Cellular Mechanics and Interactions

Body-Axis Reorientation in Regenerating Hydra under Geometric Confinement

This study shows that geometric confinement overrides inherited body-axis orientation in regenerating Hydra, leading to reorientation aligned with the confining channel.

CD44 and Ezrin restrict EGF receptor mobility to generate a novel spatial arrangement of cytoskeletal signaling modules driving bleb-based migration

The paper investigates how CD44 and Ezrin restrict EGF receptor mobility to create a spatial signaling gradient that stabilizes bleb-based migration in non-adhesive environments.

SERPINE1-AP2A1 interplay links substrate stiffness to fibroblast senescence

This study shows that substrate stiffness influences fibroblast senescence through the SERPINE1-AP2A1 interaction, affecting cytoskeletal remodeling and senescence-associated secretory phenotype factors.

Prolonged Crowding Initiates Tumor Invasion with Mechanomemory by Pressure-Sensation of Membrane Domains

This study shows that prolonged crowding induces an invasive phenotype in cancer cells through mechanomemory, mediated by membrane domain disaggregation under compressive stress.

Endothelial adaptation to complex flow patterns in a novel in vitro model predicted by computational fluid dynamics

This paper develops an in vitro model of complex flow patterns using engineered geometries and computational fluid dynamics to study endothelial cell adaptation to hemodynamic forces.

Matrix viscoelasticity regulates dermal fibroblast activation in a three-dimensional fibrillar microenvironment

This study shows that fibroblast activation is influenced by matrix viscoelasticity in 3D fibrillar microenvironments, with slow stress relaxation and stiffness promoting activation and ECM remodeling.

Mechanics-Driven Emergence of Mesenchymal Migration Features

This paper introduces a 2D in silico model of mesenchymal cell migration driven by traction forces, showing how adhesion dynamics and force balance govern migration patterns without requiring directional bias.

Mechanical regulation of cellular energy metabolism in cancer microenvironments

The paper develops a model linking matrix stiffness and ligand density to cellular bioenergetics in cancer cells, showing how mechanical forces influence metabolic pathways and contractility.

Design and Validation of a 3D-Printed Motorized Biaxial Cell Stretching Device

This paper designs and validates a 3D-printed motorized biaxial cell stretching device to study cellular responses to mechanical strain, showing differential effects of biaxial versus uniaxial stretching.

Cofilin controls actin network identity by sorting actin binding proteins to distinct cytoskeletal structures

This study shows that cofilin regulates actin network structure and ABP sorting by controlling disassembly, affecting intracellular transport and ABP localization.

Three Dimensional Dynamics of Epithelial Monolayers

This paper uses quantitative phase imaging to study 3D dynamics of epithelial monolayers, revealing mass conservation and non-prismatic cell geometry challenges to 2.5D assumptions.

DLC1 loss drives multicellular streaming invasion by enforcing spatially coordinated Rho and β1 integrin signaling

The paper shows DLC1 loss promotes multicellular streaming invasion by coordinating Rho and β1 integrin signaling in collagen-rich ECM.

Substrate stiffness and viscoelasticity influence fibroblast senescence

This study shows that hydrogel stiffness and viscoelasticity influence fibroblast senescence, with viscoelasticity uniquely promoting senescence even without genotoxic stress.

A Multiscale Computational Framework Linking Cortical Microtubule Dynamics to Plant Tissue Morphogenesis

This paper develops a multiscale computational framework linking cortical microtubule dynamics to plant tissue morphogenesis, showing that stochastic coupling between MT organization and cell geometry generates growth anisotropy.

Dissecting the Dynamic Evolution of Tensional Homeostasis in Fibroblasts using an Integrated Biomechanical Bioreactor Platform

This study uses a biomechanical bioreactor to show that fibroblasts adjust stress dynamically with collagen concentration, revealing a balance between contractility and matrix densification.

Structural mechanisms of drebrin-mediated F-actin network modulation

This study uses cryo-EM to reveal drebrin's structural interaction with F-actin through two domains, explaining its modulatory role in actin networks and competitive binding with other proteins.

Modelling Plant Cortical Microtubules: Curvature Sensing from Bending Energy

This paper models plant cortical microtubules to show how curvature sensing from bending energy influences their organization on complex surfaces, revealing new roles for proteins in navigating high-curvature edges.

Soft silicone surface stiffening by oxidation upon deep UV treatment as characterized using nanoindentation

This study shows that deep UV treatment increases the surface stiffness of soft silicones without affecting their bulk properties, as measured by nanoindentation and spectroscopy.

Adhesion and polarity-driven morphogenesis: Mechanismsand constraints in tissue formation

This study uses a computational model to show that two parameters—polarity strength and its regulation—determine five basic morphogenetic patterns in embryos.

Mechanical Checkpoint for Cell Division in Three-Dimensional Microenvironments

The paper identifies three modes of ECM resistance during cell division in 3D microenvironments and highlights the dominance of pericellular shear resistance.

Structural basis of nonmuscle myosin-2 autoinhibition mechanisms

The paper presents the cryo-EM structure of human NM2B in the autoinhibited 10S conformation, revealing structural mechanisms of autoinhibition and implications for disease.

Persistent Post-Inflammatory Matrix Stiffening Defines a Premalignant Mechanical Niche in Ulcerative Colitis-Associated Neoplasia

This study identifies persistent post-inflammatory matrix stiffening as a premalignant mechanical niche in UC-associated neoplasia, showing its role in epithelial remodeling and potential therapeutic targeting.

Emergent Tissue Rheology in a 3D Mechanically Adaptive Viscoelastic Cell Network Model

The paper introduces a 3D viscoelastic cell-network model that links single-cell interactions to tissue rheology, validated against experimental assays.

Non-muscle myosin II acts non-cell autonomously to guide collective migration of the zebrafish polster cells

The paper investigates the non-cell-autonomous role of non-muscle myosin II in guiding collective migration of zebrafish polster cells through mechanical signaling.

Vimentin promotes collective cell migration through collagen networks via increased matrix remodeling and spheroid fluidity

Cyclic stretch inhibits cell invasion in 3D scaffolds

This study shows cyclic stretch inhibits cell invasion in 3D scaffolds, with suppression inversely related to cell contractility.

Cellular timing heterogeneity regulates phase transitions in living matter

The paper shows that cellular timing heterogeneity regulates rigidity transitions in zebrafish embryos by influencing cell cycle length and tissue-wide mechanical states.

Three-Dimensional Mechanical Cooperativity Optimises Epithelial Wound Healing

This study identifies a 3D mechanical mechanism in Drosophila wing disc epithelia that enhances wound healing through coordinated cell shape changes and intercalations.

Basement membrane turnover drives filopodial protease-independent invasion

This study shows that basement membrane turnover and filopodia can drive protease-independent invasion through mechanical deformation and pore enlargement.

Quantifying Intracellular Mechanosensitive Response upon Spatially Defined Mechano-Chemical Triggering

This study uses FluidFM and FLIM to analyze how A-type and B-type lamins and microtubules respond to mechanical and chemical cues, revealing distinct roles in nuclear elasticity and viscous response.