MicroRNA in disease regulation

Functional screening identifies novel miRNAs inhibiting Vascular Smooth Muscle Cell proliferation

The paper identifies seven novel miRNAs that inhibit vascular smooth muscle cell proliferation without inducing apoptosis or senescence.

Interaction between a J-domain co-chaperone and a specific Argonaute protein contributes to microRNA function in animals

This study identifies DNJ-12 as a co-chaperone specific to ALG-1, a miRNA-specific Argonaute in C. elegans, showing its role in miRNA function and gene silencing.

The critical role of isomiRs in accurate differential expression analysis of miRNA-seq data

The paper evaluates isomiR expression differences across conditions and shows their impact on miRNA-seq quantification, highlighting the need for isomiR-aware analysis.

Integrated microRNA and proteome analysis of cancer datasets with MoPC

The paper introduces MoPc, a tool that predicts miRNA-target interactions by analyzing multi-omic data, and validates its results on cancer datasets.

Non-canonical RNA substrates of Drosha lack many of the conserved features found in primary microRNA stem-loops

This study identifies non-canonical Drosha substrates in mouse ESCs, showing they differ from miRNA stem-loops in processing efficiency, stability, and cleavage features.

Antiandrogen Flutamide-Induced Restoration of miR-449 Expression Mitigates Functional Biomarkers Associated with Ovarian Cancer Risk

This study shows flutamide restores miR-449 expression in high-risk ovarian tissues, reducing AR and CSF1R levels and inhibiting cancer cell migration and proliferation.

The RNA-binding activity of the TRIM-NHL protein NHL-2 is essential for miRNA-mediated gene regulation

This study shows that NHL-2's RNA-binding activity is essential for miRNA-mediated gene regulation in C. elegans, linking it to translational repression and miRISC complex function.

RNA-RNA interactions between Respiratory syncytial virus and miR-26 and miR-27 are associated with regulation of cell cycle and antiviral immunity

The paper identifies RNA-RNA interactions between RSV and miR-26/miR-27, showing their roles in cell cycle and antiviral immunity through target gene networks and nuclear localization.

The role of microRNAs to understand sex-based differences in Alzheimer's disease

This paper identifies sex-specific miRNA expression differences in Alzheimer's disease patients through meta-analysis of blood and brain samples, revealing distinct biological process associations in each sex.

Ribosomal protein L24 modulates mammalian microRNA processing and transfer RNA fragment production

This study identifies RPL24 as a regulator of miR processing and tRF production, showing its interaction with DDX5 and its effect on miR levels and tRF profiles in human and plant cells.

An RNAi screen for conserved kinases that enhance microRNA activity after dauer in C. elegans

The paper identifies four kinases whose knockdown causes vulval defects in alg-1(0) C. elegans mutants after dauer, suggesting they regulate miRISC activity during post-dauer development.

Combinatorial microRNA activity is essential for the transition of pluripotent cells from proliferation into dormancy

The paper shows that microRNA activity is essential for early mouse embryos to transition into diapause, with miRNAs regulating gene expression and linking mTOR activity to miRNA biogenesis.

Liver microRNA transcriptome reveals miR-182 as link between type 2 diabetes and fatty liver disease in obesity

The paper identifies miR-182-5p as a key microRNA linking type 2 diabetes and fatty liver disease through its regulation of LRP6 in human and mouse liver samples.

Epitranscriptomic Modification of MicroRNA Increases Atherosclerosis Susceptibility

This study shows that oxidative stress modifies miR-483 to 8OH-G miR-483, leading to endothelial dysfunction and increased atherosclerosis risk through altered targetomes.

MiR-138-5p upregulation during neuronal maturation parallels with an increase in neuronal survival

This study shows that miR-138-5p upregulation during neuronal maturation reduces apoptosis and increases neuronal survival by modulating Caspase3 expression and activity.

Rocket-miR, a Translational Launchpad for miRNA-based Antimicrobial Drug Development

Rocket-miR predicts human miRNA interactions with pathogens to identify potential antimicrobial candidates against antibiotic-resistant infections.

Looking for a needle in a haystack: de novo phenotypic target identification reveals Hippo pathway-mediated miR-202 regulation of egg production

The paper identifies a miRNA phenotypic target through de novo analysis in a medaka model, revealing miR-202 regulation of egg production via the Hippo pathway.

Integrative genome-scale analyses reveal post-transcriptional signatures of early human smallintestinal development in a directed differentiation organoid model

The paper identifies post-transcriptional regulators in early human small intestinal development using multi-omic analyses and presents a web tool for exploring miRNA regulation.

MicroRNA-218 instructs proper assembly of hippocampal networks

This study identifies miR-218 as critical for hippocampal network stability by regulating interneuron function during early development.

In vivo AGO-APP identifies a module of microRNAs cooperatively controlling exit from neural stem cell state

The paper introduces AGO-APP to isolate active miRNAs from Drosophila neural cells, identifies a miRNA module controlling neuroblast to neuron transition, and shows their cooperative function.

Brain cell-specific origin of circulating microRNA biomarkers in experimental temporal lobe epilepsy

The paper identifies brain-originating microRNAs in the blood of mice with experimental epilepsy, supporting their use as biomarkers.

PanomiR: A systems biology framework for analysis of multi-pathway targeting by miRNAs

PanomiR identifies miRNAs regulating groups of interacting pathways by analyzing pathway activity and miRNA-mRNA interactions in gene expression data.

Essential role of the amino-terminal region of Drosha for the Microprocessor function

This study shows that the amino-terminal region of Drosha is essential for pri-miRNA processing and ribosomal protein biogenesis, with Ago2 compensating for Drosha's absence in processing the miR-183 cluster.

The widespread influence of ZSWIM8 on microRNAs during mouse embryonic development

The paper investigates the role of ZSWIM8 in miRNA degradation during mouse embryonic development, finding that its loss leads to developmental defects and altered miRNA accumulation.

Myc-regulated miRNAs modulate p53 expression and impact animal survival under nutrient deprivation

This study shows that dMyc regulates miRNA biogenesis in Drosophila by controlling miRNA gene expression, processing, and activity, with specific effects on nutrient stress response.

Integrative genetic and genomic networks identify microRNA associated with COPD and ILD

The paper identifies miRNAs and isomiRs associated with COPD and ILD through integrative network analysis of RNA-seq and SNP data from lung tissue samples.

microRNA-22 displaces ITAFs from the 5'UTR and inhibit the translation of Coxsackievirus B3 RNA

This study shows miR-22 binds to CVB3 5'UTR, displaces ITAFs, inhibits translation, and reduces viral infection.

Robust Feature Selection strategy detects a panel of microRNAs as putative diagnostic biomarkers in Breast Cancer

This study identifies a panel of 20 microRNAs as potential diagnostic biomarkers for breast cancer using feature selection methods and network analysis.

Target-directed microRNA degradation regulates developmental microRNA expression and embryonic growth in mammals

This study shows that target-directed miRNA degradation (TDMD) regulates miRNA expression and embryonic growth in mammals by deleting Zswim8 and analyzing miRNA changes.

Evaluation of microRNA variant maturation prior to genome edition

The paper evaluates microRNA variant maturation by assessing Drosha-dependent cleavage efficiency to identify variants that accumulate at wild-type levels.