differential expression

An infusible decellularized extracellular matrix material binds to vasculature in infarcted myocardium and induces pro-reparative gene expression following acute myocardial infarction through inherent avidity and bioactive signaling

This study investigates the effects of different molecular weight components of an intravascularly infusible decellularized extracellular matrix (iECM) on vascular binding and pro-reparative gene expression after myocardial infarction.

ESX-5 Deletions in Mycobacterium tuberculosis Alter Macrophage Cytokine Signaling and Bacterial Heavy Metal Response

This study shows that ESX-5 deletions in Mtb reduce cytokine secretion in macrophages via a post-transcriptional mechanism and alter heavy metal response genes.

Metabolic landscape of inborn errors of metabolism

This study uses metabolomics to analyze 474 subjects with inborn errors of metabolism, identifying genotype-specific metabolic alterations and providing diagnostic tools and a database of metabolomic features.

Population-scale dietary signatures of the oral microbiome

The paper examines diet-oral microbiome associations using metagenomic data from 5,824 participants, finding shared microbial signatures across dietary patterns.

CountAnywhere: frugal cell counting and viability from smartphone hemocytometer photos

CountAnywhere provides a smartphone-based tool for accurate and efficient cell counting and viability assessment using hemocytometer images.

Coordinated Drift of Image Representations in Human EEG

The paper investigates drift in human EEG responses to images across sessions, finding coordinated drift along image identity dimensions and preserved global structure.

Tumour architecture inverts ARNT-dependent growth regulation and reveals CPE-mediated spheroid expansion in luminal breast cancer

This study shows that ARNT's role in breast cancer growth changes with tumor architecture, with CPE mediating spheroid expansion in luminal breast cancer.

Fungal volatiles affect lateral root formation and increase plant tolerance to osmotic stress

This study shows fungal volatiles promote lateral root formation and enhance plant tolerance to osmotic stress by modulating auxin signaling and nutrient transport.

Multi-omics analysis reveals chromatin and transcriptomic remodeling in hippocampal CA1 following adolescent social isolation

Two weeks of post-weaning isolation in male mice altered expression of 106 CA1 genes, enriched for myelination, while chromatin accessibility shifted only at nominal significance and tracked expression weakly.

Susceptibility and cellular responses of COPD airway epithelium to cigarette smoke in stem cell-derived ALI models

This study compares the effects of high-tar and low-tar cigarette smoke on COPD airway epithelium using stem cell-derived ALI models, finding stronger responses to high-tar smoke across multiple molecular dimensions.

Resolution of the circulating pathogenic phenotype of alpha-1 antitrypsin deficiency following liver transplantation

This study evaluates changes in circulating alpha-1 antitrypsin (AAT) monomers and polymers after liver transplantation in PiZZ AAT deficiency patients.

Disrupted RGS coupling underlies a clinically distinct subset of GNAO1-related disorder

The paper identifies a subset of GNAO1 mutations that disrupt RGS coupling, leading to milder clinical symptoms in patients.

NAD+ Replenishment Reduces Cardiomyocyte Senescence and Improves Diastolic Function in the Aged Male Heart

This study shows that NAD+ replenishment with NR or NRH reduces cardiomyocyte senescence and improves diastolic function in aged male mice but not females.

An energy-dependent integrate-and-fire model explains coordinated synaptic and intrinsic adaptation under metabolic stress

The paper develops an energy-dependent integrate-and-fire model to explain how neurons adapt their biophysical parameters under metabolic stress to maintain an optimal energy-information trade-off.

Retinal Phd2 ablation partially rescues Crb1Crb2-associated Leber congenital amaurosis and alters metabolic signaling

This study shows that deleting Phd2 in Crb1/Crb2-deficient mice partially improves retinal function and structure but does not correct underlying defects.

Proteomic profiling of experimental acute alcohol intoxication reveals FGF21 as a specific ethanol-induced hormone

This study identifies FGF21 as a specific ethanol-induced hormone through proteomic profiling of acute alcohol intoxication in humans.

Chemically Engineered Carbon Nanotubes Map Class-Selective Metabolite Enrichment from Human Plasma

The paper maps metabolite corona composition on 25 chemically modified carbon nanotubes in human plasma, showing polymer wrapping and defects influence class-specific enrichment.

Surface curvature promotes coordinated extracellular matrix remodeling and mechanotransductive signaling during osteoblast adaptation

This study examines how substrate curvature affects osteoblast gene expression over time, showing shifts from immediate-early gene activation to ECM remodeling and signaling changes.

Conserved Axonal Transcriptome Dynamics Underlie PGE2-Induced Sensitisation and Identify Tnfrsf12a/Fn14 as a Regulator of Neuronal Excitability in DRG Neurons

The paper identifies a conserved axonal transcriptome involved in PGE2-induced sensitisation and shows Tnfrsf12a regulates neuronal excitability in DRG neurons.

Targeted proteomics informed by long-read RNA-sequencing reveals protein isoform expression associated with bone mineral density

This study uses genetics-guided targeted mass spectrometry to detect protein isoforms associated with bone mineral density, confirming their expression in clinical samples.

Two closely related RNA helicases, UAP56 and URH49, couple mRNA splicing and export pathways with their distinct complexes

This study identifies three splicing regulation patterns mediated by UAP56 and URH49 and their association with mRNA export pathways.

Single-Cell Transcriptomic Analysis of the Immune Response to CHIKVInfection

This study uses scRNA-seq to analyze the immune response to CHIKV infection, finding increased monocytes and dendritic cells, and a strong interferon response driven by monocytes.

Shared genomic signatures of Arctic adaptation among distantly related plant lineages

The paper identifies shared genomic signatures of Arctic adaptation across distantly related plant species by comparing genome assemblies and analyzing selection pressures and repetitive elements.

Model-based inference of gene expression noise from single-cell RNA-sequencing data

This paper introduces a maximum-likelihood framework to estimate gene expression noise from scRNA-seq data, accounting for technical noise and cell type heterogeneity, and demonstrates its reproducibility using yeast data.

Customizable bead-based platform for EV surface protein immunocapture and detection in plasma

This paper introduces a customizable bead-based platform for isolating and detecting specific EV populations in plasma, demonstrating sensitivity and the ability to distinguish clinically relevant biomarker expressions.

Preserved Type 2 Immune Cell Plasticity in Human Obesity and Differential Immune Reconstitution After Bariatric Surgery

This study examines immune cell changes in obesity and after bariatric surgery, finding preserved type 2 immune cell plasticity and differential immune recovery.

mito-overview: a mitochondrial report software

mito-overview integrates mitochondrial coverage, allele fractions, annotations, and read co-occurrence to identify and analyze candidate variants in mitochondrial genomic reports.

Agentic Discovery Transfer Enables Cross-Cancer Discovery at Scale

SMART, a multi-agent framework, transfers findings from single-cell RNA-sequencing cancer studies to other cancer types, identifying cross-cancer prognostic signatures and generating new hypotheses.

Allosteric Biosensors Unravel GTPase-Effector Feedback

The paper introduces GTPase biosensors that report activity without blocking ligand interactions, revealing feedback mechanisms in Rac1 regulation.

Glioblastoma Hijacks Astrocyte Ribosomes to Feul Malignancy through Translatome Reprogramming

This study shows glioblastoma hijacks astrocyte ribosomes via tunneling nanotubes, reprograms the tumor translatome to promote malignancy, and identifies INTS12 as a therapeutic target.