cell-cell communication

Structural topology shapes regional roles in neuronal avalanche initiation and termination

The paper examines how structural brain connectivity influences the initiation and termination of neuronal avalanches using MEG and dMRI data from healthy individuals.

Strain-specific higher-order interactions break phylogenetic conservatism in microbial communities

The paper shows that strain-specific higher-order interactions in microbial communities can override phylogenetic conservatism, demonstrating that strains are not interchangeable even within the same species.

Brainstem premotor circuits transform dental sensory input into coordinated jaw opening

The paper identifies brainstem circuits that transform dental sensory input into coordinated jaw opening by linking sensory afferents to specific motor pools.

P2K1 P2K2 Coordinate Early, Structure-Specific Mechanical Adaptations to Osmotic and Cell Wall Stress in Arabidopsis Roots

This study examines how mechanical properties of the cell wall, plasma membrane, and vacuole in Arabidopsis roots change under osmotic and cell wall stress, revealing a role for P2K1 and P2K2 in PM mechanostasis.

Engineering tunable synthetic fibrotic niches to model acinar-to-ductal metaplasia in 2D pancreatic culture systems

This paper develops a 2D hydrogel platform to study how mechanical and biochemical cues influence acinar-to-ductal metaplasia in pancreatic cells.

Metabolically encoded cell-surface glycoRNA remodeling enhances antitumor immunity

This study shows that tumor cells remodel cell-surface glycoRNA through metabolic reprogramming, impairing immune responses and linking glycoRNA to antitumor immunity and tumor progression.

Reach plans for grasping vs. placing objects evoke different neural dynamics within a shared cortico-cerebellar mechanism.

This study compares neural dynamics during grasping and placing tasks using EEG, finding shared cortico-cerebellar mechanisms with distinct spatiotemporal patterns.

Cross-species multi-omics integration reveals lung alterations in acute kidney injury across mouse, pig, and human airway organoid models

This paper integrates multi-omics data across species to show AKI-induced lung alterations, identifying conserved pathways and human-validated targets for distant organ failure.

Longitudinal Metaproteomic and Lysine Crotonylation Remodeling Defines Clinical Response to Fecal Microbiota Transplantation in Ulcerative Colitis

Shared and genus-specific impact of domestication on mammal oral microbiomes revealed through museomics

This study uses dental calculus metagenomics to show that domestication affects oral microbiomes across three mammalian genera, with genus-specific variations observed.

Genomic characterization of patient derived xenograft models of multiple myeloma reveals selection of multiple pre-existing high risk clones

This study uses SCID-rab PDX models to analyze genomic and transcriptomic features of multiple myeloma, revealing selection of pre-existing high-risk clones.

Decoding plant x environment interactions through spatial gradients in leaf physiology and metabolism

The paper investigates spatial and temporal metabolic and physiological changes in Sansevieria cylindrica leaves under heat, drought, and rewatering conditions, identifying key metabolites that distinguish treatment phases and leaf positions.

Rad53/Chk2 couples mitochondrial outputs and ROS with G2/M cell cycle progression

This study shows Rad53/Chk2 links mitochondrial function and ROS levels to G2/M cell cycle progression in yeast.

Food perception alone stimulates oviposition through serotonin signaling in Drosophila

This study shows that food perception alone, through olfactory signaling and serotonin receptors, stimulates oviposition in Drosophila without requiring nutrient intake.

Spatial transcriptomics unveils the in situ cellular and molecular hallmarks of the lung in fatal COVID-19

This study uses spatial transcriptomics to analyze lung tissue from fatal COVID-19 cases, identifying cellular and molecular changes during disease progression.

Beyond Rate: Hippocampal Phase Codes for Space and Memory

The paper shows that theta-phase timing of spikes encodes spatial and image information beyond firing rate in hippocampal neurons.

N-terminal Trimming Supports Proteostasis Under Secretory Protein Mislocalization Stress

The paper shows that N-terminal trimming of mislocalized secretory proteins helps maintain proteostasis by reducing aggregation and preventing proteasomal degradation.

A microbiota-driven neuroepithelial feed-forward circuit drives gastroesophageal junction tumorigenesis

This paper identifies a microbiota-driven neuroepithelial circuit that promotes GEJ tumorigenesis through bile acid remodeling and bacterial metabolites.

Parathyroid Hormone Receptor 1 Signaling Encodes Multifaceted Metabolic Programs in AgRP Neurons

This study identifies PTH1R signaling in AgRP neurons as a mechanism controlling feeding behavior and nutrient partitioning through distinct kinase activation and lipophagic processes.

Disease progression shapes circadian and locomotor disruption in a model of multiple sclerosis

This study shows that home-cage activity monitoring captures non-motor symptoms in EAE, providing an observer-independent measure of disease progression in MS models.

Dishevelled2 Condensates control Axon Initial Segment (AIS) assembly and function through MTCL1-Dependent microtubule recruitment.

This study identifies Dvl2 as a novel component of the axon initial segment (AIS) and reveals its role in AIS assembly through MTCL1-dependent microtubule recruitment.

Geometric coordination of endothelial invasion and vascular patterning during epithelial morphogenesis

The paper investigates how endothelial cell behavior and tissue deformation coordinate to form vascular patterns during organ development in the mouse epididymis.

MAPKAP Kinase-2 signaling enhances the resolution of colonic inflammation through specialized pro-resolving mediators

This study shows MK2 promotes resolution of colonic inflammation by enabling the switch to specialized pro-resolving mediators, improving inflammation outcomes and tissue repair.

A male-specific neural circuit for appetitive thirst in Drosophila

The paper identifies a male-specific neural circuit in Drosophila that mediates appetitive thirst by integrating neuropeptide signals and regulating motivated behaviors.

The vagus nerve drives cognitive function through the default mode network

This study shows that vagus nerve stimulation activates the default mode network, enhancing cognitive behaviors, while vagal-independent mechanisms affect the salience network.

Leishmania-infected human dendritic cells clear their intracellular parasites by a mechanism involving the cytolytic effector molecules granzyme B and granulysin

This study shows human dendritic cells destroy Leishmania parasites using granzyme B and granulysin, unlike macrophages which are infected and ruptured.

Multimodal phenotyping reveals plant-food-related dietary information in serum Raman spectra of community-dwelling Japanese adults

The paper links dietary patterns with serum Raman spectra and metabolomics in Japanese adults, showing dietary information is distributed across complementary phenotypic layers.

Regional macrophage specialization shapes intestinal neuroimmune function

This study shows that intestinal macrophages have region-specific trophic requirements and neuroimmune functions, with CSF1 playing a key role in small-intestinal nitrergic neuron-macrophage interactions.

Co-targeting KRAS and BCL-2 induces pyroptosis and antitumor tertiary lymphoid structures

This study shows that combining KRAS and BCL-2 inhibition induces pyroptosis and tertiary lymphoid structures in KRAS G12D-mutant lung cancer, enhancing B-cell-dependent antitumor immunity.

APEX2 proximity labeling maps the mGBP2-proximal proteome at the Toxoplasma gondii parasitophorous vacuole

The paper uses APEX2 proximity labeling to identify mGBP2-associated proteins at the Toxoplasma gondii parasitophorous vacuole and finds COX2 is critical for parasite survival.