Fatty Acid Research and Health

A diet enriched in highly poly-unsaturated fatty acids alters immune cell lipid composition and ferroptosis susceptibility

This study shows that a high PUFA diet increases PL-PUFA content in immune cells and enhances their susceptibility to ferroptosis.

MAPKAP Kinase-2 signaling enhances the resolution of colonic inflammation through specialized pro-resolving mediators

This study shows MK2 promotes resolution of colonic inflammation by enabling the switch to specialized pro-resolving mediators, improving inflammation outcomes and tissue repair.

DHA deficiency drives neural oxidized-lipid stress and microglial activation

This study shows that DHA deficiency causes lipid remodeling and microglial activation in mice, leading to oxidative stress and visual dysfunction, with APOE-dependent lipid disposal and galectin-3 involvement.

Effects of Polyunsaturated Fatty Acids and Selenoneine on Growth and Lipidomic Profiles in Patient-Derived Prostate Cancer Organoids

This study investigates the effects of omega-3 and omega-6 fatty acids, along with selenoneine, on growth and lipidomic profiles of patient-derived prostate cancer organoids.

Alpha-linolenic acid and dietary protein minimally but differentially regulate white adipose tissue lipolysis in female mice fed moderate-fat diets

This study shows that high alpha-linolenic acid diets minimally affect lipolytic markers in female mice, contrasting with male mice findings.

Dietary omega-6 arachidonic acid and omega-3 docosahexaenoic acid supplementation differentially impact skeletal muscle inflammaging in mice

This study shows that long-term dietary ARA and DHA supplementation have different effects on aging muscle structure and function in mice.

Discovering a new biocatalytic potential of milk fat globules: in situ conversion of exogenous docosahexaenoic acid to its oxylipins

This study shows that milk fat globules can convert exogenous DHA into oxylipins through enzymatic activity, suggesting their potential as biocatalysts and lipid carriers.

Long-chain Polyunsaturated Fatty Acids Mitigate In Vitro Skeletal Muscle Wasting Induced by Colorectal Carcinoma Cells via a 15-LOX-dependent Pathway

This study shows that specific long-chain polyunsaturated fatty acids (LC-PUFAs) reduce CRC-induced muscle wasting in vitro by activating 15-LOX-dependent pathways and producing specialized pro-resolving lipid mediators.

N-3 Polyunsaturated Fatty Acids Ameliorate Post-infarction Cardiac Dysfunction Through Modulation Of Adiponectin-Ceramide Metabolism

This study shows that n-3 PUFA reduces myocardial infarction damage by modulating adiponectin-ceramide metabolism, with no significant difference between triglyceride and phospholipid forms.

Erythroblast-derived mediators program neutrophil development and function

This study identifies erythroblasts as a source of SPMs that regulate neutrophil development and function, showing that Alox15 depletion in erythroblasts leads to neutrophil dysfunction and impaired bacterial clearance.

Nanoliposomal Omega-3 Fatty Acids Promote Adult Hippocampal Neurogenesis through the BDNF/TrkB Pathway in C57BL/6 Mice

This study shows that nanoencapsulated omega-3 fatty acids improve hippocampal neurogenesis in mice by enhancing BDNF/TrkB pathway activity and Fabp5 expression.

Eicosapentaenoic Acid Enhances Angiogenesis and Reperfusion After Ischemia: Comparative Effects of Omega-3 Fatty Acids in a Murine Hind Limb Model

This study compares the effects of EPA and DHA on angiogenesis and reperfusion in a murine hind limb ischemia model, finding EPA enhances reperfusion and angiogenesis while DHA does not.

Deep White-Matter Pathways Mediate the Link Between Docosahexaenoic Acid (DHA) Status and Cognitive Performance in Adolescence

The paper identifies a deep white-matter pathway linking DHA status to cognitive performance in adolescents using multimodal MRI and Bayesian modeling.

