Psychedelics and Drug Studies

Pharmacologic analysis of non-synonymous coding 5-HT2A SNPs reveals alterations psychedelic drug potencies and efficacies

The paper examines how non-synonymous SNPs in the 5-HT2A receptor gene affect the potency and efficacy of four psychedelic drugs in vitro.

No evidence that LSD microdosing affects recall or the balance between distracter resistance and updating

This study investigates whether LSD microdosing affects working memory recall and distracter resistance vs. updating, finding no significant effects.

Microevidence for microdosing with psilocybin mushrooms: a double-blind placebo-controlled study of subjective effects, behavior, creativity, perception, cognition, and brain activity

This study investigates the effects of microdosing psilocybin mushrooms using a double-blind placebo-controlled design and finds that active doses produce more intense subjective effects, with mixed results on other measures.

The hallucinogenic serotonin2A receptor agonist, DOI, promotes CREB-dependent gene expression of specific plasticity-associated genes in the rodent neocortex

This study shows that the hallucinogenic 5-HT2A agonist DOI increases CREB-dependent expression of plasticity-associated genes in the rodent neocortex.

Stretching and squeezing of neuronal log firing rate distribution by psychedelic and intrinsic brain state transitions

This study examines how psychedelic drugs and intrinsic brain state transitions affect neuronal firing rate distributions in mice, revealing a common pattern of stretching and squeezing in log-rate distributions across different brain states.

Transcriptomics-informed large-scale cortical model captures topography of pharmacological neuroimaging effects of LSD

The paper integrates transcriptomics with large-scale cortical modeling to simulate LSD's effects on brain function, revealing serotonin-2A receptor-mediated changes in cortical connectivity.

Psilocybin-induced changes in brain network integrity and segregation correlate with plasma psilocin level and psychedelic experience

This study shows that psilocin levels and subjective drug intensity correlate with changes in brain network integrity and segregation after psilocybin administration.

Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo

This study shows psilocybin rapidly and persistently increases dendritic spine size and density in mouse frontal cortex, with lasting behavioral and neurophysiological effects.

Lasting effects of a single psilocybin dose on resting-state functional connectivity in healthy individuals

This study examines changes in resting-state functional connectivity after a single psilocybin dose in healthy individuals, finding decreased executive control network connectivity at one-week and a link to increased mindfulness at three-months.

Neural dynamics of stroboscopic stimulation at different stimulation frequencies

This study examines how different stroboscopic stimulation frequencies affect neural dynamics and self-reported experiences, finding that alpha band frequencies cause the most significant changes.

LSD induces increased signalling entropy in rats' prefrontal cortex

This study shows that LSD increases signalling entropy in rats' prefrontal cortex by rewiring gene co-expression networks, suggesting a link between molecular changes and brain entropy.

Neural correlates of the shamanic state of consciousness

This study investigates the neural correlates of the shamanic state of consciousness using EEG in practitioners and controls, finding distinct brain activity patterns compared to psychedelic-induced states.

Baseline power of theta oscillations predicts mystical-type experiences induced by DMT

The paper investigates how baseline theta oscillation power predicts mystical-type experiences induced by DMT and suggests ways to enhance these experiences.

How does it feel to be on psilocybin? Dose-response relationships of subjective experiences in humans.

This study examines how psilocybin dose affects subjective experiences in humans using meta-regression on standardized questionnaires.

Prolonged epigenetic and synaptic plasticity alterations following single exposure to a psychedelic in mice

This study shows that a single dose of the psychedelic DOI causes long-lasting epigenetic and synaptic changes in mice, linked to antidepressant effects and potential risks for psychiatric disorders.

Psilocin acutely disrupts sleep and affects local but not global sleep homeostasis in laboratory mice

This study shows psilocin disrupts sleep patterns and affects local but not global sleep homeostasis in mice, potentially linking to its antidepressant effects.

Effects of LSD are differentially modulated in arrestin knockout mice

This study investigates how LSD affects behavior in mice lacking beta-arrestin 1 or 2, revealing distinct roles for these proteins in mediating LSD's effects.

Increased sensitivity to strong perturbations in a whole-brain model of LSD

This paper uses a whole-brain computational model to simulate perturbations under LSD and finds increased dynamical complexity and recovery time, with strongest effects in resting state networks.

Gamma band alterations and REM-like traits underpin the acute effect of the atypical psychedelic ibogaine

This study investigates the electrophysiological effects of ibogaine in rats, finding increased gamma oscillation power with reduced coherence and complexity, suggesting REM sleep traits in the psychedelic state.

Increased signal diversity/complexity of spontaneous EEG in humans given sub-anaesthetic doses of ketamine

This study investigates how sub-anaesthetic ketamine affects EEG signal diversity and finds increased spontaneous signal diversity correlates with altered consciousness.

A mechanistic model of the neural entropy increaseelicited by psychedelic drugs

This paper develops a mechanistic model explaining how 5HT2A-R activation increases neural entropy in the brain, showing non-uniform regional effects linked to anatomical connectivity.

Psilocybin exerts distinct effects on resting state networks associated with serotonin and dopamine in mice

This study examines how psilocybin affects functional connectivity in mice, revealing distinct changes in serotonin and dopamine-related networks.

DMT alters cortical travelling waves

This study investigates how DMT alters cortical travelling waves during a resting state, finding reduced backward and increased forward waves, supporting a model of altered precision-weighting of priors.

Psilocybin rescues sociability deficits in an animal model of autism

This study shows psilocybin improves social behavior in a prenatal valproic acid-induced ASD mouse model.

Neural and subjective effects of inhaled DMT in natural settings

This study examines the neural and subjective effects of inhaled DMT in natural settings using EEG and psychometric questionnaires, finding changes in brain oscillations and correlations with mystical experiences.

Serotonergic Psychedelics LSD & Psilocybin Increase theFractal Dimension of Cortical Brain Activity in Spatial and Temporal Domains

This paper shows that LSD and psilocybin increase the fractal dimension of brain activity in both spatial and temporal domains, suggesting a shift toward criticality in neural systems.

Decreased Directed Functional Connectivity in the Psychedelic State

This study examines changes in directed functional connectivity during the psychedelic state using MEG and finds a general decrease in directed connectivity for LSD, psilocybin, and low-dose ketamine.

Distinct neural mechanisms for the prosocial and rewarding properties of MDMA

This study identifies distinct neural mechanisms for MDMA's prosocial effects and rewarding properties in mice, showing serotonin transporter and dopaminergic signaling play separate roles.

d-Lysergic acid diethylamide has major potential as a cognitive enhancer

This study shows that d-LSD enhances novel object preference in young and adult rats and can rescue this effect in old rats when combined with enriched environment exposure.

Neural correlates of the DMT experience as assessed via multivariate EEG

This study examines how IV DMT affects EEG brain activity, finding reduced alpha/beta power and increased signal diversity, with delta/theta activity correlating with peak subjective experience.