MicroRNA in disease regulation

Circulating microRNAs as biomarkers of chronic kidney disease and its association with renal and cardiovascular outcomes in non-dialysis patients

This study identifies miRNAs as biomarkers for CKD and its cardiovascular outcomes in non-dialysis patients, showing their association with disease progression and mortality.

The structural landscape of Microprocessor Mediated pri-let-7 miRNA processing

This study uses cryo-EM and biochemical analyses to reveal the structural flexibility of the Microprocessor in recognizing and processing different pri-let-7 miRNAs.

A miRNA screen identifies a transcriptional program controlling the fate of adult stem cell

The study identifies miR-106a-3p as a regulator of adult stem/progenitor cell fate through transcriptional control in 3D cultures.

Scanning sample-specific miRNA regulation from bulk and single-cell RNA-sequencing data

The paper introduces Scan, a framework that infers sample-specific miRNA regulation from bulk and single-cell RNA-sequencing data using multiple network inference methods.

Longitudinal Associations Between MicroRNAs and Weight in the Diabetes Prevention Program

This study examines longitudinal associations between circulating microRNAs and weight changes over two years in the Diabetes Prevention Program.

Genetic regulation of microRNAs in the older adult brain and their contribution to neuropsychiatric conditions

The paper identifies miR-QTLs in older adult brains and links four miRNAs to multiple neuropsychiatric and neurodegenerative diseases through integration with GWAS results.

Human microRNA-153-3p targets specific neuronal genes and is associated with the risk of Alzheimer's disease.

This study identifies miR-153-3p as a regulator of neuronal genes and shows its association with Alzheimer's disease risk and pathogenesis.

Advancing microRNA Target Site Prediction with Transformer and Base-Pairing Patterns

The paper introduces Mimosa, a Transformer-based model for miRNA target prediction that incorporates non-canonical base-pairing patterns, achieving better performance than traditional methods.

Cyclic Electromagnetic DNA Simulation (CEDS) can enhance the Functions of Anticancer miR-26a-5p and miR-126-5p in RAW 264.7 cells

CEDS enhances the anticancer effects of miR-26a-5p and miR-126-5p in RAW 264.7 cells by increasing miRNA expression and suppressing key signaling pathways.

Cyclic Electromagnetic DNA Simulation (CEDS) can regulate the Functions of Different miRNAs and DNA Motifs: Protein Signaling Pathways in RAW 264.7 Cells detected by IP-HPLC Analysis

CEDS modulates miRNA and DNA motif interactions, altering protein signaling pathways in RAW 264.7 cells through sequence-specific effects.

MiRNA-21-5p and MiRNA-125-5p Serve as Biomarkers for Diagnosis and Prognosis of Gastric Cancer

This study identifies miRNA-21-5p and miRNA-125-5p as upregulated in gastric cancer, serving as diagnostic and prognostic biomarkers through integrated data analysis and validation.

miRNA synergism impaired metabolic programming of oral cancer cells by selectively enhancing target gene specificity

This study shows that miRNA mimic pairs synergistically reduce target gene expression in oral cancer cells, impairing metabolism and reducing proliferation, but not in normal cells.

Developmental small RNA transcriptomics reveals divergent evolution of the conserved microRNA miR-100 and the let-7-complex in nematodes

The paper performs small RNA sequencing in Pristionchus pacificus to study miR-100 and the let-7-complex, finding novel miRNAs, developmental expression patterns, and alternative locus arrangements.

Gra-CRC-miRTar: The pre-trained nucleotide-to-graph neural networks to identify potential miRNA targets in colorectal cancer

Gra-CRC-miRTar is a pre-trained graph neural network framework for identifying miRNA targets in colorectal cancer, achieving better performance than existing methods and revealing functional interactions.

Quantifying the massive pleiotropy of microRNA: a human microRNA-disease causal association database generated with ChatGPT

The paper introduces miRAIDD, a database of human miRNA-disease causal associations generated using large language models, and quantifies miRNA pleiotropy and its biological characteristics.

