Ion Channels and Receptors

The paper develops a genetic toolkit to study DRG neuron subtypes, revealing their molecular, morphological, and functional diversity in response to mechanical and thermal stimuli.

This paper introduces GECCO, a thermogenetic system for manipulating calcium levels in cells and tissues, enabling studies of calcium signaling in plants and animals.

This study examines cytokine release in a mouse vaginal ex vivo model after LPS and capsaicin stimulation, finding increased IL-1β levels at 20 hours compared to 4 hours.

The paper develops a computational model of calcium homeostasis in non-excitable cells, showing sustained oscillations in calcium levels due to hysteretic properties and cooperativity in calcium transport mechanisms.

This study shows that deleting TRPC6 in human cortical neurons increases neuronal hyperexcitability by reducing SOCE signaling.

The paper shows that mutations at R2756 in PIEZO2 channels reduce voltage-block, increasing mechanosensitivity in nociceptors and causing hypersensitivity to mechanical pain.

This study identifies phosphatidylserine (PS) as a critical lipid for ASIC1a synaptic targeting and function through electrostatic interactions.

This study identifies Piezo1-mediated mechanosensitive Ca2+ transients in zebrafish DRG satellite glia, showing distinct mechanisms for different types of spontaneous activity.

This study shows TRPA1 inhibition enhances KOR activity in sensory neurons, leading to analgesia, and identifies TRP channel regulation of GPCR activity as a novel mechanism for peripherally mediated pain relief.

The paper uses FM 1-43 dye to identify PIEZO2-expressing neurons involved in mechanosensation, revealing its role in urethral neurons during urination.

The paper identifies a spinal circuit that transmits innocuous cool sensations by characterizing a specific population of interneurons.

This study identifies TrpA1 as a shear stress sensor in Drosophila enteroendocrine cells that regulates intestinal stem cell activity and tissue homeostasis.

This study identifies two mechanosensitive proteins, TRP-4 and MEC-4, that work in parallel to mediate ultrasound-evoked behavioral responses in C. elegans.

This study investigates the role of TRPV4 in sensory neurons in itch behaviors, finding it contributes to histaminergic and partial histaminergic itch but not non-histaminergic itch.

The paper identifies 2-linoleoyl glycerol (2-LG) as an endocannabinoid activated by light in Drosophila photoreceptor cells, which in turn activates TRPC channels.

This paper uses a novel genetically-encoded voltage indicator to study voltage dynamics in primary sensory neurons during various stimuli and injury, revealing synchronization and coding changes.

This study shows that PIEZO2 detects mechanical forces via two pathways, with the IDR5 domain required for cytoskeleton-mediated force transmission and affecting neurite outgrowth inhibition.

The paper investigates proprioception in C. elegans, finding that proprioceptors respond to compressive stresses and encode body posture through mechanosensitive ion channels.

This paper shows that the TRPV channel OSM-9 is required for sleep-dependent olfactory memory in C. elegans, despite being expressed in sensory neurons not involved in butanone attraction.

The paper shows disruption of Ca2+ oscillations in Drosophila perineurial glia leads to seizure-like behavior without affecting BBB structure.

This study shows that TRPM3 upregulation in nociceptors contributes to heat hyperalgesia during inflammation, with pharmacological inhibition reducing TRPV1 and TRPA1 responses.

This study identifies a spliced variant of STIM1, Stim1A, which alters its localization and function in SOCE, adapting Ca2+ entry to specific cellular contexts.

This study identifies Tmem184b as essential for IL-31-induced itch by regulating pruriceptive gene expression and Wnt signaling in DRG neurons.

This study shows TRPV2 activation affects actin cytoskeleton and induces neurite initiation and branching through cAMP level changes in F11 cells.

The paper generates hESC-derived nociceptor-like cells and shows they exhibit mechano-nociceptive characteristics requiring PIEZO2 for mechanotransduction.

The paper shows that two vanilloid ligand bindings per TRPV1 channel are sufficient for maximal pain signaling, revealing how TRPV1 integrates pain signals from multiple stimuli.

The paper identifies a cold-specific neural pathway from the periphery to the parabrachial nucleus, characterized by unique physiological and connectivity properties.

This study shows TRPC3 is essential for functional heterogeneity in cerebellar Purkinje cells by affecting simple and complex spike activity and behavior related to specific modules.

This study shows that simultaneous deletion of TRPV3 and CaV3.2 channels in mice leads to subfertility and impaired Ca2+ homeostasis in oocytes and eggs.

The paper introduces cal-Seq, a pooled knockdown screen using CaMPARI to identify calcium handling genes, finding GPR99 as a regulator of histamine-induced calcium signaling.