriptomics to analyze endometriosis, identifying novel cell types and mechanisms in both eutopic and ectopic tissues.

Niclosamide targets macrophages to rescue the disrupted peritoneal homeostasis in endometriosis

The paper shows niclosamide improves peritoneal microenvironment in endometriosis by regulating macrophage dynamics and intercellular communication with B cells in a mouse model.

Whole-tissue deconvolution and scRNAseq analysis identify altered endometrial cellular compositions and functionality associated with endometriosis