PRIMITI: a computational approach for accurate prediction of miRNA-target mRNA interaction

PRIMITI predicts miRNA-target mRNA interactions using machine learning with CLIP-seq and expression data, achieving high AUC scores and outperforming existing methods.

MicroRNA-374b regulates SARS-CoV-2 viral protein mediated endothelial to mesenchymal transition by targeting c-FLIP

This study identifies miR-374b as a regulator of SARS-CoV-2-induced endothelial to mesenchymal transition by targeting c-FLIP, suggesting potential therapeutic strategies for COVID-19-related vascular damage.

miRTarDS: High-Accuracy Refining Protein-level MicroRNA Target Interactions from Prediction Databases Using Sentence-BERT

The paper refines miRNA target interactions using disease similarity features and Sentence-BERT, achieving high accuracy in distinguishing validated from predicted interactions.

Estradiol induces global changes in miRNA expression in endometrial cancer cells and upregulates oncogenic miR-182

This study identifies estradiol-induced miRNAs in endometrial cancer cells, finding miR-182 as an oncomiR that promotes proliferation and inhibits SMAD4.

The miR-144/Hmgn2 regulatory axis orchestrates chromatin organization during erythropoiesis

This study identifies miR-144 and Hmgn2 as key regulators of chromatin condensation during erythropoiesis, showing their conserved role from fish to humans.

Exosomal miRNA-124 is involved in the immune regulation of cervical cancer by regulating CD45 alternative splicing

This study identifies miRNA-124's role in cervical cancer by regulating CD45 alternative splicing and Th cell immune function through the GSK3-PSF-CD45 pathway.

Mime-seq 2.0: a method to sequence microRNAs from specific mouse cell types

The paper introduces mime-seq 2.0, a method to sequence microRNAs from specific mouse cell types using a chimeric RNA methyltransferase tethered to Argonaute.

MicroRNA 21 induces carcinogenesis in hepatic cells by modulating mitochondrial metabolism

This study shows that miR 21 promotes carcinogenesis in hepatic cells by targeting mitochondrial genes, particularly Cox1, leading to reduced oxygen consumption and increased cellular migration.

In-silico analysis of important mitochondrial microRNAs and their differential expression in mitochondria

The paper analyzes the differential expression of 10 mitochondrial microRNAs in cancerous and non-cancerous hepatic cell lines, showing an inverse relationship with their mitochondrial target genes.

Role of miRNA 383 in regulating the mitochondrial machinery and carcinogenesis

The paper investigates miR 383's role in regulating mitochondrial genes and its contribution to carcinogenesis by targeting ND4L and ATP6 in the electron transport chain.

MicroRNA 106b: Role in the reprograming of mitochondrial machinery and carcinogenesis in hepatic cells

The paper investigates miR 106b's role in mitochondrial reprogramming and carcinogenesis in hepatic cells through in-silico analysis.

ELUCIDATION OF THE ROLE OF miRNA 4263 IN DYSREGULATED MITOCHONDRIAL ENERGETICS AND CARCINOGENESIS

The paper identifies miR 4263 as a regulator of mitochondrial energetics and shows its role in promoting carcinogenesis in hepatic cells through altered mitochondrial function.

Regulation of Microprocessor assembly and localization via Pasha's WW domain in C. elegans

The paper identifies residues in Pasha's WW domain critical for Microprocessor assembly and localization in C. elegans.

An imbalance between proliferation and differentiation underlies the development of microRNA-defective pineoblastoma

This study shows that loss of microRNA processing genes leads to tumor development by disrupting proliferation and differentiation balance, and suggests targeting downstream drivers could be therapeutic.

Genetic screen to test microRNA function in peripheral glia morphology

The paper tests microRNA function in Drosophila peripheral glia morphology using microRNA-sponges and finds that miRNA-125 knockdown causes defects, but the cluster and other miRNAs do not, suggesting potential issues with sponge efficacy.