Cellular Mechanics and Interactions

This study identifies integrin-dependent mechanisms essential for maintaining simple epithelial architecture in Drosophila by integrating live imaging, biophysical measurements, and BM property manipulation.

The paper shows ECM stiffness alters nuclear lamina composition and PRC2-mediated gene repression through changes in chromatin structure and motion.

This study investigates how the apical extracellular matrix (aECM) regulates fold morphogenesis in the Drosophila wing disc, showing its role in stabilizing tissue folding and shaping the adult wing.

This study develops a multiscale model to explore how integrin activation, clustering, and internalization influence cell-substrate adhesion dynamics and migration behavior.

The paper shows that rotational migration in Drosophila egg chambers is initiated by a feedback loop involving Fat2 and tissue geometry, revealing a biophysical mechanism for self-organized collective motion.

The paper models immune cell migration by integrating nuclear piston, uropod, and microenvironment mechanics to show how they synergize for efficient movement through dense tissues.

This paper introduces 3DTubularVoronoi, a simulation framework for modeling 3D tubular epithelial morphogenesis and stable cell packing, capturing scutoid formation and dynamic rearrangements.

This paper develops a computational model to study how cancer cells interact with and remodel the extracellular matrix, revealing how structural and chemical cues influence invasion.

This study shows that mechanical stretching can disrupt pathological crosslinks in fibrotic tissues, reversing fibrosis in mice when combined with pharmacological treatment.

The paper shows that actin flows sort membrane proteins based on their affinity for actin, leading to specific clustering and patterning.

This study compares the proteome of Calu-3 cells in 2D monolayers and 3D Matrigel spheroids, finding that 3D architecture drives major proteomic changes, while Matrigel's biochemical cues induce smaller but significant shifts.

This study uses a hybrid in vivo model to show that the aged extracellular matrix promotes breast cancer progression, with LOX identified as a key driver.

The paper investigates how the nucleus integrates mechanoprotection and mechanosensing during EMT by analyzing spatial patterns of chromatin response to mechanical forces.

The paper shows that cell exit during EMT in Drosophila is mechanically driven by apical detachment requiring Spectrin, independent of E-Cadherin loss.

This study shows that LOX-mediated collagen crosslinking affects collagen dynamics and cell-matrix interactions through focal adhesions.

The paper investigates how apical forces drive optic cup invagination during vertebrate eye development through coordinated cell behaviors and physical modeling.

This study shows that cancer-associated fibroblasts enhance breast cancer cell migration via laminin-511-induced cortical Arp2/3 localization.

The paper identifies a tension-sensitive intermediate state in endothelial cells during non-inflammatory activation, which regulates actin dynamics and barrier function through VE-cadherin and MLC-dephosphorylation.

This study shows that cyclic mechanical loading disrupts cytoskeletal symmetry in 3D scaffolds by combining matrix strain and fluid shear stress.

This study shows that substrate availability determines the morphogenetic strategy used for body axis elongation in gastruloids, with distinct cytoskeletal dependencies.

The paper identifies a TRPM7-Annexin A1 pathway that enables circulating tumor cells to adapt to fluid shear stress in capillaries, facilitating metastasis.

This study shows that dynamic basal cell contacts during mitosis influence tissue packing in mammalian epithelia, confirmed through in silico modeling and organoid experiments.

The paper investigates how directional cell motility drives side-branching in the mammary epithelium, showing that actomyosin network tension influences branching frequency.

This study develops a biophysical model integrating osmolarity and biomechanical feedback to explain stress-dependent growth in breast cancer spheroids, revealing a cellular volume checkpoint for mitosis.

The paper shows antiparallel cell circulation arises from self-aligned polarity-dependent tension gradients in confluent tissues.

This study shows that MYO10 knockdown in HeLa and COS7 cells reduces proliferation and migration, alters filopodia formation, and increases spreading on laminin, indicating MYO10's role in cell motility and adhesion.

This study shows that inhibiting ezrin reduces mechano-protection in cells by altering actin organization and increasing stress fibre formation, which is mitigated by formin inhibition.

This paper shows that ROCK2 inhibition reduces ECM remodelling and cell growth while impairing migration and invasion in breast cancer models.

This study identifies a mechanotransduction pathway in cancer-associated fibroblasts (CAFs) where BRAF inhibition and matrix stiffness converge to drive nuclear remodeling and CAF activation through the ROCK-cytoskeleton-nucleus axis.

This study shows that inorganic phosphate (Pi) in the Arp2/3 complex stabilizes actin filament branches, with Pi release rates and force-dependent stability affecting branch stability and regrowth.