Q. Liu

The paper identifies CD133+ intercellsomes as a mechanism for intercellular communication to compensate for intracellular signal deficits in stress conditions.

This study investigates the evolutionary origins of the first three SARS-CoV-2 variants of concern, finding that they likely evolved within long-term infections in single individuals through multiple mutations.

This study investigates how female zebra finches generalize early learned song preferences to similar songs, finding that preference correlates with syllable overlap with the original tutor song.

This study identifies how flavivirus prM proteins interact with MDA5 and MAVS to inhibit RLR antiviral signaling, revealing species-dependent immune evasion mechanisms.

This study identifies elevated fungal translocation markers in PASC patients, which induce NF-κB inflammation through Dectin-1 signaling.

The paper identifies resR as a target of positive selection in Mtb clinical isolates, linking its mutations to antibiotic resilience and treatment failure.

This paper identifies a potent SARS-CoV-2 antibody, 553-49, that neutralizes the Omicron variant by targeting a conserved epitope and disassembling spike trimers.

The paper tests two chimpanzee adenovirus vectors expressing SARS-CoV-2 spike or nucleocapsid proteins in hamsters, finding that combining them enhances protection against COVID-19.

This study shows Tom70 regulates mitochondrial biogenesis and aging by coordinating transcription and protein import in yeast and Drosophila.

This study identifies aberrant mechanosensitive signaling in vascular endothelial cells as a driver of xanthine oxidoreductase activation and ROS generation, contributing to aortic aneurysm formation in Marfan syndrome.

This study designs bispecific antibodies from non-Omicron neutralizing antibodies that effectively neutralize the Omicron variant and related sarbecoviruses.

The paper assesses Trichoderma biodiversity in Ethiopian coffee rhizosphere soils and evaluates their biocontrol potential against coffee wilt disease.

This study uses molecular barcoding to analyze genetic diversity in Mtb strains, showing L2 strains have distinct growth dynamics and resist BCG vaccination.

This study shows that RfxCas13d causes mouse death by collateral cleavage of 28s rRNA, highlighting biosafety concerns for CRISPR-Cas13 systems.

The paper determines the asymmetric homodimer structure of mouse pendrin using cryo-EM, revealing its electroneutral anion exchange mechanism and pathogenetic mutation properties.

This study identifies hypoxia-regulated ubiquitination of DBC1 by SIAH2 and OTUD5 as a mechanism driving breast cancer progression.

This study uses single-particle tracking to analyze dynein motor behavior in live neurons, revealing that dynein switches between 1-5 motors and requires 2 ATP hydrolysis per step.

The paper identifies a TA system in Mtb, TacAT, where TacT acetylates tRNAs to inhibit translation and Pth reverses this effect, showing Pth's essentiality is unaffected by TacAT's absence.

The paper creates a single-cell atlas of colorectal pre-cancerous polyps, identifying distinct molecular programs in adenomas and sessile serrated lesions and their associations with CRC subtypes.

This study tests if chronic traffic noise affects parental behavior and reproduction in zebra finches, finding increased nest attendance but no impact on offspring outcomes.

This paper presents a chromosome-level genome of Ensete glaucum, revealing insights into chromosomal evolution and repetitive sequence dynamics in the Musaceae family.

The paper investigates the role of parthenogenetic Asian longhorned ticks in spreading SFTSV, finding they contribute to rapid spread and long-range movement.

This paper develops a new mouse model of diffuse midline glioma to evaluate IL13R2-targeted immunotherapies, showing tumors with histopathological features of pediatric gliomas.

The paper tests if AlphaFold-predicted protein structures can be used for sequence-independent molecular replacement in crystallography, successfully determining two unknown contaminant structures.

This study uses additive textile manufacturing to create helically aligned cardiac muscle models, showing improved mechanical function compared to circumferential models.

The paper reports the discovery of a neutralizing nanobody, VHH60, effective against SARS-CoV-2 and its variants, with high potency and protective efficacy in mice.

This paper develops Ub variant inhibitors for JAMM-family DUBs STAMBP and STAMBPL1, showing high affinity and selectivity, with structural insights and improved potency over existing inhibitors.

This paper shows that PSGL-1 is incorporated into HIV-1 virions, reducing infectivity, but also facilitates trans-infection by binding P-selectin.

The paper presents cryo-EM structures of CCKAR with different G proteins to elucidate its G protein coupling promiscuity and ligand recognition mechanism.

This study introduces a new microscopy technique combining deep learning and light-sheet design to visualize organelle interactions in live cells with high spatial and temporal resolution.