Cellular transport and secretion

This study shows that atlastin-1 deficiency in human cortical neurons disrupts ER morphology, endosomal tubulation, and lysosomal proteolysis, linking ER dysfunction to HSP pathogenesis.

This study investigates the roles of ESCRT components in Drosophila blood progenitor maintenance, lineage choice, and immune response, revealing both autonomous and non-autonomous functions.

This study shows that SNX1 and SNX2 regulate MET trafficking, affecting phosphorylation of MET and AKT but not ERK1/2, and influence apoptosis resistance in CRC cells.

The paper optimizes fluorogen-activating proteins (FAPs) for use in S. cerevisiae to enable quantitative endocytic studies and co-localization analysis of proteins.

This study identifies the PI(3,5)P2/ESCRT-III axis as essential for STING degradation via lysosomal microautophagy, preventing sustained type I interferon responses.

This study shows Coxiella burnetii-containing vacuoles interact with host Rab11a and Rab35 for vacuolar expansion, with Rab11a and Rab35 expression patterns changing over infection stages.

The paper identifies that impaired COPII vesicle enlargement due to reduced TANGO1 expression contributes to ER stress in IBD by affecting mucin-2 secretion.

This study shows CD13 activates signaling complexes that promote TNT formation in endothelial cells by regulating PI signaling and actin dynamics.

This study identifies Yet3 as a protein that recruits sterol biosynthesis enzymes to ER contact sites, enabling on-demand sterol production and influencing organellar structure and function.

The paper investigates the presence and dynamic behavior of Golgi satellites in axons, showing they are transported bidirectionally and pause at presynaptic sites regulated by neuronal activity and myosin VI.

This study shows ESCRT-I and ALIX form helical filaments in vivo, serving as structural scaffolds and ESCRT-III assembly templates for membrane scission and viral budding.

The paper shows that SAR1A and SAR1B paralogs have overlapping functions in mice, with SAR1A compensating for SAR1B deficiency.

This study investigates the role of ADAP1 and ARAP1 in CD63 incorporation into multivesicular body intralumenal vesicles and shows their differential regulation of CD63 localization.

This study shows insulin signaling increases Rab4 vesicle transport in axons by recruiting Klp98A via Vps34-PI3Kinase activation in Drosophila.

The paper identifies an amphipathic helix as a targeting motif for ER surface proteins in yeast and humans, showing its conservation and role in membrane localization.

This paper shows that N-terminal tagging of Exo70 disrupts its assembly with the exocyst complex and alters its spatiotemporal behavior at the plasma membrane.

The paper identifies a minimal set of presynaptic proteins that regulate different modes of Ca2+-triggered vesicle fusion and short-term plasticity.

The paper maps the interactome of ARF and ARL proteins using BioID, identifies new localizations, and reveals functional roles of ARL14 in activating PLD1 and cargo trafficking.

The paper challenges the classical cisternal progression model by showing that intra-Golgi transport velocity varies and Golgi residence times differ for different cargos, suggesting a stable compartment model.

The paper explores how liquid-liquid phase separation regulates dense-core vesicle function, specifically the differential release of catecholamines and ATP.

The paper introduces PICT to measure protein distances in living cells, showing exocyst subunit and interacting protein spatial configurations.

This study shows tomosyns inhibit synaptic depression by binding to VAMP2-containing template complexes and preventing SNAP-25 association, rather than competing with VAMP2 for SNARE complex assembly.

This study investigates the role of the C-terminal half of the SNARE domain of Syntaxin-1A in synaptic vesicle stability and neurotransmitter release regulation.

This study shows that otoferlin's free C-terminal end is essential for synaptic vesicle docking and fusion in inner hair cells, as demonstrated by deafness and reduced exocytosis in a knock-in mouse model.

This study shows that SNX4 limits synaptic vesicle docking and release by affecting active zone structure and vesicle density.

This study identifies Sbh1/Sec61β as a specific signal peptide receptor that recognizes and guides substrates into the Sec61 channel through its cytosolic IDR and conserved regions.

This study identifies Exo70's role in herpesvirus secretory vesicle tethering and virion release via the exocyst complex, showing ES2 inhibits herpesvirus infection.

This paper investigates how VP3 protein of birnaviruses targets endosomal membranes via PI3P binding, revealing a two-stage mechanism critical for viral replication.

The paper investigates Drosophila p24 proteins and finds that their interaction with Tango1 is essential for maintaining ER-Golgi interface stability and efficient transport.