MicroRNA in disease regulation

Effects of human microRNAs 100-5p, 192-5p, and 574-3p on proliferation, migration, and gene expression of human immortalized nasopharyngeal cells

This study investigates the effects of miR-100-5p, miR-192-5p, and miR-574-3p on NP69SV40T cell behavior, finding miR-192-5p reduces migration and RAB2A expression.

Psmd13, a proteosome regulatory subunit identified in miR-29a regulation during neurogenesis

The paper identifies Psmd13 as a regulator of miR-29a during neurogenesis, showing its interaction with Dicer and role in miR-29a expression dynamics.

HuR-Driven Reversible Mitochondrial Shuttling Buffers Cytosolic miRNA Levels in Hepatic Cells

The paper shows that specific miRNAs, including miR-122, are reversibly shuttled to mitochondria in stressed hepatic cells, where they regulate apoptosis-related gene expression and cytosolic miRNA levels.

Hepatic isomiR landscaping reveals new biological insights into metabolic dysfunction in steatotic liver disease

The paper analyzes isomiR expression in MASLD liver biopsies and identifies isomiRs associated with disease severity and fibrosis, proposing novel mRNA targets.

Discovery and therapeutic exploitation of Master Regulatory miRNAs in Glioblastoma

The paper identifies master regulatory miRNAs in glioblastoma and develops a therapeutic delivery method to inhibit tumor growth.

Modulation of microRNA-502-3p significantly influences synaptic activity, dendritic spine density and mitochondrial morphology in the mice brain

This study investigates the in vivo effects of miR-502-3p overexpression and suppression on synaptic activity, mitochondrial morphology, and dendritic spine density in mice.

The strand-selective regulation of miR-155 response to lipopolysaccharide by CELF2, FUBP1 and KSRP proteins

This study investigates how CELF2, FUBP1, and KSRP regulate the strand selection of miR-155-5p and miR-155-3p in response to lipopolysaccharide in macrophages.

Unveiling theranostic potential: Insights into cell-free microRNA-protein interactions

The paper develops a computational approach to analyze miRNA-protein interactions in cell-free environments, identifies key miRNAs and proteins involved in diseases, and highlights therapeutic implications.

Microarray, validation and gene-enrichment approach for assessing differentially expressed circulating miRNAs in obese and lean heart failure patients

The paper identifies and validates differentially expressed circulating miRNAs in heart failure patients with and without obesity, finding three miRNAs upregulated in both groups and associated with biological processes related to HF.

Epithelial miR-149-5p up-regulation is associated with immune evasion in progressive bronchial premalignant lesions

This study identifies hsa-miR-149-5p as a regulator of immune evasion in progressive bronchial premalignant lesions through integrative analysis of RNA and miRNA sequencing data.

Competition effects regulating the composition of the microRNA pool

The paper models pre-miRNA competition for Dicer and validates it using in vitro and ex vivo data, showing that efficient Dicer interaction and TRBP association influence mature miRNA levels.

MiRNA Locker: A Modularized DNA Assembly As miRNA Inhibitors

The paper introduces miRNA Locker, a DNA-based miRNA inhibitor platform that outperforms commercial antagomirs in specificity and efficacy, demonstrating its potential for miRNA research and therapy.

Screening the human miRNA interactome reveals coordinated upregulation in melanoma, adding bidirectional regulation to miRNA networks.

The paper identifies miRNAs that upregulate CD98hc and ST3GAL1/ST3GAL2 in melanoma, revealing a bidirectional regulatory mechanism in miRNA networks.

Tumour suppressor WT1 and its interacting protein RNA helicase DDX5 regulate the microRNA let7/Igf1r axis in the kidney mesenchyme

The paper shows WT1 and DDX5 regulate the let7/Igf1r axis in kidney mesenchyme, linking WT1 mutations to Wilms Tumour through microRNA and IGF signalling pathways.

