Diet and metabolism studies

The Ketogenic Diet Fails to Mitigate Seizures and Neuroinflammatory Responses in a Mouse Model of Virus-Induced Epilepsy

This study shows the ketogenic diet does not reduce seizures or neuroinflammation in a virus-induced epilepsy mouse model, despite altering gut microbiota.

Transforming neural activity to operate without glucose metabolism using brain-derived ketone bodies

This paper shows frogs can sustain neural activity without glucose metabolism by using brain-derived ketone bodies during hibernation, challenging the idea that glucose is essential for brain function.

Hepatic ketogenic insufficiency blunts exercise-induced energy expenditure and alters mitochondrial proteins in skeletal muscle.

This study shows that liver-specific HMGCS2 knockout reduces exercise-induced energy expenditure and alters mitochondrial proteins in skeletal muscle.

Ketogenic diet prevents obesity-associated pancreatic cancer independent of weight loss and induces pancreatic metabolic reprogramming

This study shows that a ketogenic diet prevents obesity-associated pancreatic cancer without weight loss but may promote cancer in non-obese models, altering specific metabolic pathways.

Ketogenic Diet Enhances Cognitive-Behavioral Function and Hippocampal Neurogenesis While Attenuating Amyloid Pathology in Tg-SwDI Mice

This study shows that a ketogenic diet improves cognitive function and reduces amyloid pathology in Tg-SwDI mice with cerebral amyloid angiopathy.

Ketogenic diet dampens excitatory neurotransmission by shrinking synaptic vesicle pools

The paper shows the ketogenic diet reduces excitatory synaptic gain by shrinking synaptic vesicle pools through transcriptional and epigenetic changes in the hippocampus.

Ketone Catabolism is Essential for Maintaining Normal Heart Function During Aging

This study shows that ketone catabolism is essential for maintaining heart function during aging, with ketone supplementation partially rescuing cardiac dysfunction in mice lacking the SCOT enzyme.

Long-term ketogenic diet causes hyperlipidemia, liver dysfunction, and glucose intolerance from impaired insulin trafficking and secretion in mice

Ketosis Elevates Antioxidants and Enhances Neural Function Through Improved Bioenergetics: A 1H MR Spectroscopy Study

This study uses 1H MR Spectroscopy and rsfMRI to show that ketosis increases antioxidants and energy markers while improving neural function through enhanced bioenergetics.

β-Hydroxybutyrate enhances brain metabolism in normoglycemia and hyperglycemia, providing cerebroprotection in a mouse stroke model.

This study shows that β-hydroxybutyrate reduces brain metabolic stress and infarct size in a mouse stroke model under hyperglycemic conditions.

Potential Benefits of Ketone Therapy as a Novel Immunometabolic Treatment for Schizophrenia

This study investigates the effects of ketone ester on neuro-inflammation in a mouse model of acute inflammation, finding it reduces pro-inflammatory cytokine expression.

Dietary fiber content in clinical ketogenic diets modifies the gut microbiome and seizure resistance in mice

This study shows that dietary fiber in ketogenic diets affects the gut microbiome and seizure resistance in mice, with fiber content being more influential than fat type or ratio.

A secondary β-hydroxybutyrate metabolic pathway linked to energy balance

This study identifies a secondary BHB metabolic pathway mediated by CNDP2, leading to BHB-amino acid metabolites that regulate energy balance in mice and humans.

D--hydroxybutyrate stabilizes hippocampal CA3-CA1 circuit during acute insulin resistance.

This study examines how D--hydroxybutyrate affects hippocampal circuit function during acute insulin resistance in mice, showing it rescues neuronal activity and synaptic function.

A long-term ketogenic diet in young and aged rats has dissociable effects on prelimbic cortex and CA3 ensemble activity

This study examines the effects of a ketogenic diet on neural activity in the prelimbic cortex and CA3 of young and aged rats, finding increased activation in the PL but no change in CA3.

Ketolysis is Required for the Proper Development and Function of the Somatosensory Nervous System.

This study shows that ketone metabolism is essential for the development and function of the somatosensory nervous system, with loss of ketolysis causing myelination deficits and proprioceptive impairments.

Ketogenesis Impact on Liver Metabolism Revealed by Proteomics of Lysine β-hydroxybutyrylation

The paper uses proteomics to show that β-hydroxybutyrylation of proteins in mouse liver under ketogenic conditions affects metabolic pathways and enzyme function.

Age and ketogenic diet have dissociable effects on synapse-related gene expression between hippocampal subregions

This study examines how aging and a ketogenic diet affect synapse-related gene expression in different hippocampal subregions, showing subregion-specific changes.

The Anti-Epileptic Ketogenic Diet Alters Hippocampal Transporter Levels and Reduces Adiposity in Aged Rats

This study shows that a ketogenic diet reduces adiposity and reverses age-related declines in hippocampal transporter expression in aged rats.