X. Li

The paper identifies auranofin as a drug that lowers leptin levels in white adipose tissue and improves insulin sensitivity in obese mice, with anti-diabetic effects.

The paper uses computational methods to predict miRNA-target regulatory modules in soybeans under abiotic stress and identifies stress-related modules with gene ontology enrichment.

This study identifies {Delta}7-DA as the endogenous ligand for Ss-DAF-12 in Strongyloides stercoralis and shows its potential as a therapeutic target when combined with ivermectin.

This study analyzes whole-genome sequences of domestic and wild sheep to uncover introgression events and domestication-related genes in European and Asiatic mouflons.

This study identifies SNP markers associated with salt tolerance traits in upland cotton through genome-wide association analysis.

This study shows hyposalinity stress and Vibrio infection synergistically cause oyster mortality by disrupting microbial balance and triggering immune dysregulation.

This study shows that dietary methionine restriction worsens cancer growth and reduces anti-tumor immunity via gut microbiota and immune suppression in immunocompetent mice.

Sorbitol promotes early flower bud differentiation in loquat by upregulating the MADS-box transcription factor EjCAL through the ERF12 regulatory pathway.

This study shows that transferring gut microbiota from SLE patients to germ-free mice induces lupus-like features, suggesting a causal role for gut microbiota in SLE pathogenesis.

This paper develops a CRISPRi/a approach to reactivate FOXP3 and silence XIST from XCI in human breast cancer cells, showing enhanced epigenetic changes and therapeutic potential.

This paper develops a bispecific antibody, 2022, that neutralizes SARS-CoV-2 and its variants with high potency, showing strong prophylactic and therapeutic effects in a mouse model.

This study identifies a lineage of antibodies from infected rhesus macaques that neutralize 54% of HIV-1 strains by expanding the antibody-Env interface around the V2 loop.

This study examines how soil quality changes after forest conversion to vegetable cropland and tea plantations, showing contrasting effects on microbial community structure and functions.

The paper reports the discovery of a neutralizing nanobody, VHH60, effective against SARS-CoV-2 and its variants, with high potency and protective efficacy in mice.

This paper develops a novel PROTAC, ZL216, using an aptamer as a targeting ligand to selectively degrade nucleolin in breast cancer cells, inhibiting their proliferation and migration.

This study shows that fitness costs of antimalarial drug resistance mutations are significantly higher in nutrient-limited media compared to standard RPMI, suggesting underestimation in typical lab conditions.

This study identifies RTN3 as a proresolving mediator that suppresses antiviral responses by inhibiting TRIM25-mediated K63-linked polyubiquitination of RIG-I, reducing neutrophil infiltration and inflammation.

This study shows that 1,25(OH)2D3 reduces hepatic insulin resistance in diabetic rats by improving antioxidant status and enhancing AKT/GLUT2 expression.

The paper identifies key glucosyltransferase and glucuronosyltransferase enzymes in Scutellaria baicalensis and shows how SbUGAT4 contributes to the high accumulation of baicalin in root tissues.

This study identifies HCV NS5A inhibitors as SARS-CoV-2 exonuclease inhibitors and shows synergy in combination with polymerase inhibitors to enhance antiviral efficacy.

This study demonstrates that iDPC-STEM provides superior contrast and structural detail in biological samples compared to conventional TEM, especially at low doses and for thick sections.

TaBln1 negatively regulates wheat resistance to stripe rust by reducing Ca2+ influx through its interaction with TaCaM3 on the plasma membrane.

This study reports the crystal structure of TmYidC and uses MD simulations to show how the TM1 helix enables YidC to switch between insertase and chaperone conformations.

This paper identifies the tetrameric assembly of AmnC as essential for NAD+ binding and enzymatic activity in 2-aminophenol metabolism.

This study compares single-promoter and dual-promoter lentiviral vectors for CAR expression and cytotoxicity in engineered NK cells, finding that the single-promoter pCDHsp enhances expression and cytotoxicity.

This paper shows that oxidative phosphorylation (OXPHOS) generates most ATP in mouse ESCs and is essential for pluripotency by coupling with the hexosamine biosynthesis pathway to produce UDP-GlcNAc.

This study shows that SETD2 deficiency in mice worsens colonic inflammation and tumorigenesis by increasing oxidative stress and impairing epithelial barrier function.

This study identifies TMEM-120/TMEM120A as a conserved protein that promotes fat storage by enhancing triacylglycerol synthesis and lipid droplet expansion in C. elegans and mammalian cells.

This study identifies DAB2IP as a tumor suppressor in colon cancer that inhibits p53 degradation by competing with GRP75 for binding, thereby enhancing p53 stability and suppressing tumor growth.

This paper shows that SARS-CoV-2 triggers mast cell degranulation, leading to alveolar epithelial inflammation and lung injury, and that MC stabilizers can reduce these effects.