A. Li

Pervasive cooperative mutational effects on multiple catalytic enzyme traits emerge via long-range conformational dynamics

The paper quantifies cooperative mutational effects on multiple catalytic traits of a cytochrome P450 enzyme using computational methods and simulations, showing their modulation by long-range conformational dynamics.

Distinct CD8+ T Cell Programming in the Tumor Microenvironment Contributes to Sex Bias in Bladder Cancer Outcome

The paper identifies sex differences in CD8+ T cell programming in bladder cancer, showing male-biased T cell exhaustion and implications for immune checkpoint therapy.

Paxillin Promotes ATP-induced Activation of P2X7 Receptor and NLRP3 Inflammasome

This study identifies Paxillin's role in promoting ATP-induced activation of P2X7 receptor and NLRP3 inflammasome through complex formation and deubiquitination.

Single-shot Mesoporous Silica Rods Scaffold for Induction of Humoral Responses Against Small Antigens

This study demonstrates that a single injection of mesoporous silica rods (MSRs) vaccine can generate potent and durable humoral immunity against small antigens like GnRH and Her2/neu peptides.

Genetic diversity and evolution of Hantaan virus in China and its neighbors

This study analyzes HTNV genetic diversity and evolution in China and neighboring regions, identifying phylogroups, recombination events, and geographic clustering patterns.

Non-invasive red-light optogenetic control of Drosophila cardiac function

This study develops a red-light optogenetic system to noninvasively control Drosophila cardiac rhythms, showing improved efficiency and lower power requirements compared to blue light.

What influences treatment response in animal models of non-alcoholic fatty liver disease? A meta-analysis with meta-regression.

This paper meta-analyzes rodent studies on NAFLD treatments, finding limited efficacy and high bias, suggesting challenges in translating animal results to human therapies.

Biomimetic Aorta-Gonad-Mesonephros on-a-Chip to Study Human Developmental Hematopoiesis

The paper develops a microfluidic AGM-on-a-chip to study human developmental hematopoiesis and demonstrates its ability to induce endothelial-to-hematopoietic transition.

In-Depth Characterization and Validation in BRG1-Mutant Lung Cancers Define Novel Catalytic Inhibitors of SWI/SNF Chromatin Remodeling

This study validates novel BRM/BRG1 ATPase inhibitors as chemical probes for SWI/SNF chromatin remodeling and shows their therapeutic potential in BRG1-mut lung cancers.

Hedgehog pathway activation through conformational blockade of the Patched sterol conduit

This paper develops a nanobody agonist that activates the Hedgehog pathway by stabilizing an alternative conformation of Patched1, disrupting its sterol conduit and providing a new approach for transporter-related drug development.

The inverse relationship between fibronectin and neuroligins in the embryonic rat colon

The paper investigates the inverse relationship between fibronectin and neuroligins in the embryonic rat colon, showing direct regulation and negative correlation.

STING recruits NLRP3 to the ER and deubiquitinates NLRP3 to activate the inflammasome

This study shows STING activates the NLRP3 inflammasome by recruiting NLRP3 to the ER and deubiquitinating it, enhancing IL-1β secretion and inflammatory responses.

SKELETAL MyBP-C ISOFORMS TUNE THE MOLECULAR CONTRACTILITY OF DIVERGENT SKELETAL MUSCLE SYSTEMS

This study examines how different MyBP-C isoforms affect contractility in fast- and slow-twitch skeletal muscles using proteomic, biophysical, and modeling approaches.

Systematic identification of regulators of antibody-drug conjugate toxicity using CRISPR-Cas9 screens

This study uses CRISPR-Cas9 screens to identify genes regulating antibody-drug conjugate (ADC) toxicity, revealing endolysosomal trafficking regulators and mechanisms of ADC resistance.

Effects of Lactobacillus plantarum 15-1 and fructooligosaccharide on the response of broilers to pathogenic Escherichia coli O78 challenge

This study evaluates the effects of Lactobacillus plantarum 15-1 and fructooligosaccharide on broiler chickens challenged with E. coli O78, showing improved intestinal morphology, reduced intestinal injury, and enhanced immune responses.

Repertoire-Based Diagnostics Using Statistical Biophysics

This paper introduces a descriptor-based MaxEnt model for classifying immune repertoires, achieving high accuracy in influenza vaccination status classification with limited samples.

Molecular changes during extended neoadjuvant letrozole treatment of breast cancer: distinguishing acquired resistance from dormant tumours

This study compares molecular changes in dormant and acquired resistant breast cancer tumors during extended letrozole treatment, finding distinct epigenetic alterations in resistant tumors.

Tributyltin induces a transcriptional response without a brite adipocyte signature in adipocyte models

This study shows that tributyltin, an environmental PPARγ ligand, induces adipogenesis but lacks the ability to promote mitochondrial biogenesis or brite adipocyte features compared to rosiglitazone.

Estrogen Signaling in Arcuate Kiss1 Neurons Suppresses a Sex-Dependent Circuit That Promotes Dense Strong Bones in Female Mice

This study identifies estrogen signaling in arcuate Kiss1 neurons as a key regulator of sex-dependent bone density in female mice, revealing a novel neuroskeletal pathway.

Asymmetric migration decreases stability but increases resilience in a heterogeneous metacommunity

Asymmetric migration decreases stability but increases resilience in experimental yeast metacommunities.