Maternal n-3 PUFA deficiency alters brain fatty acid and oxylipin profiles across perinatal development in offspring

Omega-3 Fatty Acid Derived Neuroactive Lipids - Docosahexaenoyl-Glycine and Its Epoxide Metabolites are Multifunctional Lipid Mediators

The paper identifies NA-Gly, DHA-Gly, and their epoxide derivatives as multifunctional lipid mediators with anti-inflammatory properties and selective receptor modulation, suggesting therapeutic potential for neuroinflammation.

Divergent Effects of Ultra-High Dose Arachidonic Acid versus Docosahexaenoic Acid on MYCN-Driven Neuroblastoma Progression in a Syngeneic Mouse Model

This study shows that ultra-high dose arachidonic acid promotes neuroblastoma growth in mice, while docosahexaenoic acid suppresses tumor progression and survival.

Whey Protein Phospholipid Concentrate Supplementation Prevents High-Fat Diet Induced Cognitive Impairment in Wistar Rats by Promoting Brain Neuronal Connectivity and Sphingolipid Clearance

WPPC supplementation prevents high-fat diet-induced cognitive impairment in rats by improving neuronal connectivity and reducing sphingolipid levels in the hippocampus.

A multi-level gene-diet interaction analysis of fish oil supplementation and 14 circulating polyunsaturated fatty acids-related traits identifies the FADS and GRP12 loci

The paper identifies gene-diet interactions for fish oil supplementation and PUFA levels using GWIS in UK Biobank data, finding significant loci around FADS and GRP12.

Omega-3 fatty acid normalizes postsynaptic density proteins via miRNAs regulation in hippocampus and prevents DEHP-induced impairment of learning and memory in mice

This study shows Omega-3 fatty acid mitigates DEHP-induced neurotoxicity in mice by normalizing miRNA expression and preserving synaptic structure and function.

EPA induces an anti-inflammatory transcriptomic landscape in T cells implicating a pathway independent of triglyceride lowering in CVD risk reduction

This study shows EPA induces an anti-inflammatory transcriptomic profile in CD4+ T cells, independent of triglyceride lowering, potentially explaining its cardiovascular benefits.

Maternal n-3 enriched diet reprograms neurovascular transcriptome and blunts inflammation in neonate

This study shows that a maternal n-3 PUFA-enriched diet reprograms the neurovascular transcriptome and reduces inflammation in neonates after LPS-induced infection.

Western diet feeding since adolescence impairs functional hyperemia probed by functional ultrasound imaging at adulthood and middle age: rescue by a balanced ω-3:ω-6 polyunsaturated fatty acids ratio in the diet

This study shows that a Western diet starting in adolescence impairs functional hyperemia in mice, which can be rescued by balancing omega-3 and omega-6 fatty acids in adulthood.

Shared genetic basis informs the roles of polyunsaturated fatty acids in brain disorders

The paper examines the shared genetic basis between polyunsaturated fatty acids and brain disorders using genome-wide association data and identifies causal relationships and shared variants.

Pro-resolving lipid mediators within brain esterified lipid pools are reduced in female rats chronically exposed to traffic-related air pollution or genetically susceptible to Alzheimer's Disease phenotype

This study finds that female rats with Alzheimer's Disease risk genes or exposed to traffic-related air pollution show reduced brain esterified pro-resolving lipid mediators, suggesting sex-specific impacts on inflammation resolution.

Age-linked suppression of lipoxin A4 mediates cognitive deficits in mice and humans

This study shows that reduced lipoxin A4 levels in aging brains contribute to cognitive deficits in mice and humans, suggesting LXA4 as a potential therapeutic target for age-related dementia.

The omega-3-fatty acid docosahexaenoic acid modulates intracellular myo-inositol and its biosynthetic genes.

This study shows that docosahexaenoic acid increases intracellular myo-inositol and its biosynthetic genes, suggesting a potential mechanism for its therapeutic effect in bipolar disorder.

Multi-tissue Multi-omics Nutrigenomics Indicates Context-specific Effects of DHA on Rat Brain

This study shows DHA has different effects on rat brain gene expression, pathways, and metabolic outcomes depending on dietary context.

Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the developing brain

Low maternal omega-3 fatty acid intake impairs microglia-mediated synaptic refinement via the 12-HETE pathway in the developing brain.