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Micromachined Thermocouple Microprobe for Real-Time Thermometry of Hippocampal Slices during High-Frequency Stimulation

The paper measures temperature changes in mouse hippocampal slices during high-frequency stimulation, showing that synaptic activity increases local temperature.

Scattering-enabled epi-quantitative phase imaging reveals subcellular detail in organoids and deep mouse brains

This paper introduces SEEQPI, a label-free imaging technique that enables subcellular resolution and deep imaging in turbid tissues, demonstrating its application in organoids and mouse brains.

Development of a Novel Methyl Cellulose Hydrogel with Physiologically-Relevant Controlled Ethanol Release for Cervical Dysplasia Ablation

This paper develops a low-cost methyl cellulose-based ethanol gel for topical treatment of low-grade cervical dysplasia, showing efficacy in vitro and stability under various storage conditions.

Non-mulberry silk fibroin functionalization enhances charge-transfer efficiency in aligned polypyrrole-silk composites for electrically stimulated neurite outgrowth

This paper develops a biohybrid scaffold using functionalized silk fibroin to enhance charge-transfer efficiency, promoting neurite outgrowth in dorsal root ganglion neurons under electrical stimulation.

Quantum Spin Resonance in Engineered Magneto-Sensitive Fluorescent Proteins Enables Multi-Modal Sensing in Living Cells

This paper introduces engineered magneto-sensitive fluorescent proteins that enable quantum sensing in living cells through optically detected magnetic resonance.

Synthetic Mucus Biomaterials Enable Localized Therapeutic Antibody Delivery in Inflammatory Bowel Disease

This study develops synthetic mucin-based hydrogels for localized delivery of anti-TNF- antibodies in IBD, showing improved retention and reduced systemic exposure.

Substituent-based Modulation of Self-Assembly and Immunogenicity of Amphipathic Peptides

This study examines how substituents on benzyl groups affect self-assembly and immunogenicity of amphipathic peptides, showing that chemical modifications influence fibril formation and immune responses.

Molecular Imaging of Collagen Turnover in Myocardial Infarction

This paper evaluates 99mTc-(HE)-(GPO) as a radiotracer for detecting collagen turnover in myocardial infarction, showing higher uptake in infarct zones and specificity for denatured collagen.

Accelerating multi-objective VHH discovery via integrated high-throughput selection and AlphaFold3-guided structure prediction

This paper develops a pipeline combining yeast screening and AlphaFold3 to accelerate discovery of multi-target antibodies, finding that structural predictions improve binding specificity and solubility.

Targeting DNA-LNPs to Endothelial Cells Improves Expression Magnitude, Duration, and Specificity

This study shows that targeting DNA-LNPs to endothelial cells enhances transgene expression magnitude, duration, and specificity in target organs.

Real time monitoring of hydrogenotrophic methanogenesis under deep saline aquifers conditions

The paper develops a high-pressure reactor to monitor methanogenic microbial growth under deep saline aquifer conditions and finds increased methane production with higher H2/CO2 partial pressures.

Combining evolution and machine learning-guided pathway optimization to engineer a novel methylsuccinate module for synthetic C1 metabolism in vivo

This paper combines adaptive laboratory evolution and machine learning to engineer a methylsuccinate module for synthetic C1 metabolism in E. coli, achieving growth in three weeks versus six months with evolution alone.

From Home to Transcriptome: Comparing the transcriptomic profile of induced immune response via lipopolysaccharide stimulation in homeRNA and venous blood

This study compares the transcriptomic profiles of LPS-induced immune responses in homeRNA and venous blood samples, showing homeRNA captures comparable inflammatory responses.

Acoustofluidic patterning for improved microtissue histology

This paper introduces an acoustofluidic device to improve microtissue histology by pre-patterning microtissues in HistoGel, simplifying downstream processing and increasing efficiency.

Programming T cells for Early Cancer Detection with Customized Protease-Activatable Receptors

This paper introduces OncoSCOUT, a method using engineered T cells with protease-activatable receptors to detect early-stage cancer with improved sensitivity compared to existing biomarkers.

MPI-Guided Photothermal Therapy of Prostate Cancer using Stem Cell Delivery of Magnetotheranostic Nanoflowers

This study uses stem cells to deliver magnetic nanoflowers for targeted photothermal therapy, improving tumor retention and enabling MPI-guided ablation with no recurrence.

A modular method for rapidly prototyping targeted gas vesicle protein nanoparticles

The paper describes a modular method to create targeted gas vesicle protein nanoparticles using His-tagged antibody fragments and Ni-NTA functionalization, validated for PSMA targeting.

Risk assessment for condylar stress fracture in elite racing Thoroughbreds using standing computed tomography-based virtual mechanical testing

This study uses 3D finite element analysis on sCT images to estimate strain in Thoroughbred racehorses' third metacarpal bones, finding higher strain in areas with subchondral bone injury, aligning with clinical risk assessments.

Alterations in protein N-glycosylation confer vanadate resistance in Ogataea polymorpha mutants defective in phosphomannosylation

The paper identifies genes responsible for N-glycosylation in Ogataea polymorpha by selecting vanadate-resistant mutants.

A Stretchable Wearable Doppler Ultrasound Patch for Continuous Vascular Monitoring

This paper introduces a wearable Doppler ultrasound patch for continuous vascular monitoring, showing accurate flow velocity measurements in vitro.