Neuroinflammation and Neurodegeneration Mechanisms

This study shows that microglia-derived IL-18 reduces traumatic fear memory by restoring synaptic plasticity and modulating engram cell organization in the hippocampus.

This study shows that tocilizumab improves stroke recovery in aged male mice but requires higher doses for females due to sex-specific differences in sIL-6R levels.

This study uses spatial transcriptomics to compare how Asian and African Zika strains affect microglial states and brain tissue organization in mice, revealing strain-specific mechanisms of neuropathogenesis.

This study shows that the TREM2-R47H variant causes neurodegenerative changes in forebrain organoids and impairs cell integration into the microglial niche.

This paper introduces neuroimmune assembloids, brain organoids with functional microglia-like cells, to study neuroimmune interactions in age-related neurodegenerative diseases.

This study uses human iPSC-derived microglia with high polygenic AD risk to identify functional impairments in immune response, mitochondrial function, and amyloid-beta uptake.

This study identifies brain macrophages in the African turquoise killifish that engulf brain extracellular material, showing age-related decline in engulfment capacity.

The paper develops a label-free method to track morphological changes in iPSC-derived microglia over time and identifies stimulus-specific morphological responses.

This study examines sex- and tissue-specific immune responses to TLR3 activation in mice, finding differential gene and protein expression profiles that may influence alcohol consumption behaviors.

This study shows that microglia depletion in progranulin-deficient mice causes temporary health and behavioral deterioration, with lasting proinflammatory effects in the brain.

This study identifies conserved microglial miRNAs across species and their preserved function in demyelination and remyelination.

The paper identifies PTM enzyme co-expression modules in microglia during cerebral ischemia-reperfusion injury, revealing distinct metabolic, inflammatory, and reparative states with dynamic spatiotemporal patterns.

The paper creates a microglia forebrain assembloid to study human brain development and neuroimmune interactions, showing microglia's role in cortex formation and metabolic changes.

This paper develops a human neuron-microglia tri-culture platform to study cell-cell interactions during cortical development and disease modeling.

This paper demonstrates that attenuated virotherapy with PVSRIPO reprograms microglia to clear neurotoxic debris and enhance immune surveillance in mouse models.

This study identifies meningeal neutrophil infiltration and IL-36γ signaling as key drivers of inflammation-exacerbated pediatric stroke.

The paper identifies microglial transcriptional programs as predictors of inter-individual variation in neuronal aging using single-nucleus RNA sequencing data from 226 adults.

This study integrates iPSC-derived microglia into human midbrain organoids to enhance microglial maturation and inflammatory signaling, revealing altered transcriptional signatures in dopaminergic neurons and astrocytes.

This study shows that CX3CL1/CX3CR1 signaling regulates microglia detection and phagocytosis of dying neurons in the mouse cortex.

This study uses dMRS to show IFN-β increases thalamic tCho diffusivity and age is linked to lower tNAA diffusivity and higher tCho/tCr in white matter.

This paper introduces a protocol to generate sex-specific, high-purity astrocyte cultures from single neonatal mouse brains, avoiding the need for tissue pooling.

This study examines how germ-free conditions affect microglial dynamics in piglets' prefrontal cortex, finding region-specific neuroinflammatory changes in the absence of microbial colonization.

This study investigates how HSV-1 infection remodels microglial transcriptional and epigenetic states, revealing IFN-responsive dominance and loss of homeostatic signatures in specific brain regions.

This study shows CD8+ T cells induce interstrand crosslinking-like DNA damage in neurons, contributing to neurologic dysfunction in viral infections and neurodegenerative diseases.

This study links BBB and glial cell changes to anxio-depressive behaviors and cognitive inflexibility in early-stage 3xTg-AD mice.

This study shows that HLA-DRB1*15:01 causes age- and sex-dependent microglial activation and neuroimmune signaling changes linked to cognitive impairment and inflammation in the CNS.

This study shows that modulating mitochondria-ER contacts reduces inflammasome activation and restores Aβ phagocytosis in AD microglia.

The paper compares Kv and Kir2.1 channel activity in human and mouse microglia, finding significant differences in their regulation and functional responses.

This study identifies a binding site for the TREM2 agonist VG-3927 within the ectodomain hydrophobic groove and shows that Aβ1-42 competes with VG-3927 for binding.

This study compares symptoms from acute microglial activation and systemic inflammation in mice, finding shared and distinct behavioral effects.