LIN-67 functionally interacts with heterochronic miRNAs and regulates developmental timing in Caenorhabditis elegans

This study identifies lin-67 as a heterochronic gene that negatively regulates lin-4, let-7, and alg-1, affecting developmental timing in C. elegans.

The human Dicer helicase domain mediates ATP hydrolysis and RNA rearrangement

This study investigates the biochemical activities of the human Dicer helicase domain, showing it hydrolyzes ATP and binds single-stranded RNAs with structural rearrangement.

High-Throughput Quantification of miRNA-3'-Untranslated-Region Regulatory Effects

The paper quantifies miRNA regulatory effects on 3' UTRs using a high-throughput reporter assay and develops a score to predict miRNA inhibition based on seed and seedless sites.

More than half of annotated human miRNAs are never expressed at levels sufficient for biological function

The paper shows that over half of annotated human miRNAs are not expressed at biologically significant levels, challenging the validity of many miRNA function studies.

Comprehensive Network Analysis of miRNA Biogenesis Proteins and Their Ligand Interaction Sites to Identify Novel Targets for Cancer Therapeutics

MiRGraph: A hybrid deep learning approach toidentify microRNA-target interactions by integrating heterogeneous regulatory network and genomic sequences

MiRGraph identifies microRNA-target interactions by integrating sequence and regulatory network data, outperforming existing methods in prediction accuracy and strength estimation.

A comprehensive resource for studying microRNA evolution and microRNA-mediated development and whole-body regeneration in the acoel worm Hofstenia miamia

MirGeneDB 3.0: Improved taxonomic sampling, uniform nomenclature of novel conserved microRNA families, and updated covariance models.

MirGeneDB 3.0 updates the microRNA gene database with expanded species coverage, refined nomenclature, and improved covariance models for phylogenetic analysis.

The opposing mechanisms by which miRNAs critically contribute to differential roles of Nrf1 and Nrf2 in modulating the epithelial-mesenchymal transformation of hepatocellular carcinoma

This study identifies how Nrf1 and Nrf2 regulate miRNAs to differentially modulate EMT in hepatocellular carcinoma cells, with Nrf1 inhibiting and Nrf2 promoting EMT through distinct miRNA pathways.

Unravelling the Impact of miR-21 Overexpression on the MicroRNA Network and Cancer Pathways

This study investigates how miR-21 overexpression affects miRNA networks and cancer-related pathways by identifying miR-17-92a as a potential target and showing shifts in miRNA expression.

Clinical and Molecular Characterization of Glioma Patients: miR-21 Expression as a Prognostic Biomarker in Tissue and Serum

This study evaluates miR-21 expression in glioma tissues and serum, finding it correlates with tumor grade, patient age, and survival, suggesting its potential as a prognostic biomarker.

miRNA Biomarkers in Prostate Cancer: Leveraging Machine Learning for Improved Diagnostic Accuracy

This study uses machine learning to analyze miRNA expression in blood samples to improve prostate cancer diagnosis, achieving 77.42% accuracy and reducing reliance on fixed cutoff values.

An atlas of genetic regulation and disease associations of microRNAs

This study identifies genetic variants influencing miRNA expression and links them to disease associations using genome-wide association studies and Mendelian randomization.

Widespread destabilization of C. elegans microRNAs by the E3 ubiquitin ligase EBAX-1

The paper identifies 22 C. elegans miRNAs destabilized by EBAX-1 loss, showing TDMD is a major miRNA-destabilization pathway with variable 3' sequence dependence.

Stage-specific expression patterns and co-targeting relationships among miRNAs in the developing mouse cerebral cortex

The paper analyzes miRNA expression and co-targeting relationships during mouse cerebral cortex development, identifying stage-specific hubs and enhanced transcriptional silencing effects of miRNA pairs.

Micro-RNA 7975 directly regulates MDTH expression and mediates endothelial cell proliferation and migration in the development of early atherosclerosis

This study shows miR-7975 promotes endothelial cell proliferation and migration by directly regulating MTDH, suggesting its role in early atherosclerosis.