Fatty Acid Research and Health

Integrated tissue proteomics and lipidomics from ovine organs suggests novel functional implications for fatty acids and lipid mediators.

The paper integrates proteomics and lipidomics data from sheep organs to functionally annotate lipid mediators and identify novel roles for fatty acids in protein synthesis and inflammation resolution.

A diet enriched in highly poly-unsaturated fatty acids alters immune cell lipid composition and ferroptosis susceptibility

This study shows that a high PUFA diet increases PL-PUFA content in immune cells and enhances their susceptibility to ferroptosis.

MAPKAP Kinase-2 signaling enhances the resolution of colonic inflammation through specialized pro-resolving mediators

This study shows MK2 promotes resolution of colonic inflammation by enabling the switch to specialized pro-resolving mediators, improving inflammation outcomes and tissue repair.

DHA Increases Angptl4 Gene Expression and Reduces LPL Activity in a PPARγ-dependent manner in Adipocytes

DHA deficiency drives neural oxidized-lipid stress and microglial activation

This study shows that DHA deficiency causes lipid remodeling and microglial activation in mice, leading to oxidative stress and visual dysfunction, with APOE-dependent lipid disposal and galectin-3 involvement.

Effects of Polyunsaturated Fatty Acids and Selenoneine on Growth and Lipidomic Profiles in Patient-Derived Prostate Cancer Organoids

This study investigates the effects of omega-3 and omega-6 fatty acids, along with selenoneine, on growth and lipidomic profiles of patient-derived prostate cancer organoids.

Alpha-linolenic acid and dietary protein minimally but differentially regulate white adipose tissue lipolysis in female mice fed moderate-fat diets

This study shows that high alpha-linolenic acid diets minimally affect lipolytic markers in female mice, contrasting with male mice findings.

Reorganization of innate immune cell lipid profiles by bioinspired meroterpenoids to limit inflammation

The paper identifies meroterpenoids that alter immune cell lipid profiles to reduce inflammation by targeting lipid mediator biosynthesis pathways.

Dietary omega-6 arachidonic acid and omega-3 docosahexaenoic acid supplementation differentially impact skeletal muscle inflammaging in mice

This study shows that long-term dietary ARA and DHA supplementation have different effects on aging muscle structure and function in mice.

Discovering a new biocatalytic potential of milk fat globules: in situ conversion of exogenous docosahexaenoic acid to its oxylipins

This study shows that milk fat globules can convert exogenous DHA into oxylipins through enzymatic activity, suggesting their potential as biocatalysts and lipid carriers.

Long-chain Polyunsaturated Fatty Acids Mitigate In Vitro Skeletal Muscle Wasting Induced by Colorectal Carcinoma Cells via a 15-LOX-dependent Pathway

This study shows that specific long-chain polyunsaturated fatty acids (LC-PUFAs) reduce CRC-induced muscle wasting in vitro by activating 15-LOX-dependent pathways and producing specialized pro-resolving lipid mediators.

Social isolation of aged mice drives dramatic release of inflammatory lipoxygenase-derived oxylipins

This study shows social isolation in aged mice increases inflammatory oxylipins in multiple organs but not serum, with exercise failing to reduce these effects.

N-3 Polyunsaturated Fatty Acids Ameliorate Post-infarction Cardiac Dysfunction Through Modulation Of Adiponectin-Ceramide Metabolism

This study shows that n-3 PUFA reduces myocardial infarction damage by modulating adiponectin-ceramide metabolism, with no significant difference between triglyceride and phospholipid forms.

Phagocytosis of primary human macrophages is elevated by ex vivo supplementation with n-3 PUFA

This study shows that ex vivo supplementation of primary human macrophages with n-3 PUFAs increases phagocytosis, likely through reduced PGE2 levels rather than direct oxylipin effects.

Erythroblast-derived mediators program neutrophil development and function

This study identifies erythroblasts as a source of SPMs that regulate neutrophil development and function, showing that Alox15 depletion in erythroblasts leads to neutrophil dysfunction and impaired bacterial clearance.

