A. Li

A new paradigm for personal protection against ticks: efficacy of spatial repellents to reduce host seeking activities in three major tick species of medical importance

This study evaluates the efficacy of spatial repellents against three major tick species using a novel vertical climb assay, finding significant behavioral changes in ticks exposed to certain active ingredients.

The ATLAS™ screening assay reveals distinct CD4+ and CD8+ SARS-CoV-2 antigen response profiles which have implications to Omicron cellular immunity

The paper uses the ATLAS assay to identify CD4+ and CD8+ T cell antigen responses to SARS-CoV-2 variants, revealing common epitopes and predicting Omicron spike mutation impacts.

Scalable production of recombinant three-finger proteins: from inclusion bodies to high quality molecular probes

This paper describes a scalable method for producing high-quality recombinant three-finger proteins using E. coli, enabling their use as molecular probes.

The Gene Knockout of Angiotensin II Type 1a Receptor Improves High-fat Diet-Induced Obesity in rat via Promoting Adipose Lipolysis

This study shows that knocking out the Angiotensin II Type 1a Receptor in rats reduces high-fat diet-induced obesity by enhancing adipose lipolysis through the cAMP/PKA pathway.

A chemical method to sequence 5-formylcytosine on RNA

The paper introduces Mal-Seq, a chemical method to sequence 5-formylcytosine (f5C) on RNA, and shows its presence in mammalian mitochondrial tRNA but not in lower eukaryotes.

Aucubin promoted neuron functional recovery by suppressing inflammation and neuronal apoptosis in a spinal cord injury model

This study shows that aucubin promotes functional recovery after spinal cord injury by reducing inflammation and neuronal apoptosis through the TLR4/NF-κB pathway and mitochondrial protection.

Real-time dynamic single-molecule protein sequencing on an integrated semiconductor device

This paper introduces a method for real-time single-molecule protein sequencing using a semiconductor device, capable of detecting peptides and post-translational modifications with high sensitivity.

A potent human monoclonal antibody with pan-neutralizing activities directly dislocates S trimer of SARS-CoV-2 through binding both up and down forms of RBD

This study identifies a potent human monoclonal antibody, 35B5, that neutralizes SARS-CoV-2 and its variants by targeting a conserved epitope on the RBD, offering a potential therapeutic and vaccine design strategy.

Hypertonic saline and aprotinin based blockage of SARS-CoV-2 specific furin site cleavage by inhibition of nasal protease activity

This study shows that hypertonic saline and aprotinin inhibit SARS-CoV-2 furin site cleavage in nasal proteases, reducing viral entry.

Source-sink connectivity: A novel interictal EEG marker for seizure localization

This paper develops a network-based interictal EEG marker to identify the epileptogenic zone, achieving 79% accuracy in predicting surgical outcomes compared to 43% for clinicians.

Effects of dual deletion of glnR and mtrA on expression of nitrogen metabolism genes in Streptomyces venezuelae

This study examines how the dual deletion of glnR and mtrA affects nitrogen metabolism gene expression in Streptomyces venezuelae, revealing GlnR's decisive role and MtrA's GlnR-dependent regulation.

Protein and Lipid Mass Concentration Measurement in Tissues by Stimulated Raman Scattering Microscopy

The paper introduces NoRI, a SRS microscopy method to measure protein, lipid, and water concentrations in tissues, showing cell-specific variations and disease-related changes in Alzheimer's models.

Reprogramming the neuroblastoma epigenome with a mitochondrial uncoupler

This study uses a mitochondrial uncoupler to actively demethylate DNA in neuroblastoma cells, promoting differentiation and altering the epigenome.

Bayesian metamodeling of complex biological systems across varying representations

This paper introduces Bayesian metamodeling to integrate diverse models of biological systems, demonstrating its application to glucose-stimulated insulin secretion in pancreatic β-cells.

Single-shot rAAV5-based Vaccine Provides Long-term Protective Immunity against SARS-CoV-2 and Its Variants

This study develops a single-dose rAAV5-based vaccine that provides long-term immunity against SARS-CoV-2 and its variants with high neutralizing antibody titers and safety.