Nanoliposomal Omega-3 Fatty Acids Promote Adult Hippocampal Neurogenesis through the BDNF/TrkB Pathway in C57BL/6 Mice

This study shows that nanoencapsulated omega-3 fatty acids improve hippocampal neurogenesis in mice by enhancing BDNF/TrkB pathway activity and Fabp5 expression.

Herring roe PLs promote SPM biosynthesis in macrophages and a keratinocyte/fibroblast co-culture as model of psoriasis

This study shows herring roe phospholipids promote SPM biosynthesis in macrophages and a keratinocyte/fibroblast co-culture, suggesting a mechanism for resolving psoriatic inflammation.

Deuterated Polyunsaturated Fatty Acids Alleviate In Vitro Skeletal Muscle Dysfunction Induced by Oxidative Stress

This study shows deuterated PUFAs reduce oxidative stress-induced skeletal muscle dysfunction by limiting lipid peroxidation and modulating antioxidant responses.

Eicosapentaenoic Acid Enhances Angiogenesis and Reperfusion After Ischemia: Comparative Effects of Omega-3 Fatty Acids in a Murine Hind Limb Model

This study compares the effects of EPA and DHA on angiogenesis and reperfusion in a murine hind limb ischemia model, finding EPA enhances reperfusion and angiogenesis while DHA does not.

Quantification of esterified oxylipins following HILIC-fractionation of lipid classes

This study develops a HILIC-based lipid fractionation method to directly quantify esterified oxylipins in plasma, revealing their lipid class binding preferences and dietary influences.

Deep White-Matter Pathways Mediate the Link Between Docosahexaenoic Acid (DHA) Status and Cognitive Performance in Adolescence

The paper identifies a deep white-matter pathway linking DHA status to cognitive performance in adolescents using multimodal MRI and Bayesian modeling.

In vivo AAV9-SB-CRISPR screen identifies fatty acid elongase ELOVL5 as a pro-resolving mediator in lung inflammation

Maternal n-3 PUFA deficiency alters brain fatty acid and oxylipin profiles across perinatal development in offspring

Omega-3 Fatty Acid Derived Neuroactive Lipids - Docosahexaenoyl-Glycine and Its Epoxide Metabolites are Multifunctional Lipid Mediators

The paper identifies NA-Gly, DHA-Gly, and their epoxide derivatives as multifunctional lipid mediators with anti-inflammatory properties and selective receptor modulation, suggesting therapeutic potential for neuroinflammation.

EFFECT OF OMEGA 3 SUPPLEMENTATION DURING PREGNANCY AND LACTATION ON COGNITIVE FUNCTIONS IN RAT OFFSPRING

This study examines the impact of omega-3 supplementation during pregnancy and lactation on cognitive functions of rat offspring, finding improved spatial learning and memory.

Leukocyte-type 12/15-lipoxygenase is essential for timely inflammation-resolution and effective tissue regeneration following skeletal muscle injury

This study shows that 12/15-LOX is essential for inflammation resolution and skeletal muscle regeneration by regulating lipid mediators and myogenic progenitor cell function.

Effects of One-week Intake of Different Edible Oils on the Urinary Proteome of Rats

This study examines how one-week intake of different edible oils affects the urinary proteome and post-translational modifications in rats, revealing varied biological pathway enrichments across groups.

Divergent Effects of Ultra-High Dose Arachidonic Acid versus Docosahexaenoic Acid on MYCN-Driven Neuroblastoma Progression in a Syngeneic Mouse Model

This study shows that ultra-high dose arachidonic acid promotes neuroblastoma growth in mice, while docosahexaenoic acid suppresses tumor progression and survival.

Whey Protein Phospholipid Concentrate Supplementation Prevents High-Fat Diet Induced Cognitive Impairment in Wistar Rats by Promoting Brain Neuronal Connectivity and Sphingolipid Clearance

WPPC supplementation prevents high-fat diet-induced cognitive impairment in rats by improving neuronal connectivity and reducing sphingolipid levels in the hippocampus.

Decomposed interaction testing improves detection of genetic modifiers of the relationship of dietary omega-3 fatty acid intake and its plasma biomarkers with hsCRP in the UK Biobank

The paper introduces a decomposition approach to detect genetic modifiers of the relationship between dietary omega-3 fatty acids, plasma biomarkers, and hsCRP in the UK Biobank, improving statistical power.