Cornering an Ever-Evolving Coronavirus: TATX-03, a fully human synergistic multi-antibody cocktail targeting the SARS-CoV-2 Spike Protein with in vivo efficacy

This paper describes the development of a multi-antibody cocktail (TATX-03) that effectively neutralizes SARS-CoV-2 in vivo and maintains potency against variants of concern.

FXa cleaves the SARS-CoV-2 spike protein and blocks cell entry to protect against infection with inferior effects in B.1.1.7 variant

This study shows FXa cleaves SARS-CoV-2 spike protein, blocking viral entry, but B.1.1.7 variant is resistant, and FXa inhibitors like rivaroxaban reduce this protection.

Identification of a novel lineage bat SARS-related coronaviruses that use bat ACE2 receptor

The paper identifies a novel lineage of SARS-related coronaviruses from bats that use bat ACE2 receptor but not human ACE2, suggesting potential zoonotic risks.

The K18-hACE2 Transgenic Mouse Model Recapitulates Non-Severe and Severe COVID-19 in Response to Infectious Dose of SARS-CoV-2 Virus

The paper characterizes the K18-hACE2 mouse model's response to different SARS-CoV-2 doses, showing dose-dependent disease severity and recovery, and compares it to human COVID-19 pathology.

Phosphatidylserine binding regulates TIM-3 effects on T cell receptor signaling

This study shows TIM-3 promotes NF-κB signaling and IL-2 secretion in Jurkat cells through phosphatidylserine binding, clarifying its role as a co-stimulatory receptor.

MG53 slows neuromuscular junction loss and prolongs survival in ALS

This study shows that MG53 reduces neuromuscular junction loss and extends survival in ALS by protecting diaphragm muscle and NMJ integrity.

Genome of the estuarine oyster provides insights into climate impact and adaptive plasticity

The paper analyzes the genome of the estuarine oyster to show how climate history and physical forces shape genomic diversity and adaptive plasticity through gene expansion and regulatory selection.

Discovery of indole-modified aptamers for highly specific recognition of protein glycoforms

This paper develops indole-modified aptamers using FACS to specifically recognize protein glycoforms, achieving discrimination between structurally similar molecules differing only in glycan modifications.

Structural basis of LhcbM5-mediated state transitions in green algae

The paper reports high-resolution structures of PSI-LHCI-LHCII supercomplex in green algae, revealing the role of LhcbM5 in state transitions and supercomplex formation.

A systematic analysis of rodent models implicates adipogenesis and innate immunity in pathogenesis of fatty liver disease

This study analyzes 3,920 rodent models of NAFLD, finding adipose dysfunction and innate immune perturbation are key factors, and high-fat, high-fructose diets best mimic human NAFLD.

Bone marrow adipocytes drive the development of tissue invasive Ly6Chigh monocytes during obesity

The paper shows that bone marrow adipocyte whitening during obesity drives the increase of invasive Ly6Chigh monocytes, preceding adipose tissue macrophage expansion.

Rational Design and Synthesis of Selective PRMT4 Inhibitors: a New Chemotype for Development of Cancer Therapeutics

This study designs and synthesizes a new class of selective PRMT4 inhibitors with improved selectivity over other PRMT family members.

The transmembrane domain of DWORF activates SERCA directly; P15 and W22 residues are essential.

This study identifies key residues in DWORF that activate SERCA2a by displacing PLB, using FRET biosensors and mutagenesis.

Worldwide tracing of mutations and the evolutionary dynamics of SARS-CoV-2

The paper analyzes SARS-CoV-2 genome sequences to study mutation patterns and evolutionary dynamics, identifying mutations that may enhance viral fitness and provide insights for vaccine development.

Imaging ATP Consumption in Resting Skeletal Muscle: One Molecule at a Time

The paper uses super-resolution microscopy to image single ATP molecule consumption in relaxed rat soleus muscle sarcomeres, revealing two distinct hydrolysis rates with the slower rate localized to the C-zone where MyBP-C is present.